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Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings
Date:10/23/2007

of EpCAM in cancer stem cell regulation.

"All of these new findings correlate well together and highlight the prospects of EpCAM-directed immunotherapies," commented Carsten Reinhardt, M.D., Chief Medical Officer of Micromet. "While the findings from our collaborators in Munich may finally explain the well-known negative prognostic potential of EpCAM, the clinical data on adecatumumabs potential inhibitory effect on new metastases provide a clear rationale for moving forward into early-stage cancer settings where the goal is prevention of disease re- occurrence rather than palliative shrinkage of large tumor bulk."

All of the above cited abstracts can be viewed on the AACR website at http://www.aacr.org.

About Micromet, Inc. (http://www.micromet-inc.com)

Micromet, Inc. is a biopharmaceutical company focusing on the development of novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases. Three of its antibodies are in clinical development. MT103 (MEDI-538), the first antibody developed using the BiTE(R) technology platform to be clinically validated in Micromet's product pipeline, is being evaluated in a phase 1 clinical trial for the treatment of patients with non- Hodgkin's lymphoma. BiTE antibodies represent a new class of antibodies that activate a patient's own cytotoxic T cells to eliminate cancer cells. Micromet is developing MT103 in collaboration with MedImmune, a subsidiary of AstraZeneca plc. The second clinical stage antibody is adecatumumab (MT201), a human monoclonal antibody targeting EpCAM expressing tumors. Adecatumumab is being developed by Micromet in collaboration with Merck Serono, a division of Merck KGaA in Darmstadt, Germany, in a phase 1b clinical trial evaluating MT201 in combination with docetaxel for the treatment of patients with metastatic breast cancer. The third clinical
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SOURCE Micromet, Inc.
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