Navigation Links
Micromet Presents Data at AACR Meeting Showing Elimination of Colorectal Cancer Stem Cells by BiTE Antibody MT110
Date:4/22/2009

DENVER, April 22 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, yesterday presented data at the annual meeting of the American Association for Cancer Research (AACR) in Denver, Colorado, showing that its BiTE(R) antibody MT110 can eliminate cancer stem cells (1). Cancer stem cells are thought to be responsible for resistance of human cancers to chemotherapy and for metastatic relapse. MT110 is in a phase 1 dose-escalating clinical trial in patients with lung or gastrointestinal cancer.

BiTE antibodies such as MT110 represent a novel class of therapeutic antibodies designed to direct the body's cell-destroying T cells against tumor cells. MT110 recognizes cancer cells expressing the epithelial cell adhesion molecule, or EpCAM, a target antigen that is highly and frequently expressed on the surface of many types of solid tumors. EpCAM also has been shown to be expressed on cancer stem cells (2) and to promote tumor formation (3). The data presented at AACR show that the BiTE antibody MT110 can direct T cells to eliminate EpCAM-expressing human colorectal cancer stem cells in cell culture. In addition, data from a study of MT110 in mice showed that the BiTE antibody eliminated even large numbers of implanted cancer stem cells, resulting in a complete inhibition of tumor growth and survival, while untreated animals with implanted cancer stem cells experienced tumor formation and death.

"We are excited to see how potently MT110 can act against highly aggressive colorectal cancer stem cells," commented Patrick Baeuerle, Ph.D., Chief Scientific Officer of Micromet. "Our new findings are encouraging for the ongoing clinical development of MT110."

(1)Muenz, M. et al. Eradic
'/>"/>

SOURCE Micromet, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Micromet to Present at the Future Leaders in the Biotech Industry Conference on April 2, 2009
2. Micromet Adds Sir Walter Bodmer and Bernard Fox to Its Advisory Panel for BiTE Antibody Therapeutics
3. Micromet to Present Six Posters on Progress of BiTE Antibodies at the Annual Meeting of American Association for Cancer Research
4. Micromet, Inc. To Regain Rights to Blinatumomab in North America; Reports Financial Results for the Fourth Quarter and Full Year ended December 31, 2008
5. Micromet to Present at the Cowen Health Care Conference on March 17, 2009
6. Micromet Adds Former Head of Roche Oncology Kapil Dhingra, MD to Board of Directors
7. Micromet to Present at the BIO CEO and Investor Conference on February 10, 2009
8. Micromet Enters Into Agreement for Solid Tumor BiTE Antibody with Bayer Schering Pharma AG
9. Micromet to Present at the RBC Capital Markets Healthcare Conference
10. Micromet Added to NASDAQ Biotechnology Index
11. Micromet, Inc. Reports Third Quarter 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... 26, 2015 ReliantHeart, Inc., an innovative ... a supplier of precision transit-time flow measurement solutions, are ... improve the efficiency of the HeartAssist5® Left ... to experience greater mobility and peace of mind. ... flow board, will draw 1/6th of the power required ...
(Date:3/25/2015)... is one of the most attractive in the emerging ... a growing economy and increasing government investment in healthcare, ... Russian market is set to grow at twice the ... around 10-15% annually reaching an approximate market value of ... Green Cross provides total healthcare solutions that ...
(Date:3/25/2015)... 25, 2015 The surging prevalence ... have fuelled social media growth, with over 50% ... in social networking. Insurance companies are making use ... clients and promote a diversity of their services ... increasingly exploiting social networking services as part of ...
(Date:3/25/2015)... Mass. and REYKJAVIK, Iceland , ... capabilities for using the genome to create better medicine, today ... the largest studies of whole-genome data yet undertaken. ... Nature Genetics – are built around the most ... a team of deCODE scientists led by Kari Stefansson ...
Breaking Biology Technology:LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2
... approval, revolutionary CiTop™ product-line is now available in Israel. Ovalum Ltd., ... clearance to market of its unique CiTop™ product-line in Israel. ... ... Ltd., a privately held Israeli medical device company, has announced today ...
... WuXi PharmaTech (NYSE:,WX), a leading pharmaceutical, biotechnology and medical ... and the United,States, today announced that it was awarded ... its CEO Dr. Ge Li was named one of ... the 8th China,Enterprise Innovation Forum held in Beijing last ...
... 2 Health Systems Implement Diagnosis Decision Support & Knowledge ... ... July 10 Isabel Healthcare, a leading,provider of diagnosis decision ... Midelfort-Mayo Health System, Eau Claire,WI and Children,s Hospitals and Clinics ...
Cached Biology Technology:Ovalum Ltd. Received Clearance to Market the CiTop™ Product-Line in Israel 2WuXi PharmaTech (NYSE: WX) Named the Most Innovative Company in China and CEO Dr. Li the Most Innovative Leader of Chinese Enterprises 2Isabel Healthcare Adds Hospitals in Wisconsin & Minnesota 2
(Date:3/26/2015)... , March 26, 2015 The ... social, recreation and athletic club, today announced it has ... allow freedom of movement for members and staff, while ... a comprehensive process, we selected FST,s IMID Access system ... convenience for our members and staff, in addition to ...
(Date:3/24/2015)... Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) ... Recognition Market 2015-2019" report to their offering. ... to grow at a CAGR of 23.5 percent over ... present scenario and the growth prospects of the Global ... the market size, the report considers the revenue generated ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the ... Business Report" report to their offering. This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... study of its kind, researchers have used tools of paleontology ... chemicals. They have shown that during the evolution of these ... rarer, harder to synthesise forms, giving pointers that will help ... the fossil record has allowed the study of the evolution ...
... of the immune systemcapable of targeting proteins associated with ... biomedical research, the development of diagnostic tests and for ... however, has often been a difficult, costly and laborious ... the Biodesign Institute at Arizona State University have developed ...
... DNA construction, also known as DNA cloning or recombinant DNA ... one of the principal tools of modern biotechnology, used for ... and the development of advanced biofuels. A number of software ... Hillson, a biochemist at the U.S. Department of Energy (DOE),s ...
Cached Biology News:Nature reaches for the high-hanging fruit 2Improved method for capturing proteins holds promise for biomedical research 2Improved method for capturing proteins holds promise for biomedical research 3DNA construction software saves time, resources and money 2DNA construction software saves time, resources and money 3DNA construction software saves time, resources and money 4
... Lyophilized. Lyophilized from 2 mM sodium ... human liver. Cathepsin D is a major ... as a 52 kDa proenzyme. Overexpression of ... associated with higher risk of relapse and ...
Rat Hepatocytes (RH) (>3,000,000 cells)...
... 10X Automation Buffer is a concentrated formulation ... autostainers employing capillary action technology, as well ... in collaboration with David Brigati M.D., Department ... OK. This buffer is recommended for all ...
... users requiring mass detection but not ... TOF Mass spectrometer is ideally suited ... for high performance mass analysis. ... analysis, protein detection, micro-satellite DNA characterization ...
Biology Products: