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Micromet is Presenting Four Posters on BiTE(R) Antibodies at the International AACR-NCI-EORTC Conference
Date:10/23/2007

Presentation on MCSP-specific BiTE Antibody Selected by AACR for Press

Coverage

BETHESDA, Md., Oct. 23 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company focusing on the development of novel, proprietary antibody-based products for cancer, inflammation and autoimmune diseases, today announced that data on two antibodies developed using BiTE(R) technology will be reported at the joint international meeting of the American Association for Cancer Research (AACR), National Cancer Institute (NCI) and European Organization for Research and Treatment of Cancer (EORTC) being held in San Francisco, CA, from October 22-26. The new findings relate to the mode of action, target biology and therapeutic window for two new BiTE antibodies in pre-clinical development.

BiTE antibodies are T cell recruiting antibodies designed to transiently connect cytotoxic T cells with malignant cancer cells, which has been shown to result in the eradication of cancer cells. The four posters report on the EpCAM (CD326)-specific BiTE antibody MT110, and on a novel BiTE antibody which targets melanoma-associated chondroitin sulfate proteoglycan (MCSP). MT110 is being developed for the treatment of a variety of adeno and squamous cell carcinoma which overexpress EpCAM, while the BiTE antibody which binds to MCSP is being developed for the treatment of metastatic melanoma and other cancers expressing MCSP.

The first poster presentation shows that BiTE antibodies which target the cancer associated antigen MCSP are highly active against melanoma cells by recruiting T cells for efficient tumor cell lysis in vitro (abstract A61). This poster has been selected for inclusi
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SOURCE Micromet, Inc.
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