Navigation Links
Mercury Therapeutics, Inc: Lead Series of Indirect AMPK Activators Licensed to Makoto Life Sciences
Date:3/12/2008

iming two novel lead series of AMPK activators.

MTI is an early stage drug discovery company focusing on the development of small molecule candidates against a number of selected protein kinase drug targets in metabolic diseases and oncology. MTI's main focus is on the discovery and development of orally active small molecule activators of AMPK, a well-validated though largely unexploited, protein kinase drug target in metabolic disease. While a number of anti-diabetic drugs currently on the market, including metformin (Glucophage(R)) and pioglitazone (Actos(R)), act indirectly to activate AMPK, MTI is seeking to develop the first orally available direct AMPK activator. The potential indications of a successful AMPK targeted drug include Type-2 diabetes, hyperlipidemia, obesity, metabolic syndrome and endocrine cancers.

About Makoto Life Sciences, Inc.

Makoto Life Sciences, Inc. is a leading independent company focused on small molecule target identification. The company has developed a technology platform and capabilities specifically optimized to identify the targets of highly potent small molecules. In 2006, the company entered into a major discovery program with Taiho Pharmaceuticals Co., Ltd. of Japan focused on identifying the targets of compounds implicated in cancer and certain inflammatory diseases. The company was founded by academic research scientists associated with Harvard University and is located in Cambridge, MA.


'/>"/>
SOURCE Mercury Therapeutics Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Cell Therapeutics, Inc. (CTI) to Present at 7th Annual WBBA Invest Northwest Conference
2. Cell Therapeutics, Inc. (CTI) to Report Fourth Quarter and Year-End Financial Results on March 13
3. Cell Therapeutics, Inc. to Hold Conference Call to Update on Recent Transactions and Upcoming Milestones
4. M. Scott Harris, M.D., Joins Ocera Therapeutics, Inc., as Chief Medical Officer
5. Cell Therapeutics, Inc. (CTI) Announces Cancellation of Approximately $9.1 Million of Existing Notes due 2008
6. Mersana Therapeutics, Inc. Appoints Chief Scientific Officer, Timothy B. Lowinger, Ph.D.
7. Cell Therapeutics, Inc. (CTI) Projects Zevalin(R) Sales of $15 Million With Cash Flow Breakeven for Commercial Operations in 2008
8. Cell Therapeutics, Inc. (CTI) to Present at 10th Annual BIO CEO & Investor Conference
9. Nile Therapeutics, Inc. to Present at Upcoming BIO CEO & Investor Conference
10. Velcura Therapeutics, Inc. Teams with International Discovery Sourcing Consultants to Develop New Therapeutic Molecules for Cancer and Bone Disease
11. Sonexa Therapeutics, Inc., Raises $30 Million in Series A Financing to Focus on Alzheimers Treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2008)...ChemDiv Inc. and Avineuro,Pharmaceuticals Inc. ha...ment,collaboration including formulation, safety ...f neurodegenerative and psychiatric disorders. R&a...ity Research Institute, ChemDiv,s research,subsid...or research funding of,clinical candidate compoun...
(Date:11/20/2008)...become the United Kingdom,s lead centre for the de...tacks, after a funding boost from the Engineering ...t 7m from the EPSRC will help fund a new Innovatio...ormation Technologies (CSIT) - which will be based...ns and Information Technology (ECIT) in the Northe...
(Date:11/20/2008)...wswire-FirstCall/ -- Par Pharmaceutical Companies,... District Court for the District of New Jersey las...n for a temporary restraining order (TRO) halting ...esonide inhaled solution). In conjunction with th...nd that it too would halt all sales of its authori...
(Date:11/20/2008)...tCall/ -- Sigma-Aldrich (Nasdaq: SIAL ),announc...QUALITY and iScale,Oligos(TM) siRNA. MISSION(R) I...pected to allow researchers to successfully take t...est purity and quality siRNA required for RNAi res...to be well suited to target,validation and pre-cl...
Breaking Biology Technology:ChemDiv and Avineuro Extend Collaboration on Alzheimer's Disease and Schizophrenia 2Queen's 'secures' £25m for UK's cyber-safety 2Par Pharmaceutical Halts Shipment of Budesonide Inhalation Suspension 2Sigma-Aldrich Introduces MISSION(R) In VIVO QUALITY and iScale Oligos(TM) siRNA, a Superior Quality siRNA Designed for RNAi Research in Animal Models 2
...bout the emergence of some new angel groups in Ill...VCs and funds focused on early stage funding. I ha...rend. , ,There is good reason for this as most of ...comparison to their east and west coast cousins. T...pe of company in the Midwest. , ,In fact, as I hav...
...ion last week to merge its Imaging and Printing Gr...g and Personal Systems Group (IPSG) is a major mil...hnology brand. By combining these two units, HP h...ery room in the digital home. That may be the key ...,The consumer technology market is anyones game to...
...rvard Business School Press) takes a detailed look...rew up playing them. , ,Authors John C. Beck and...surveys to give business managers a lesson on how ...n the workforce whose ways of thinking on competi...ped by video games. , ,The books sensationalist su...
...ee of the top video-game researchers will show off...ience on Thursday at the Fluno Center in Madison. ...Laboratory , WTN and Accelerate Madison are hold... Business and Learning, which will center on the r...d to the workforce. , ,The video game industry has...
Other Biology Technology:Midwest angel investment in life sciences on the rise 2Midwest angel investment in life sciences on the rise 3Midwest angel investment in life sciences on the rise 4Midwest angel investment in life sciences on the rise 5Midwest angel investment in life sciences on the rise 6HP charges toward the living room 2HP charges toward the living room 3Got Game makes big claims; can 90 million people think the same? 2Businesses and educators to preview video games for training 2Businesses and educators to preview video games for training 3
(Date:11/20/2008)...urological Institute at St. Joseph,s Hospital and ...en eye motions and the perception of illusory moti...n Macknik, PhD, director of the Laboratory of Beha..., director of the Laboratory of Visual Neuroscienc... conducted a study based on the Enigma painting, a...
(Date:11/20/2008)...wn soybeans and turned them into many useful produ...ean grows, blooms or produces like it does, resear...versity of Georgia professor Wayne Parrott aims to...grant from the National Science Foundation and a j..."I,m convinced that soybeans would be so much more...
(Date:11/19/2008)...ellers posed by Southern California wildfires like...ed by officials. , Detailed particulate analysis... fires indicates that the composition posed more s...ly realized, according to a new paper analyzing pa...alifornia. , The paper, entitled "Physicochemic...
(Date:11/19/2008)... range northward because of climate change may be ...es than native plants. , So concludes a team of ...icist. The team,s findings, reported in today,s on...nts could become invasive if they spread to places... paper is the first to suggest that the mechanisms...
Breaking Biology News(10 mins):Soybean grant gives researchers tools to unravel better bean 2Where there's wildfire smoke, there's toxicity 2Climate change opens new avenue for spread of invasive plants 2ReBuilder Medical Technologies Inc Says No to OTC Rather Wait for NASDAQ 16417 1ReBuilder Medical Technologies Inc Says No to OTC Rather Wait for NASDAQ 16417 2High Dose Chemo Fails Against Small Cell Lung Cancers 16414 1High Dose Chemo Fails Against Small Cell Lung Cancers 16414 2How fast youll age is written in the bones TAU research finds 16411 1How fast youll age is written in the bones TAU research finds 16411 2Professionals Use Drugs to Sharpen Their Minds Survey Finds 16408 1Professionals Use Drugs to Sharpen Their Minds Survey Finds 16408 2Professionals Use Drugs to Sharpen Their Minds Survey Finds 16408 3
...g other biomolecular researchers, the Department o...as become the first institution outside the United...nsortium of Great Britain. , The BioSimGrid was or... Oxford, Southampton, Bristol, Birkbeck, Nottingha...about some of the most fundamental building blocks...
...tory system of adult mice appear to play a role in...The new olfactory neurons are especially sensitive...ond to new odors. This level of flexibility sugge...uced to adapt to and integrate into other regions ...rons lost to injury or disease. The report from r...
...covered a small vertebra at a construction site ne...nlike anything in the fossil record. Scientists no...origin of an extinct line of lizards with an evolu... fully aquatic. , Turner took the remains to paleo..., but it took several years before scientists dubb...
...red how to block a molecular switch that triggers ... stroke. The Hopkins study, conducted on mice, is ...tein on the surface of nerve cells called the EP1 ...nd, known as ONO-8713, turns it off. , The findi...alternatives to anti-inflammatory drugs called COX...
Other Biology News:Grid bridges 4,800 miles for molecular repositories 2Neurons generated in the adult brain learn to respond to novel stimuli 2Missing fossil link 'Dallasaurus' found 2Missing fossil link 'Dallasaurus' found 3Missing fossil link 'Dallasaurus' found 4Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke 2Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke 3
The bench-top stand comfortably holds up to 6 Finnpipette Digital single- and multichannel pipettes. The crossbars are made of a grippy material to keep the pipettes firmly in place. Individual shelf
Lambda Protein Phosphatase ( l-PPase) is a Mn2+-dependent protein phosphatase with activity towards phosphorylated serine, threonine and tyrosine residues. It is the 221 amino-acid product of the ORF
... in Tris buffer, pH 10.2 give activity approx. 2X ...anolamine buffer, pH 9.8 give activity approx. 5X ...ned by Biuret Physical form: Lyophilized powder co...t Definition: One unit will hydrolyze 1 μmole...
Immulon 2 HB 1x8 Strip assembled, C-bottom; high binding irradiated surface to provide increased binding affinity for hydrophilic proteins and complexes.
Biology Products: