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Metabolic Solutions Development Company Presents New Brown Fat Research at the European Association for the Study of Diabetes
Date:9/13/2011

ications for developing future therapies and provide a framework for further defining the mTOT biochemical pathway."

Study Methodology and Key Results

In this in vitro study, progenitor cells from axillary adipose depots (fat tissue located in the armpit region) were isolated from mice and placed in tissue culture under defined conditions. Treatment of these cells with micromolar concentrations of the MSDC compounds elicited a time- and dose-dependent differentiation of the progenitor cells into brown-like adipose cells. The brown-like adipose cells express UCP1 message and protein in a process that includes increased mitochondrial biogenesis. These effects were not attenuated by the potent PPARy antagonists, T0070907 and GW9662, confirming the PPAR-independent pharmacology of the MSDC compound.  Importantly, the cells from axillary adipose depots also secreted the insulin-sensitizing hormone adiponectin in response to the MSDC compounds. These results show that novel insulin sensitizers that increase brown fat could have important implications for the development of new therapies to treat type 2 diabetes.

About Metabolic Solutions Development Company

Metabolic Solutions Development Company (www.msdrx.com) is a drug discovery and development company investigating novel molecular targets and new therapies for metabolic diseases associated with mitochondrial dysfunction, especially insulin resistance and type 2 diabetes. The company has raised more than $55 million to support development of its lead compounds MSDC-0160 and MSDC-0602.


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