Navigation Links
Mice teeth explain the troubles with human wisdom teeth
Date:9/26/2007

During evolution, many of a species properties are shaped by ecological interactions. This is readily evident in mammalian teeth, whose many features closely reflect what each species eats. However, for a long time scientists have suspected that genetic and developmental interactions may also influence species-specific properties. Now, researchers at the University of Helsinkis Institute of Biotechnology show how development affects the evolution of teeth, and have devised a simple developmental model to predict aspects of teeth across many species. The results were published in Nature.

In the study in the field of evolutionary developmental biology, the researchers Kathryn Kavanagh, Jukka Jernvall and Alistair Evans in the Institute of Biotechnology of the University of Helsinki first studied cheek tooth, or molar, development in mice. Similarly to human teeth, mouse molars develop from front-to-back so that the first molar appears first and the posterior molars bud sequentially along the jaw. Normally the last molar to develop is the third, or wisdom tooth. Experiments on cultured mouse molars revealed that the size and number of posterior molars depend on previously initiated molars. The mechanism, called an inhibitory cascade, acts much like a ratchet that cumulatively increases size differences of teeth along the jaw. By quantifying their experiments, the researchers constructed a simple mathematical model which they then used to predict relative size and number of molars across many other mouse and rat species. They show that the model accurately predicts tooth proportions and numbers, one curious effect being that the second molar makes up one-third of total molar area, irrespective of species-specific molar proportions.

This new research demonstrates that with advances in the study of the molecular regulation of development, it is now possible to identify how development influences evolution. And this may help explain the troublesome wisdom teeth of modern humans - the blame may lie within a weak inhibitory cascade that allows the development of the last molar in a jaw that is too small.


'/>"/>

Contact: Jukka Jernvall
jernvall@fastmail.fm
358-407-403-478
University of Helsinki
Source:Eurekalert

Related biology technology :

1. Research explains why women lack equal access to angel capital
2. Study explains unexpected conductivity of nanoscale silicon
3. Advertising ambassador explains the reinvention of marketing
4. UW computer scientists tout achievements and explain industry shortcomings
5. Human Primary Preadipocytes and Differentiated Adipocytes
6. Low Abundance cDNA Cloned Using Stratagenes Human Universal cDNA Library
7. Control RT-PCR Primers for Human Gene Transcripts with Varying Abundance
8. New Mammalian Expression Vectors Employ Stable, High-Level Fluorescence Humanized Renilla GFP Reporter
9. Human Universal cDNA Library Array I
10. Map and Link Human Genetic Disorders with SSLP Analysis
11. RT-PCR Primer Sets for Human and Mouse Mismatch Repair Genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... , Dec 2, 2016 Research ... report "Nanobiotechnology Applications, Markets and Companies" to their ... , , ... nanobiotechnology by the pharmaceutical and biotechnology industries is anticipated. Nanotechnology ... from formulations for optimal delivery to diagnostic applications in clinical ...
(Date:12/2/2016)... ... , ... The Conference Forum has announced that the 3rd annual Immuno-Oncology ... February 1-3, 2017 at the Roosevelt Hotel in New York City. Led by advisors ... 360-degree approach, which addresses the most up-to-date information regarding business aspects, clinical advancements and ...
(Date:12/2/2016)... , Dec. 1, 2016   SurePure, Inc. ... announced today that the Company has concluded an agreement ... right for a 90-day period to acquire units of ... of approximately USD 3.7 million.  Concurrently ... with Tamarack under which Tamarack will seek regulatory approvals ...
(Date:11/30/2016)... ALBANY, New York , November 30, 2016 /PRNewswire/ ... exceptionally consolidated as a few players hold a dominant ... Lonza Group, Charles River Laboratories International, Inc., and Merck ... global market in 2015. Transparency Market Research observes that ... they are focused on development products that are do ...
Breaking Biology Technology:
(Date:6/20/2016)... Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring announced that after ... secured the final acceptance by all three (3) ... Systems (MAS) installed. Furthermore, Securus will have contracts ... by October, 2016. MAS distinguishes between legitimate wireless ...
(Date:6/9/2016)... Finland , June 9, 2016 ... National Police deploy Teleste,s video security solution to ensure the ... France during the major tournament ... data communications systems and services, announced today that its video ... Prefecture to back up public safety across the ...
(Date:6/2/2016)... , June 2, 2016   The Weather Company , ... Watson Ads, an industry-first capability in which consumers will be ... able to ask questions via voice or text and receive ... Marketers have long sought an advertising ... that can be personal, relevant and valuable; and can scale ...
Breaking Biology News(10 mins):