Navigation Links
Metabolic Solutions Development Company Receives $773,000 From the Alzheimer's Drug Discovery Foundation to Fund Phase 2a Trial
Date:7/6/2011

KALAMAZOO, Mich., July 6, 2011 /PRNewswire/ -- Metabolic Solutions Development Company (MSDC), a drug discovery and development company exploiting novel molecular targets to treat metabolic diseases, announced today that it has received a $773,000 grant from the Alzheimer's Drug Discovery Foundation (ADDF) to conduct a pilot Phase 2a trial of MSDC-0160, MSDC's pioneer compound for the treatment of metabolic diseases associated with altered mitochondrial function.

"This funding from ADDF enables us to take an important step in the search for a new treatment for Alzheimer's disease," said Jerry Colca, president and chief scientific officer of MSDC.  "MSDC-0160 is a novel insulin sensitizer that modulates mitochondrial metabolism.  Growing evidence suggests that loss of mitochondrial function and decline in brain glucose metabolism could be a contributing cause of Alzheimer's disease.  This study will help us determine if MSDC-0160 affects glucose utilization in specific regions of the brain and determine the feasibility of conducting future large-scale clinical studies in patients with mild Alzheimer's disease."

The double-blind, placebo-controlled study will involve patients age 55-85 who have been diagnosed with mild Alzheimer's disease.  Up to 50 patients will be randomized to receive either MSDC-0160 (150 mg) or placebo once daily for 90 days.  The effects of MSDC-0160 on brain glucose utilization (measured by FDG-PET) and the safety profile of the compound will be analyzed in addition to global cognitive function.  The study will be performed at Rush University Medical Center in Chicago. The principal investigator is Raj C. Shah, M.D., medical director of the Rush Memory Clinic at the Rush Alzheimer's Disease Center. Analysis of brain glucose utilization will be performed in collaboration with the innovative imaging company Abiant, Inc.

The current funding follows a $100,000 grant from the ADDF in 2009 t
'/>"/>

SOURCE Metabolic Solutions Development Company
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. More Evidence Published That Epidemics of Childhood Obesity, Type 2 Diabetes and Metabolic Syndrome are Linked to Immunization
2. CV Therapeutics Initiates Phase 1 Clinical Trial of CVT-3619, a Novel Potential Treatment for Cardiometabolic Diseases
3. Orexigen(R) Therapeutics Appoints Dennis Kim, M.D., as Senior Vice President, Head of Obesity and Metabolic Disorders
4. Atherotech Unveils New Cardiometabolic Test Panels
5. Poxel SAS Set up to Find Innovative Solutions for Metabolic Diseases Management
6. The University of Amsterdam Joins the MetaMiner Metabolic Diseases Project
7. Bariatric Advantage to Attend American Society of Metabolic and Bariatric Surgery (ASMBS) Conference
8. Distinguished Scientist H. Mario Geysen Joins SRI International to Lead Combinatorial Sciences and Metabolic Diseases Research Programs
9. Max Institute of Minimal Access, Metabolic & Bariatric Surgery Accredited as an International Centre of Excellence for Minimal Invasive Surgery
10. PerkinElmer Expertise and Solutions Integral to Food Safety Monitoring for the Beijing Games : Methods, Applications Expertise and Instrumentation Deployed in Mobile Laboratory
11. StollerUSA Launches Bio-Forge.com to Offer Solutions for Crops Under Stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... (PRWEB) September 02, 2014 PMG ... its 11th clinical research site: PMG Research of Rocky ... and operation of the clinical research department at ... PMG’s presence in eastern North Carolina. This new site ... the patients in Rocky Mount and the surrounding communities, ...
(Date:9/1/2014)... Reportlinker.com announces that a new market ... India Solid Waste Management Vehicles Market Forecast ... In India ... responsible for complete handling and regulation of solid ... 135,000 MT solid waste is generated daily in ...
(Date:8/31/2014)... September 01, 2014 Available spectra ... needs for research and cultivation of a wide ... Valoya’s proprietary LEDs with proven patented and pending ... uncompromised light uniformity in critical applications in contrast ... LEDs. , “Our customers have a large variety ...
(Date:8/29/2014)... Aug. 29, 2014  Pfenex Inc. (NYSE MKT: ... development of high-value and difficult to manufacture proteins ... and reported financial results for the second quarter ... successful completion of our initial public offering, we ... biosimilar product candidates, derived from our proprietary protein ...
Breaking Biology Technology:PMG Research Announces the Formation of its Eleventh Site 2PMG Research Announces the Formation of its Eleventh Site 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8
... ... is excited to announce its latest product offering, PrescriberPRO Mobile. ,PrescriberPRO Mobile ... Solutions’ full database of over 1,000,000 medical prescribers. The application will provide names, ... the United States. , ...
... Lectures ... will be presented at the upcoming ICAD & 3rd ECAA Asia conference. Dr. W. ... Yu will present his latest clinical data showing successful reduction of acne using TriPollar. ... (PRWEB) January 20, 2010 ...
... strengthen host defences could be used to treat inflammatory bowel ... treatment for IBD to date, as explained in a review ... Medical Microbiology . IBD is inflammation of the gastro-intestinal ... pain. It is an emerging disease that affects 20 out ...
Cached Biology Technology:Healthcare Data Solutions Announces New Mobile Application, PrescriberPRO Mobile 2Healthcare Data Solutions Announces New Mobile Application, PrescriberPRO Mobile 3TriPollar Technology Clinically Proven to Significantly Reduce Stretch Marks and Acne 2TriPollar Technology Clinically Proven to Significantly Reduce Stretch Marks and Acne 3Promising probiotic treatment for inflammatory bowel disease 2
(Date:9/2/2014)... everyone has a tipping point. We all want to be ... is great enough. Now, scientists have confirmed the area of ... The result was published online this week in ... even if lying is beneficial," said Lusha Zhu, the study,s ... Tech Carilion Research Institute , where she works with Brooks ...
(Date:9/2/2014)... Bavaria, the Tithonian Konservat-Lagersttte of lithographic limestone is ... of emblematic fossils from that area (for example, ... found fossil insects in the French equivalent of ... species representing the oldest known water treader. , ... Bavarian outcrops, fewer fossils have been obtained from ...
(Date:9/1/2014)... the U.S. diet showed some modest improvement in the ... in the consumption of unhealthy trans fats, but the ... and the poor. , , An unhealthy diet is ... Eating a healthy diet is an important part of ... trends in diet quality is important because it can ...
Breaking Biology News(10 mins):Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 2Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 3Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 4Exceptionally well preserved insect fossils from the Rhône Valley 2Quality of US diet improves, gap widens for quality between rich and poor 2Quality of US diet improves, gap widens for quality between rich and poor 3
... researchers at The Johns Hopkins University School of Medicine reveal ... papers appear in the March issue of The Journal ... opening, many ion channels spontaneously close by inactivation, a process ... channels is important for a variety of biological processes, including ...
... Illinois study touts the benefits of soluble fiberfound in ... the inflammation associated with obesity-related diseases and strengthens the ... immune cellsthey go from being pro-inflammatory, angry cells to ... infection," said Gregory Freund, a professor in the U ...
... NEW ORLEANS, LA. Minerals Management Service (MMS) ... biologists have set sail to learn more about the ... Mexico. The first of the research cruise,s three legs ... is underway. The first and second legs of ...
Cached Biology News:An apple a day? Study shows soluble fiber boosts immune system 2An apple a day? Study shows soluble fiber boosts immune system 3MMS and NOAA scientists study prey of Gulf of Mexico sperm whales 2
... Monoclonal Mouse Antibody to Cytokeratin 5 / ... a high molecular weight, basic type of ... the superficial cell layers of stratified epithelia ... and in mesothelial cells and mesothelioma. Cytokeratin ...
Bovine Coronary Artery Endothelial Cells (BCAEC) (>500,000 cells)...
Bovine Renal Artery Endothelial Cells (BRAEC) (>500,000 cells)...
Bovine Aortic Smooth Muscle Cells (BAOSMC) (>500,000 cells)...
Biology Products: