Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Diseas...( -- Further analysis of phase 2 br...)

-- Further analysis of phase 2 breast cancer data show preferential activity of adecatumumab on inhibiting the formation of new metastases -- Results from 169 patients treated with adecatumumab demonstrate an

apparent lack of immunogenicity of the antibody

BETHESDA, Md., Oct. 23 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company focusing on the development of novel, proprietary antibody-based products for the treatment of cancer, inflammation and autoimmune diseases, today announced that new data from two previously reported phase 2 studies were presented at the joint international meeting of the American Association for Cancer Research (AACR), National Cancer Institute (NCI) and European Organization for Research and Treatment of Cancer (EORTC) being held in San Francisco, CA, from October 22-26.

Abstract A71 reports on a further analysis of data from the phase 2 trial investigating adecatumumab as single agent in metastatic breast cancer (MBC). Previously, longer time to tumor progression (TTP) has been shown for patients receiving higher doses of adecatumumab and expressing high levels of EpCAM (HR = 0.433 for the comparison of high dose/high EpCAM versus low dose/low EpCAM; p=0.0057). All data have now been re-evaluated in order to investigate the reasons for progression. Whereas no obvious differences were detected for the progression of pre-existing target lesions, a significantly lower incidence of new metastases was observed in patients with very high EpCAM expression (only 3 out of 18 patients with new lesions at week 6; 16.7%) as compared to those with low EpCAM (14 out of 29 patients; 48.3%; p= 0.034). A dose-dependency of this effect was
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