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Metabolex Appoints Raymond Urbanski M.D., Ph.D. to Position of Chief Medical Officer
Date:10/20/2011

nal insufficiency, while showing excellent renal safety. In addition to lowering glucose, arhalofenate lowered triglycerides and markers of inflammation. Thus, arhalofenate is a potential best-in-class uric acid lowering agent that not only corrects the hyperuricemia associated with gout, but also addresses other aspects of metabolic syndrome such as insulin resistance and hypertriglyceridemia that are prevalent in this patient population.  

About Hyperuricemia and Gout

Gout is a chronic, progressive rheumatic disease, caused by an inflammatory response to uric acid crystals deposited in joints and soft tissues as a result of excess uric acid in the blood (hyperuricemia). Elevated serum uric acid levels cause urate crystals for form in joints triggering acute arthritic flares, chronic destructive arthropathy and formation of tophi.  According to the NHANES (2007-2008) study, the incidence of hyperuricemia in the US is over 45 million and over 8 million have progressed to a gout diagnosis.  

About Metabolex

Metabolex is a privately-held biopharmaceutical company focused on the discovery and development of proprietary new medicines for the treatment of metabolic diseases. The company has three clinical-stage compounds: arhalofenate, which has completed four Phase 2 trials and is currently conducting three Phase 2b trials for gout; MBX-2982, which has recently completed a Phase 2a trial in patients with Type 2 diabetes; and MBX-8025, which has completed a Phase 2 trial in patients with dyslipidemia.

For additional information about Metabolex and its development pipeline, visit www.metabolex.com.

Contact:
Donald Hill
Metabolex, Inc.
(510) 293-8800
dhill@metabolex.com


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