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Metabolic Solutions Development Company Receives $773,000 From the Alzheimer's Drug Discovery Foundation to Fund Phase 2a Trial
Date:7/6/2011

KALAMAZOO, Mich., July 6, 2011 /PRNewswire/ -- Metabolic Solutions Development Company (MSDC), a drug discovery and development company exploiting novel molecular targets to treat metabolic diseases, announced today that it has received a $773,000 grant from the Alzheimer's Drug Discovery Foundation (ADDF) to conduct a pilot Phase 2a trial of MSDC-0160, MSDC's pioneer compound for the treatment of metabolic diseases associated with altered mitochondrial function.

"This funding from ADDF enables us to take an important step in the search for a new treatment for Alzheimer's disease," said Jerry Colca, president and chief scientific officer of MSDC.  "MSDC-0160 is a novel insulin sensitizer that modulates mitochondrial metabolism.  Growing evidence suggests that loss of mitochondrial function and decline in brain glucose metabolism could be a contributing cause of Alzheimer's disease.  This study will help us determine if MSDC-0160 affects glucose utilization in specific regions of the brain and determine the feasibility of conducting future large-scale clinical studies in patients with mild Alzheimer's disease."

The double-blind, placebo-controlled study will involve patients age 55-85 who have been diagnosed with mild Alzheimer's disease.  Up to 50 patients will be randomized to receive either MSDC-0160 (150 mg) or placebo once daily for 90 days.  The effects of MSDC-0160 on brain glucose utilization (measured by FDG-PET) and the safety profile of the compound will be analyzed in addition to global cognitive function.  The study will be performed at Rush University Medical Center in Chicago. The principal investigator is Raj C. Shah, M.D., medical director of the Rush Memory Clinic at the Rush Alzheimer's Disease Center. Analysis of brain glucose utilization will be performed in collaboration with the innovative imaging company Abiant, Inc.

The current funding follows a $100,000 grant from the ADDF in 2009 t
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SOURCE Metabolic Solutions Development Company
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