Navigation Links
Michael J. Fox Foundation Offers High-Quality LRRK2 Antibodies for PD Therapeutic Development

-- Part of larger effort to develop and distribute high-quality experimental tools that will speed progress toward better treatments for PD --

NEW YORK, March 23 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation announced that monoclonal LRRK2 antibodies, for use in understanding LRRK2 function and developing LRRK2-based therapeutics, will be available to Parkinson's researchers in academic/nonprofit and industry labs. In mid-April, the antibodies will be available free of charge to the entire PD research community for experimental use. This will allow researchers to undertake large-scale testing of the antibodies and provide feedback on their performance directly to MJFF. Once the best-performing antibodies have been identified, the Foundation will determine a practical distribution mechanism to make them available to the research community going forward.

"Our mission is to accelerate next-generation Parkinson's therapies on their path toward the clinic, and it is impossible to overstate access to high-quality, reliable experimental tools as a critical element of this push," said Katie Hood, CEO. "One of our top priorities is to mobilize financial and intellectual leadership around the creation of research tools and get them into scientists' hands to keep promising therapeutic strategies moving forward full-speed ahead."

The Foundation's ongoing investment in critical research tools is made possible through the generous support of The Brin Wojcicki Foundation.

About LRRK2 and LRRK2 Antibodies

LRRK2 is a Parkinson's-implicated gene discovered in 2004 that is now believed to be the single greatest genetic contributor to the disease. While it is the focus of intensive research in the Parkinson's field, a major roadblock to the successful development of LRRK2-based therapies is the lack of high-quality LRRK2 antibodies. Antibodies are used by researchers to identify where proteins can be found in the body, how they behave in cells, and how to manipulate their activity. Despite numerous attempts by individual researchers, high-quality LRRK2 antibodies are rare and often difficult for labs to obtain.

In 2009 MJFF convened a LRRK2 Antibodies Working Group composed of academic and industry researchers with specific expertise in LRRK2. At the recommendation of this group, MJFF engaged a company specializing in antibody development, Epitomics, Inc., to generate several highly sensitive and specific LRRK2 antibodies in large amounts.

The LRRK2 antibodies project is part of MJFF's broadly integrated strategy to drive LRRK2 research at every stage of drug development and accelerate the path of LRRK2-based drugs to the clinic.

How to Obtain Antibodies

For detailed scientific information on the LRRK2 antibodies and information on how to obtain them, researchers should visit PD Online Research ( or the new Research Tools page located on the Foundation's Web site (

Next Focus Area under MJFF's Research Tools Effort: Pre-clinical Models

In addition to the antibodies announced today, the Foundation is working to develop and create distribution channels for new pre-clinical models of Parkinson's that better mimic the human condition. Multiple strains of new models are expected to come online for distribution over the course of 2010. There is an urgent need for such models, particularly for the development of treatments that could slow or stop the progression of PD (something no current treatment has been conclusively proven to do). The Michael J. Fox Foundation has been a field leader in the development of PD models for several years, with investments totaling approximately $13 million to date.

About The Michael J. Fox Foundation

The Michael J. Fox Foundation is dedicated to ensuring the development of better treatments, and ultimately a cure, for Parkinson's disease through an aggressively funded research agenda. MJFF has funded over $175 million in research to date. 

SOURCE Michael J. Fox Foundation

Back to top



SOURCE Michael J. Fox Foundation
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Delcath Systems Names Michael D. Dellario as Vice President, Global Marketing
2. Michael Langley, DVM, MBA, RAC Joins the Anson Group as a Regulatory Consultant
3. Oxford BioTherapeutics Appoints Michael Moore as Chairman
4. The Michael J. Fox Foundation Announces $1.5 Million in Funding to Advance Development of Drug Targets for Disease-Modifying Parkinsons Disease Treatments
5. Double Helix Consulting Enhances its Strategic Product Commercialization Services with Appointment of Michael Rizzo as Vice President
6. Dr. Michael Merzenich Joins Venerable Short List Honored for Cutting-Edge Neuroscientific Research
7. Clinical Therapeutics Announces the Addition of Michael G. Spigarelli, MD, PhD, as Editor for a Refocused Pediatric, Adolescent, & Maternal Therapeutics Section
8. BioStorage Technologies, Inc., Welcomes Catherine Michael as Global Head of Sample Management Operations
9. Ceregene Receives Additional Grant From Michael J. Fox Foundation to Expand Long-Term Testing of CERE-120 Patients
10. Covance Appoints Dr. Steven M. Michael as Vice President and Chief Scientific Officer of Global Bioanalytical Services
11. Statement From Michael Hansen, CEO of Elseviers Health Sciences Division, Regarding Australia Based Sponsored Journal Practices Between 2000 and 2005
Post Your Comments:
(Date:12/1/2015)... Texas (PRWEB) , ... December ... ... , a leading relationship marketing company specializing in scientifically backed, age-defying products, ... January 2016 issue, which highlights the exponential success and unrivaled opportunities that ...
(Date:12/1/2015)... DIEGO , December 1, 2015 Dr. Harry Lander ... serving as Chief Science Officer and recruits ... Dr. Harry Lander , President of Regen, expands his role to ... and recruits five distinguished scientists to join ... Regen, expands his role to include serving ...
(Date:12/1/2015)... ) has ... Virology and Bacteriology Testing Market: Sales and ... Shares by Test, Innovative Technologies, Competitive Strategies, ... --> ) has announced the ... Bacteriology Testing Market: Sales and Volume Segment ...
(Date:11/30/2015)... MIAMI (PRWEB) , ... November 30, 2015 , ... ... opening of a new, Good Manufacturing Practice (GMP) 10000 in the Santiago Marriott. ... technologies available, and is operated by a world-class team of qualified medical researchers ...
Breaking Biology Technology:
(Date:11/11/2015)...   MedNet Solutions , an innovative SaaS-based eClinical technology ... pleased to announce that it will be a Sponsor of ... to be held November 17-19 in Hamburg ... of iMedNet , MedNet,s easy-to-use, proven and ... has been able to deliver time and cost savings of ...
(Date:11/4/2015)... 2015 --> ... by Transparency Market Research "Home Security Solutions Market - Global ... - 2022", the global home security solutions market is expected to ... The market is estimated to expand at a CAGR ... 2022. Rising security needs among customers at homes, the ...
(Date:10/29/2015)... 2015  Rubicon Genomics, Inc., today announced an ... its DNA library preparation products, including the ThruPLEX ... Plasma-seq kit. ThruPLEX Plasma-seq has been optimized for ... libraries for liquid biopsies--the analysis of cell-free circulating ... in cancer and other conditions. Eurofins Scientific is ...
Breaking Biology News(10 mins):