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Mercury Therapeutics, Inc: Lead Series of Indirect AMPK Activators Licensed to Makoto Life Sciences
Date:3/12/2008

iming two novel lead series of AMPK activators.

MTI is an early stage drug discovery company focusing on the development of small molecule candidates against a number of selected protein kinase drug targets in metabolic diseases and oncology. MTI's main focus is on the discovery and development of orally active small molecule activators of AMPK, a well-validated though largely unexploited, protein kinase drug target in metabolic disease. While a number of anti-diabetic drugs currently on the market, including metformin (Glucophage(R)) and pioglitazone (Actos(R)), act indirectly to activate AMPK, MTI is seeking to develop the first orally available direct AMPK activator. The potential indications of a successful AMPK targeted drug include Type-2 diabetes, hyperlipidemia, obesity, metabolic syndrome and endocrine cancers.

About Makoto Life Sciences, Inc.

Makoto Life Sciences, Inc. is a leading independent company focused on small molecule target identification. The company has developed a technology platform and capabilities specifically optimized to identify the targets of highly potent small molecules. In 2006, the company entered into a major discovery program with Taiho Pharmaceuticals Co., Ltd. of Japan focused on identifying the targets of compounds implicated in cancer and certain inflammatory diseases. The company was founded by academic research scientists associated with Harvard University and is located in Cambridge, MA.


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