Navigation Links
Metabolic Solutions Development Company announces publication of data describing a new drug target for diabetes
Date:5/15/2013

ex in the regulation of metabolic function to develop several classes of novel insulin sensitizers, which do not have the side effects that have prevented the development of new therapeutic treatments for type 2 diabetes.

Phase 2 Clinical Results Support New Target Hypothesis
Phase 2b clinical data published in the January 18, 2013 issue of Clinical Pharmacology & Therapeutics on the company's prototype compound, MSDC-0160, a novel once-a-day oral insulin sensitizer and the first in a new class of therapeutic agents called mTOT Modulators, showed this new generation of insulin sensitizer met the study's primary endpoint of significantly reducing fasting plasma glucose (FPG) and significantly reduced hemoglobin A1c (HbA1c). The study was a 90-day, randomized, double-blind, comparator- and placebo-controlled, multi-dose study completed in 258 patients with type 2 diabetes. The study compared three doses of MSDC-0160 (50 mg, 100 mg and 150 mg) to maximum dose Actos (pioglitazone 45 mg) or placebo taken orally once daily for 12 weeks. All treatments were well tolerated. There were no serious adverse events attributed by investigators to the MSDC drug.

About Metabolic Solutions Development Company
Metabolic Solutions Development Company (www.msdrx.com) is a drug discovery and development company investigating novel molecular targets and developing new therapeutics to treat metabolic diseases associated with age-related mitochondrial dysfunction, especially type 2 diabetes.

1 Bricker, et al. (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 337, 96-100; and Herzig, et al. (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science 337, 93-96.

2 Colca,
'/>"/>

SOURCE Metabolic Solutions Development Company, LLC
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Metabolic Pathways Collection at SRI International the Largest in the World
2. Cardiometabolic Health Congress Expert Faculty Evaluate the Clinical Implications of Newly FDA-Approved Treatment for Homozygous Familial Hypercholesterolemia
3. Highly efficient production of advanced biofuel by metabolically engineered microorganism
4. Metabolic engineer synthesizes key breast milk ingredient, makes research possible
5. Profil Institute Continues to Publish New Findings in Metabolic Research
6. MiMedx Group, Inc. to Present at the 6th Annual Canaccord Genuity Cardiovascular, Aesthetics and Metabolic Disorders Conference
7. GenoVive, a pioneer in DNA-based weight management solutions, today announced the companys first European partnership as of May 1, 2013 with DNADIETA based in Poland.
8. Integrated Service Solutions, Inc. Celebrates 15 Years in Business
9. BioLife Solutions Announces Record Revenue of $2.2 Million in First Quarter of 2013
10. Elissa Guerra Joins Pursuit as VP of Client Solutions
11. Challenges and Solutions in Conducting Biosimilar Trials, New Life Science Webinar Hosted by Xtalks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... executives from clinical trial marketing firm BBK Worldwide will lead ... Clinical Trials 2014 , to be held at the Hyatt ... Patient recruitment experts Bonnie A. Brescia , Matthew ... on the benefits of employing an effective patient engagement strategy, ... mobile apps – can be used to drive study participation ...
(Date:8/28/2014)... TALLAHASSEE, Fla. Exciting new work by a Florida ... molecular system that can take your temperature, emit white ... , And, the molecule looks like a butterfly. , ... and Biomedical Engineering in the FAMU-FSU College of Engineering, ... ago, but has continued to discover that his creation ...
(Date:8/28/2014)... August 28, 2014 PrimeSource Building ... materials, selected SoundConnect to support their ... based audio and web conferencing platform GlobalMeet powered ... PrimeSource’s employees’ needs. SoundConnect delivers award winning ... PrimeSource Building Products will be utilizing GlobalMeet ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has raised an ... Otter Capital as a significant new partner. Otter Capital’s ... Agriplier™ technology, building on recent compelling field trial results ... meeting, we have been impressed with Otter Capital’s knowledge ... Sobba, President and CEO of GGI. “We look forward ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... England, March 2 Epistem Plc,(LSE:EHP) the UK ... have signed a research and development collaboration with ... a variety of disease,areas. , ... and drug,discovery programme, with Novartis,s insights into disease ...
... Industry leaders, experts and foreign ministry delegations set to be involved ... ... Singapore (PRWEB) March 2, 2009 -- Asia-Pacific,s largest and ... Security Asia 2009 (GSA 2009), will be held in Singapore from ...
... European, Russian and other International buyers buy luxury ... in Miami Beach, Florida, with new services of ... Christian N. Folland, Esq. Many luxury homes and ... recently, offering huge discounts to cash buyers. Folland,s ...
Cached Biology Technology:Epistem Announces Research and Development Collaboration With a Major Pharmaceutical Company 2News Release: Homeland Security to Take Centre Stage with Global Security Asia 2009 2News Release: Homeland Security to Take Centre Stage with Global Security Asia 2009 3Miami Beach Real Estate Attorney Announces Services to Assist Chinese and other International Real Estate Investors Purchase Discount Florida Homes 2Miami Beach Real Estate Attorney Announces Services to Assist Chinese and other International Real Estate Investors Purchase Discount Florida Homes 3
(Date:8/28/2014)... A Mayo Clinic researcher and his collaborators have developed ... enhance the process of re-engineering cells for biomedical investigation. ... biology methods to aid stem cell engineering. Details of ... described in two back-to-back papers in the journal ... range of uses for all types of cell-based investigations ...
(Date:8/28/2014)... the developmental on-off switch for Streptomyces , a ... of the world,s naturally derived antibiotic medicines. , ... is possible to manipulate this switch to make nature,s ... August 28 in Cell , found that a ... a larger protein called BldD ultimately controls whether a ...
(Date:8/28/2014)... are good examples of complex systems. Their infrastructure ... water for cooling, transport to supply fuel, and ... in the network chain is interconnected with a ... A team of UK-based scientists has studied various ... findings have been published in EPJ B by ...
Breaking Biology News(10 mins):New tool aids stem cell engineering for medical research 2Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3Inter-dependent networks stress test 2
... MCLEAN, Va., Nov. 29, 2012  Northrop Grumman Corporation (NYSE: ... proof of concept for an automated biometric information system ... will be operated for a trial period to enable ... enabled intelligence and to help determine the requirements for ...
... William Cooke, a professor in the UTSA College of Education ... selected to serve as the speaker of the Texas Chapter ... Tour. Over the course of a week, Cooke will deliver ... of ACSM,s Texas Chapter. "This is a big honor ...
... For the first time in its history, the American Society ... opening session of the ASCB,s Annual Meeting, for "An Evening ... Francisco, on Saturday, Dec. 15. Members of the ... will receive complimentary registration to the ASCB keynote addresses ...
Cached Biology News:Northrop Grumman Delivers Australian Automated Biometric Information System Trial Proof of Concept 2UTSA physiologist William Cooke named 2013 Lecture Series Speaker by Texas Sports Medicine Chapter 2Public invited to 'An Evening of Science & Art' at ASCB Annual Meeting 2
... Bio luciferase assay. Mo Bio Laboratories offers the ... you to certify your products ATP-Free with a ... deliver them to your customers in a timely ... 3.5 x 10-12 /l, which will allow you ...
... Sciences provides a comprehensive microarray service ... RNA embedded within non-coding RNAs (ncRNAs) ... proprietary probe design, which enables highly ... small RNAs (1). This comprehensive service ...
Best pricing for 100mg-1.0g scales. Phosphopeptides are our specialty....
... of all human, mouse, and rat ... Genomewide, predesigned siRNAs for a direct ... Ready-to-use, convenient matching solutions for SYBR ... Cost-effective RNAi and downstream analysis ...
Biology Products: