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Method to deliver molecules within embryonic stem cells improves differentiation
Date:4/9/2008

side of the embryoid body from biodegradable microspheres, you can effectively change the course and synchrony of differentiation, said McDevitt.

To examine the cells in more detail, McDevitt teamed with Georgia Tech School of Biology chair John McDonald and research scientist Nathan Bowen to conduct microarray gene expression studies to determine cell phenotype.

The results revealed enhanced expression of fibroblast growth factor 5 (FGF-5) a marker for primitive ectoderm in the embryoid bodies mixed with retinoic acid-loaded microspheres compared to the other treatment groups after 10 days. The researchers also confirmed increased or inhibited expression of many additional markers.

The importance of these findings is that weve shown that biomaterial-based approaches to regulate stem cell microenvironments can significantly improve differentiation methods, said McDevitt. Our ultimate goal is to improve the efficiency of this differentiation process into specific cell types for cell replacement therapies.


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Contact: Abby Vogel
avogel@gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

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Method to deliver molecules within embryonic stem cells improves differentiation
Method to deliver molecules within embryonic stem cells improves differentiation
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