Navigation Links
Metabolic Solutions Development Company Presents New Brown Fat Research at the European Association for the Study of Diabetes
Date:9/13/2011

LISBON, Portugal, Sept. 13, 2011 /PRNewswire/ -- Metabolic Solutions Development Company, LLC (MSDC) presented results today demonstrating its novel insulin sensitizers, MSDC-0160 and MSDC-0602, stimulate progenitor cells within subcutaneous fat tissue to become brown-like fat cells instead of white fat cells. Brown fat, which diminishes with age, burns calories while white fat stores calories. The mechanism of action by which MSDC-0160 and MSDC-0602 cause these effects is independent of the activation PPARy, a factor that drives the expansion of white fat. These findings suggest the potential for minimizing weight gain normally associated with currently marketed insulin sensitizers, and may result in weight loss in longer duration clinical studies. The data were presented in an oral presentation at the 47th European Association for the Study of Diabetes (EASD) Annual Meeting in Lisbon, Portugal.

MSDC-0160 and MSDC-0602 are novel insulin sensitizers that are selective for mTOT, a mitochondrial molecular target that functions as a "switch" connecting mitochondrial metabolism to important cell functions.  Previous studies have shown the PPAR-independent pharmacology of each of these compounds results in improved insulin action, preservation of beta cell function, and generation of brown fat. The amount of brown fat is inversely proportioned to body weight (and white fat).

"Given the novel mechanism of action of our compounds, we expect to see weight control over longer duration treatments with these new clinical candidates as a result of the "browning" of adipose or fat stores," said Jerry Colca, Ph.D., president and Chief Scientific Officer of MSDC. "These results in the preclinical setting have important mechanistic impl
'/>"/>

SOURCE Metabolic Solutions Development Company, LLC
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Metabolic Solutions Development Company Receives $773,000 From the Alzheimers Drug Discovery Foundation to Fund Phase 2a Trial
2. Max Institute of Minimal Access, Metabolic & Bariatric Surgery Accredited as an International Centre of Excellence for Minimal Invasive Surgery
3. Distinguished Scientist H. Mario Geysen Joins SRI International to Lead Combinatorial Sciences and Metabolic Diseases Research Programs
4. Bariatric Advantage to Attend American Society of Metabolic and Bariatric Surgery (ASMBS) Conference
5. The University of Amsterdam Joins the MetaMiner Metabolic Diseases Project
6. Poxel SAS Set up to Find Innovative Solutions for Metabolic Diseases Management
7. Atherotech Unveils New Cardiometabolic Test Panels
8. Orexigen(R) Therapeutics Appoints Dennis Kim, M.D., as Senior Vice President, Head of Obesity and Metabolic Disorders
9. CV Therapeutics Initiates Phase 1 Clinical Trial of CVT-3619, a Novel Potential Treatment for Cardiometabolic Diseases
10. More Evidence Published That Epidemics of Childhood Obesity, Type 2 Diabetes and Metabolic Syndrome are Linked to Immunization
11. MedNet Solutions Achieves the Inc. 5000 List Five Years in a Row
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... Morton Grove, IL (PRWEB) , ... August 31, ... ... genotoxic impurities (PGIs), as a high priority in the drug development approval process. ... process. , This year, Regis Technologies, Inc., a Chicago-based CMO, has been ...
(Date:8/31/2015)... City, CA (PRWEB) , ... August 31, 2015 , ... ... System. Minerva is the first commercially available new FDA approved system in ... treatment Success rate of 92%, the high Amenorrhea (zero bleeding) rate of 66%, the ...
(Date:8/30/2015)... England , August 31, 2015 ... Wartezeit   einer Frau   für chirurgische   Behandlung ... Alter von 7-90   werden für eine   ... soll 1200 Frauen behandeln und die Anzahl ausgebildeter Chirurgen ... Astellas gab heute bekannt, dass  Action on ...
(Date:8/28/2015)... August 28, 2015 According to ... Sera, Cryogenic Storage Systems, Thawing Equipment, Alarms), by Biospecimen ... Clinical Trials), End User - Global Forecast to 2020", ... to reach USD 3,731.03 Million by 2020 from USD ... 11.65% between 2015 and 2020. Browse ...
Breaking Biology Technology:Regis Shares Expert Advice on Impurities in Drug Development 2Regis Shares Expert Advice on Impurities in Drug Development 3U.S. FDA Approves Minerva Endometrial Ablation System 2U.S. FDA Approves Minerva Endometrial Ablation System 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5
... Inc.,(Nasdaq: RDEA ) announced today that Barry D. Quart, PharmD, ... UBS Global Life Sciences Conference, Date: ... Time Location: Grand Hyatt, New York ... Focus Conference, Date: Tuesday, October 7, 2008 ...
... Serve Growing Highly-Potent and Cytotoxic ... ... Pharmatek -- a,pharmaceutical chemistry development organization supporting the,pharmaceutical industry -- ... in San Diego., The 18,000 sq. ft. facility includes ...
... the use of sensors or barcodes at the nanoscale, North ... tiny organic particles, when heated to the proper temperature, bob ... film and then can reversibly recede below the surface when ... of particles to a surface and then sinking them back ...
Cached Biology Technology:Ardea Biosciences to Present at the UBS Global Life Sciences Conference and the Third Annual JMP Securities Healthcare Focus Conference 2Pharmatek Announces Official Opening of New Highly-Potent & Cytotoxic Development and Manufacturing Facility 2NC State engineers discover nanoparticles can break on through 2
(Date:9/1/2015)... MOUNTAIN VIEW, Calif. , Sept. 1, 2015 ... interaction with travelers during airport passenger screening. This ... which the passenger screening process will become unintrusive. ... and pre-clearance based on voluntary background investigations will ... analysis from Frost & Sullivan, Global Airport ...
(Date:8/31/2015)... 31, 2015 Growing need for ... government digitization projects to drive India ... TechSci Research report, " India Biometrics Market Forecast & Opportunities, ... is projected to grow at a CAGR of over 35% ... on account of extensive use of biometric technology in the ...
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/st5b3m/saudi_arabia ) has announced the ... - Growth, Trends & Forecasts (2014-2020)" report to ... Sensors market is estimated at $0.23 billion by 2018 ... The near future will bring biomedical sensors ... individual. These sensors can be set to trigger alerts ...
Breaking Biology News(10 mins):The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 2The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 3The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 4India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 2India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 3Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2
... 03, 2010, Seoul, S. Korea Institut Pasteur Korea ... the chemical compound collection of Novartis Institute for Tropical ... IP-K,s PhenomicScreen is a high-throughput, high-content visual screening ... Over the past year, PhenomicScreen has been used to ...
... Intense, individually tailored dietary treatment for acutely hospitalized elderly ... new study by researchers at Ben-Gurion University of the ... prestigious Journal of the American Geriatric Society ... percent) of the control group compared to the intervention ...
... Several of the most promising technological research projects at ... infusion of federal cash to help them through the ... the commercial market. With $5.1 million in federal ... System of Maryland research institutions and the U.S. Army ...
Cached Biology News:Personalized diets for elderly after hospitalization decreases mortality rates 2$5.1 million Army-Md. alliance speeds university research to market 2$5.1 million Army-Md. alliance speeds university research to market 3$5.1 million Army-Md. alliance speeds university research to market 4$5.1 million Army-Md. alliance speeds university research to market 5
... Genetic Analysis System, which processes two 96-well plates ... adds a higher level of throughput to the ... of Beckman Coulters new GenomeLab family of products*, ... Biomek series liquid handers, for increased automation. ...
... Library Panels were designed for full-length gene ... PCRs to identify the desired cDNA clone. ... a 96-well "Master Plate," where each well ... identified the positive well(s) by gel electrophoresis ...
... Pathway Studio Enterprise is integrated informatics ... regulatory mechanisms and drug response modeling. ... the worlds largest knowledge base of ... with MedScan module capable of extracting ...
Application: For use as a carrier in nucleic acid purification and precipitation. Physical form: Solution in 10 mM Tris HCl, pH 7.4, 1 mM EDTA Concentration: 9-11 mg/mL Physical Form: buffered aqu...
Biology Products: