Navigation Links
Mice teeth explain the troubles with human wisdom teeth
Date:9/26/2007

During evolution, many of a species properties are shaped by ecological interactions. This is readily evident in mammalian teeth, whose many features closely reflect what each species eats. However, for a long time scientists have suspected that genetic and developmental interactions may also influence species-specific properties. Now, researchers at the University of Helsinkis Institute of Biotechnology show how development affects the evolution of teeth, and have devised a simple developmental model to predict aspects of teeth across many species. The results were published in Nature.

In the study in the field of evolutionary developmental biology, the researchers Kathryn Kavanagh, Jukka Jernvall and Alistair Evans in the Institute of Biotechnology of the University of Helsinki first studied cheek tooth, or molar, development in mice. Similarly to human teeth, mouse molars develop from front-to-back so that the first molar appears first and the posterior molars bud sequentially along the jaw. Normally the last molar to develop is the third, or wisdom tooth. Experiments on cultured mouse molars revealed that the size and number of posterior molars depend on previously initiated molars. The mechanism, called an inhibitory cascade, acts much like a ratchet that cumulatively increases size differences of teeth along the jaw. By quantifying their experiments, the researchers constructed a simple mathematical model which they then used to predict relative size and number of molars across many other mouse and rat species. They show that the model accurately predicts tooth proportions and numbers, one curious effect being that the second molar makes up one-third of total molar area, irrespective of species-specific molar proportions.

This new research demonstrates that with advances in the study of the molecular regulation of development, it is now possible to identify how development influences evolution. And this may help explain the troublesome wisdom teeth of modern humans - the blame may lie within a weak inhibitory cascade that allows the development of the last molar in a jaw that is too small.


'/>"/>

Contact: Jukka Jernvall
jernvall@fastmail.fm
358-407-403-478
University of Helsinki
Source:Eurekalert

Related biology technology :

1. Research explains why women lack equal access to angel capital
2. Study explains unexpected conductivity of nanoscale silicon
3. Advertising ambassador explains the reinvention of marketing
4. UW computer scientists tout achievements and explain industry shortcomings
5. Human Primary Preadipocytes and Differentiated Adipocytes
6. Low Abundance cDNA Cloned Using Stratagenes Human Universal cDNA Library
7. Control RT-PCR Primers for Human Gene Transcripts with Varying Abundance
8. New Mammalian Expression Vectors Employ Stable, High-Level Fluorescence Humanized Renilla GFP Reporter
9. Human Universal cDNA Library Array I
10. Map and Link Human Genetic Disorders with SSLP Analysis
11. RT-PCR Primer Sets for Human and Mouse Mismatch Repair Genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2017)... ... September 20, 2017 , ... The award-winning ... Services (Koch) to feature new innovations aimed at helping farmers solve the problem ... American Farmer airs Tuesdays at 8:30aET on RFD-TV. Check your local listings for ...
(Date:9/20/2017)... Blue Bell, PA and College Station, TX (PRWEB) , ... ... ... IPS-Integrated Project Services, LLC (IPS), a leading global provider ... G-CON Manufacturing, Inc. the leading provider of prefabricated cleanrooms, today announced the ...
(Date:9/20/2017)... Dallas-Fort Worth, Texas (PRWEB) , ... September 20, 2017 , ... ... people, stem cell therapy succeeded after standard medicine failed. Many of these people had ... - Progress, Not Regression Free Download (pdf) , “Neil ...
(Date:9/19/2017)... ... September 19, 2017 , ... The ... most dangerous step of sample prep for metals digestion—the addition of acids and ... an affordable price. The system is ideal for any laboratory performing their own ...
Breaking Biology Technology:
(Date:3/23/2017)... -- The report "Gesture Recognition and Touchless Sensing Market by Technology ... Forecast to 2022", published by MarketsandMarkets, the market is expected to be worth ... and 2022. Continue Reading ... ... ...
(Date:3/22/2017)... Lithuania , March 21, 2017   ... and object recognition technologies, today announced the release ... kit (SDK), which provides improved facial recognition using ... cameras on a single computer. The new version ... to improve accuracy, and it utilizes a Graphing ...
(Date:3/22/2017)... , March 21, 2017 Vigilant ... company serving law enforcement agencies, announced today the appointment ... as director of public safety business development. ... law enforcement experience, including a focus on the aviation ... his most recent position, Mr. Sheridan served as the ...
Breaking Biology News(10 mins):