Navigation Links
Micro rheometer is latest Lab On a Chip device
Date:9/1/2010

Researchers at the National Institute of Standards and Technology (NIST) have demonstrated a microminiaturized device that can make complex viscosity measurementscritical data for a wide variety of fields dealing with things that have to flowon sample sizes as small as a few nanoliters. Currently a table-top prototype, the NIST rheometer could be a particularly valuable tool for biotechnologists studying minute quantities of complex materials that must function in confined spaces.

Viscosity, elasticity and how materials flow when subject to a force is the subject of rheology, and the measurements tell a lot about a complicated material like a gel. Is it more like a liquid or a solid? By how much and under what conditions? The popular toy Silly Putty is a classic example of complex viscoelasticity, bouncing better than a rubber ball under a sharp, sudden force but slumping into a puddle when left alone.

One common way to make dynamic rheology measurements (how behavior changes with the speed or frequency of the applied force) is with a sizeable lab instrument that traps a test sample between a fixed plate and one that moves, and measures how much the thin layer of test material resists being deformed. Typical sample sizes are around a couple of milliliters, which doesn't sound like much, but, says polymer scientist Gordon Christopher, for some researchers it's a whole bunch.

"A lot of people in the biosciences are making very complex designer fluids based on proteins where you might make only 10 milliliters at a time. Polypeptide hydrogels for drug delivery or tissue replacement, for example," Christopher explains. "Their flow behaviors are very complicated and you really need to understand them, but in a traditional rheometer your sample for a single test is a large percentage of what you just spent two months making."

Inspired by a talk by a NIST scientist working on the design of novel nano positioning microelectromechanical systems (MEMS), team leader Kalman Migler and his colleagues began a collaboration to build a MEMS device that duplicated a classic sliding-plate dynamic rheometerbut in a space about one-twentieth the size of a postage stamp. The sample size of the MEMS rheometer is about 5 nanoliters. "With our device, if you gave me a milliliter of sample, I could give you back hundreds of tests," Christopher says.

Equally as important, he says, the MEMS rheometer inherently tests materials when they are confined in a very small space. For many biological applications where the material is meant to be used in a confined region like a blood vessel or the interior of a cellor must be injected through a thin needleunderstanding the flow characteristics of small amounts in a small space is more important than knowing how it behaves in bulk.

NIST's early prototype MEMS rheometers include only the core sliding plate mechanism on the MEMS chip, and rely on a microscope and high-speed cameras for the actual measurements. In a more polished version, according to the research team, the necessary sensors could be included on the chip and the entire instrument reduced to a handheld device for, e.g., quality control measurements on a plant floor. The NIST MEMS dynamic rheometer is described in a new paper in Lab on a Chip.*


'/>"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related biology technology :

1. Microplasmin Meets Primary Endpoint in Second Phase III Trial in VMA, Confirms Positive Findings of First Trial
2. MO BIO Laboratories, Inc. DNA Isolation Products Used to Analyze Microbes Present in Deepwater Horizon Oil Plume
3. Frost & Sullivan Recognizes Algasol Renewables for its Micro Algae Biomass Production System
4. Phase III Randomised Controlled Trial Confirms Clinical Efficacy and Safety of Radioembolisation Using 90Y-resin Microspheres for Patients With Inoperable Colorectal Cancer Liver Metastases That Have Failed Chemotherapy
5. Applied Precision Installs New DeltaVision
6. OMX® Super-Resolution Imaging System in the Light Microscopy Imaging Center at Indiana University
7. Livermores DTEM earns innovation award from Microscopy Today
8. Microbix Signs $2 Million Partnership Agreement For its Livestock Semen Sexing Technology (LumiSort(TM))
9. European cooperation ensures global leadership in microelectronics
10. Small wires make big connections for microelectronics
11. Ocean Nutrition Canada Announces Acquisition of Exclusive License to GAT Food Essentials, Omega-3 Microencapsulation-Emulsion Technology
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Micro rheometer is latest Lab On a Chip device
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining centers ... The result of a collaboration among several companies with expertise in toolholding, cutting ...
Breaking Biology Technology:
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems ... seamlessly log work hours, for employers to make sure the right employees are actually ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... project, for the , Supply and Delivery of ... Infrastructure , to Decatur , ... Management Solutions. Numerous renowned international vendors participated in the tendering ... selected for the most compliant and innovative solution. The contract ...
(Date:5/24/2016)... -- Ampronix facilitates superior patient care by providing unparalleled technology to leaders of the ... latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Display- Ampronix News ...
Breaking Biology News(10 mins):