Navigation Links
Metabolex Announces Positive Results From its Clinical Study of Arhalofenate in Combination With Febuxostat
Date:12/8/2011

HAYWARD, Calif., Dec. 8, 2011 /PRNewswire/ -- Metabolex today announced positive results from its clinical study of arhalofenate in combination with febuxostat (Uloric™, Takeda Pharmaceutical Company Limited). A key goal in the treatment of gout is to address the patient's underlying hyperuricemia by treatment with drugs that lower serum uric acid (sUA). In the US, the goal of treatment is to reduce sUA levels to below 6 mg/dL. However, patients with severe tophaceous gout would benefit from reducing their sUA values below 5 or even 4 mg/dL because this would result in more rapid dissolution of their UA crystal deposits. Most patients treated with currently marketed xanthine oxidase inhibitors (allopurinol or febuxostat) alone do not reach these goals. Arhalofenate, Metabolex's lead product candidate for the treatment of hyperuricemia and gout, is a uricosuric agent that could provide additional sUA lowering when used in combination with xanthine oxidase inhibitors and be a treatment option for patients with tophaceous gout.

Clinical Study of Combination of Arhalofenate and Febuxostat

This study was an open label clinical pharmacology study on a single cohort of 11 gout patients with sUA levels of at least 8 mg/dL (mean of 9.1 mg/dL). The primary goal of the study was to assess the response rate (percentage of patients reaching goal) for the sUA targets of 5 and 4 mg/dL when treated in combination with the highest dose (80 mg) of febuxostat approved in the US and two doses (400 and 600 mg) of arhalofenate. The patients were either treatment naive or had discontinued uric acid lowering therapies for a period prior to entering the study. All patients received colchicine throughout the study for flare prophylaxis. After a two week run-in period for sUA stabilization, all 11 patients received febuxostat (80 mg) for one week. Subsequently, patients were administered 400 mg of arhalofenate for two weeks followed by up-titration of arhalo
'/>"/>

SOURCE Metabolex
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Two Metabolex Projects Recognized in Windhovers Top 10 Lists for Partnering Opportunities
2. Metabolex Announces Positive Results From Phase 1a Clinical Trial of MBX-2982
3. Metabolex Announces Election of Kurt von Emster to Board of Directors
4. Metabolex Initiates Phase 2 Trial of Arhalofenate
5. Metabolex Appoints Raymond Urbanski M.D., Ph.D. to Position of Chief Medical Officer
6. Metabolex Gout Program Recognized in Windhovers Top 10 Most Interesting Projects to Watch
7. China-Biotics, Inc. Announces Conference Call to Discuss First Quarter 2009 Financial Results
8. Odyssey Thera Announces Milestone Achievement in Pfizer Alliance
9. InNexus Biotechnology Announces Launch of Large Scale Primate Study of DXL625
10. Anesiva Announces Second Quarter 2008 Financial Results and Update
11. SGX Pharmaceuticals Announces Financial Results for the Three and Six Months Ended June 30, 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... "Ischemic Stroke and Cerebral Stroke Global ... the Ischemic Stroke and Cerebral Stroke clinical trial ... relating to the clinical trials on Ischemic Stroke ... Stroke Research Report 2014 at: http://www.marketresearchreports.biz/analysis/213207 ... numbers and their recruitment status as per the ...
(Date:7/25/2014)... Trillions of bacteria live in each person,s digestive tract. ... food and stave off harmful infections, but their role ... help shed light on the role of these bacteria, ... Eric Alm recently tracked fluctuations in the bacterial populations ... findings, described in the July 25 issue of the ...
(Date:7/25/2014)... , July 25, 2014 Research ... "Global Metabolomics Market 2014-2018" report to ... Metabolomics or Metabonomics is the ... has become a new experimental technique that is ... environmental sciences. Metabolites are small molecules that are ...
(Date:7/25/2014)... CA (PRWEB) July 25, 2014 WABC Radio ... Your Pet with Lorry Young will be hosting California-based ... talk about stem cell therapy in pets. Dr. Harman ... benefits of stem cell therapy for pets suffering from osteoarthritis ... the Regenerative Veterinary Medicine industry forward. , Young has invited ...
Breaking Biology Technology:Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3
... DIEGO, Dec. 12 Arena Pharmaceuticals,Inc. (Nasdaq: ... and Randall,E. Woods were appointed to its board ... seventh and eighth independent directors and bring,significant financial ... board of directors. Arena,s board also appointed Mr.,Schneider ...
... maintain successful partnerships, patient, recruitment expertise and its ... CINCINNATI, Dec. 12 Kendle (Nasdaq: KNDL ... today,announced it was named "Best CRO" at the ... selected from among leading global CROs by a,distinguished ...
... 12 The Center for Molecular,Medicine (CMM) today announced ... to offer a new test to help guide the ... or "advanced")., The CMM (http://www.cmmdx.org ) is ... physicians as a vital new tool in managing,patients with ...
Cached Biology Technology:Arena Pharmaceuticals Appoints Phillip M. Schneider and Randall E. Woods to Board of Directors 2Arena Pharmaceuticals Appoints Phillip M. Schneider and Randall E. Woods to Board of Directors 3Kendle Named Best CRO for Second Consecutive Year by Leading Global Pharmaceutical Publication Scrip 2Center for Molecular Medicine Among First Labs in Nation to Offer Groundbreaking Test to Aid in Treatment of Colorectal Cancer 2
(Date:7/28/2014)... (July 28, 2014) Rice University researchers are using ... varying flexibility that can be used as microscale models ... that "bead-spring" polymers, introduced as theory in the 1950s, ... required and should be of interest to materials scientists ... work led by Rice chemical and biomolecular engineer Sibani ...
(Date:7/28/2014)... prevent and treat HIV infection has been problematic until ... can arouse as they get rid of the invaders. ... Institute and the National Institutes of Health (NIH) have ... interferons around the time of infection could have ... research appeared in Nature . , Interferons, ...
(Date:7/28/2014)... explorer Roald Amundsen became the first man to reach ... 100 years later, an international team of scientists led ... have proven that air pollution from industrial activities arrived ... collected from widely spaced locations around the Antarctic continent, ... accurate and precise reconstruction to date of lead pollution ...
Breaking Biology News(10 mins):Seeing is bead-lieving 2Interfering with interferon 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 3
... Climate change is causing higher air and water temperatures ... have shrunk the geographic region where blue mussels are able ... researchers published in the Journal of Biogeography . ... live along the East Coast as far south as Cape ...
... Einstein College of Medicine of Yeshiva University has been named ... Centers of Excellence in the Basic Biology of Aging. The ... pursuit of basic research into the biology of aging. Einstein,s ... National Institute on Aging. "Einstein has become a leader ...
... A newly formed advisory committee will develop ... environmental and genetic factors related to breast cancer. ... Coordinating Committee (IBCERCC) was established by the National ... with the National Cancer Institute (NCI), to review ...
Cached Biology News:Too hot to handle: Impacts of climate change on mussels 2Einstein designated an NIH Center of Excellence for aging research 2Einstein designated an NIH Center of Excellence for aging research 3Einstein designated an NIH Center of Excellence for aging research 4New breast cancer committee to establish federal research agenda 2New breast cancer committee to establish federal research agenda 3
Human RELT/TNFRSF19L MAb (Clone 238104)...
...
... assay kit measures NOS activity by monitoring ... This assay is simple, sensitive, and specific ... with both crude and purified enzyme preparations. ... for 50 total reactions. Radiolabeled arginine and ...
Human TSLP MAb (Clone 258136)...
Biology Products: