Navigation Links
Metabolic Solutions Development Company Receives $773,000 From the Alzheimer's Drug Discovery Foundation to Fund Phase 2a Trial
Date:7/6/2011

KALAMAZOO, Mich., July 6, 2011 /PRNewswire/ -- Metabolic Solutions Development Company (MSDC), a drug discovery and development company exploiting novel molecular targets to treat metabolic diseases, announced today that it has received a $773,000 grant from the Alzheimer's Drug Discovery Foundation (ADDF) to conduct a pilot Phase 2a trial of MSDC-0160, MSDC's pioneer compound for the treatment of metabolic diseases associated with altered mitochondrial function.

"This funding from ADDF enables us to take an important step in the search for a new treatment for Alzheimer's disease," said Jerry Colca, president and chief scientific officer of MSDC.  "MSDC-0160 is a novel insulin sensitizer that modulates mitochondrial metabolism.  Growing evidence suggests that loss of mitochondrial function and decline in brain glucose metabolism could be a contributing cause of Alzheimer's disease.  This study will help us determine if MSDC-0160 affects glucose utilization in specific regions of the brain and determine the feasibility of conducting future large-scale clinical studies in patients with mild Alzheimer's disease."

The double-blind, placebo-controlled study will involve patients age 55-85 who have been diagnosed with mild Alzheimer's disease.  Up to 50 patients will be randomized to receive either MSDC-0160 (150 mg) or placebo once daily for 90 days.  The effects of MSDC-0160 on brain glucose utilization (measured by FDG-PET) and the safety profile of the compound will be analyzed in addition to global cognitive function.  The study will be performed at Rush University Medical Center in Chicago. The principal investigator is Raj C. Shah, M.D., medical director of the Rush Memory Clinic at the Rush Alzheimer's Disease Center. Analysis of brain glucose utilization will be performed in collaboration with the innovative imaging company Abiant, Inc.

The current funding follows a $100,000 grant from the ADDF in 2009 t
'/>"/>

SOURCE Metabolic Solutions Development Company
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. More Evidence Published That Epidemics of Childhood Obesity, Type 2 Diabetes and Metabolic Syndrome are Linked to Immunization
2. CV Therapeutics Initiates Phase 1 Clinical Trial of CVT-3619, a Novel Potential Treatment for Cardiometabolic Diseases
3. Orexigen(R) Therapeutics Appoints Dennis Kim, M.D., as Senior Vice President, Head of Obesity and Metabolic Disorders
4. Atherotech Unveils New Cardiometabolic Test Panels
5. Poxel SAS Set up to Find Innovative Solutions for Metabolic Diseases Management
6. The University of Amsterdam Joins the MetaMiner Metabolic Diseases Project
7. Bariatric Advantage to Attend American Society of Metabolic and Bariatric Surgery (ASMBS) Conference
8. Distinguished Scientist H. Mario Geysen Joins SRI International to Lead Combinatorial Sciences and Metabolic Diseases Research Programs
9. Max Institute of Minimal Access, Metabolic & Bariatric Surgery Accredited as an International Centre of Excellence for Minimal Invasive Surgery
10. PerkinElmer Expertise and Solutions Integral to Food Safety Monitoring for the Beijing Games : Methods, Applications Expertise and Instrumentation Deployed in Mobile Laboratory
11. StollerUSA Launches Bio-Forge.com to Offer Solutions for Crops Under Stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... , June 19, 2013  Continuing its long history ... (MI), Beckman Coulter , Inc. announces the U.S. ... new Access AccuTnI+3 troponin I assay for use on ... have depended on Beckman Coulter,s troponin I ... assay has the proven performance to continue providing dependability ...
(Date:6/19/2013)... Today DuPont Executive Vice President James ... in the greatest challenge facing our time – ensuring ... Borel spoke at the International Food and Agribusiness ... need for students to contribute their time and talents ... reached in collaboration with others. , “Food is one ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 BioConvergence ... the speaking faculty at 2013’s BioLogistics Summit in ... conference, coordinated by Cold Chain IQ and IQPC, ... This “complexity” is, in part, attributed to current ... , “Implicit within these trends is an increase ...
(Date:6/19/2013)... (PRWEB) June 18, 2013 A new ... materials, costs and other trends will highlight technical sessions ... California this fall. In its 33rd year, the three-day ... an exhibition of key suppliers, approximately 100 technical presentations ... SPIE, the international society for optics and photonics , ...
Breaking Biology Technology:Beckman Coulter Announces FDA Clearance of New Access AccuTnI+3 Troponin I Assay for the Access 2 Immunoassay System 2Beckman Coulter Announces FDA Clearance of New Access AccuTnI+3 Troponin I Assay for the Access 2 Immunoassay System 3DuPont Leader Calls for New Generation of Food Visionaries to Fight Hunger 2BioConvergence® Presents at BioLogistics Summit on Risk Matrix for Biosamples during Shipment 2‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology 2‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology 3
... 2 GlaxoSmithKline plc (GSK),announced today that Fountain ... a cash tender offer to purchase all,outstanding shares ... SIRT ) (Sirtris), for $22.50 in cash without ... offer is being made pursuant to a,previously announced ...
... P3(TM) Technology Raising the Bar in Motion Preservation, ... Technology,Inc., a leader in innovative medical devices, announced ... cervical total disc,replacement (TDR), NuNec Cervical Arthroplasty Device. ... Zou and Wenwen Wu in Beijing China, on,patients ...
... to $11.7 million, -- Quarterly Net Income Increases ... NEW YORK and HAIKOU, Hainan, China, May ... (OTC Bulletin Board: CPHI),which develops, manufactures, and markets ... its financial results,for the first quarter of 2008., ...
Cached Biology Technology:GlaxoSmithKline Commences Tender Offer to Acquire Sirtris Pharmaceuticals 2GlaxoSmithKline Commences Tender Offer to Acquire Sirtris Pharmaceuticals 3Pioneer(R) Surgical Technology Announces First Human Implants of its NuNec(TM) Cervical Arthroplasty Device 2China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 2China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 3China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 4China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 5China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 6China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 7China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 8China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 9
(Date:6/19/2013)... The Microbial Diversity Course at the Marine Biological ... a Milestones in Microbiology site by the American ... in Microbiology program recognizes institutions and the scientists ... toward advancing the science of microbiology. A ... site is scheduled for Saturday, June 22, 2013, ...
(Date:6/19/2013)... June 19, 2013 AT&T * ... upcoming launch of the ultimate workhorse among ruggedized ... As one of the most ruggedized phones equipped ... Terrain embodies toughened versatility and business-ready features.  Its ... keep workforces moving forward, while also keeping up ...
(Date:6/19/2013)... A new variety of canary seeds bred specifically for ... be ideal for people with celiac disease (CD), scientists ... Journal of Agricultural and Food Chemistry . , ... least 3 million people in the United States alone ... eating wheat, barley, rye and other grains that contain ...
Breaking Biology News(10 mins):Microbial diversity course designated as a 'Milestones in Microbiology' site 2AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 2AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 3AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 4AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 5
... across Europe are embarking on new research to develop a ... million EU citizens and there is no cure," says Dr ... partner in the Food Allergy Specific Therapy (FAST) research project. ... foods to which they are allergic. The threat of severe ...
... Biology are pleased to announce that Dr Audrey ... of this year,s JEB Outstanding Paper Prize. The award ... Journal of Experimental Biology at http://jeb.biologists.org ., ... young scientist to an exceptional research paper. Dussutour was ...
... environmental threat has been detected in North American ... Along with scientists from several Canadian government ... by declining levels of calcium in many temperate, ... Queen,s PhD candidate Adam Jeziorski, lead author of ...
Cached Biology News:Scientists developing food allergy treatment 2French scientist wins the Journal of Experimental Biology Outstanding Paper Prize 2French scientist wins the Journal of Experimental Biology Outstanding Paper Prize 3Queen's University biologists find new environmental threat in North American lakes 2
... Epithelial and endothelial cells-directed ... a RGD peptide-conjugated polyethylenimine which ... integrin-expressing epithelial and endothelial cells. ... in cell-cell and cell-matrix adhesion ...
... WinMelt software is used to ... any DNA sequence up to ... optimizing placement of primers and ... by denaturing gradient gel electrophoresis ...
Request Info...
... Accurate To score SNPs, ... sequencing, the gold standard in DNA analysis. ... The polymorphic locus can be confirmed by ... DNA sequencing also provides sequence context information, ...
Biology Products: