Navigation Links
Mercury Therapeutics, Inc: Lead Series of Indirect AMPK Activators Licensed to Makoto Life Sciences
Date:3/12/2008

WOBURN, Massachusetts, March 12 /PRNewswire/ -- Mercury Therapeutics, Inc. (MTI), a company that discovers and develops orally active protein kinase targeted drugs, announces that it has signed an exclusive license agreement with Makoto Life Sciences, Inc., of Cambridge, Massachusetts.

Under this agreement, MTI has licensed to Makoto its lead series of high potency activators of AMP-activated protein kinase (AMPK), a well validated drug target for the treatment of Type-2 diabetes. As part of the license, MTI will transfer all assets related to its MT-39 series of indirect AMPK activators, including all materials, research notes, synthetic routes, and the structures of over 40 compounds. MTI will advise Makoto on the continuing development of the MT-39 series.

Unlike MTI's internal R&D program, which is focused on developing small molecules that activate AMPK by direct binding, the MT-39 series of compounds are indirect AMPK activators and appear to act with high potency through a cellular pathway which has not yet been identified. The successful clarification of this pathway may lead to the development of new targets and compounds for the treatment of metabolic disease.

MTI's series of compounds were originally identified in the course of a collaboration with Aventis, a large pharmaceutical company. That relationship ended in 2004 and all rights, including the MT-39 series of compounds, reverted entirely and exclusively to Mercury. MTI subsequently launched a medicinal chemistry program targeting the MT-39 core structure, and identified a number of congeners with low nanomolar activities and efficacy in animal models of glucose metabolism. As activators of AMPK, the MT-39 series of compounds could be expected to improve glycemic control in Type-2 diabetics, and lower other risk factors associated with cardiovascular disease.

While the specific terms of the license agreement have not been disclosed, Makoto will be responsible, among
'/>"/>

SOURCE Mercury Therapeutics Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Cell Therapeutics, Inc. (CTI) to Present at 7th Annual WBBA Invest Northwest Conference
2. Cell Therapeutics, Inc. (CTI) to Report Fourth Quarter and Year-End Financial Results on March 13
3. Cell Therapeutics, Inc. to Hold Conference Call to Update on Recent Transactions and Upcoming Milestones
4. M. Scott Harris, M.D., Joins Ocera Therapeutics, Inc., as Chief Medical Officer
5. Cell Therapeutics, Inc. (CTI) Announces Cancellation of Approximately $9.1 Million of Existing Notes due 2008
6. Mersana Therapeutics, Inc. Appoints Chief Scientific Officer, Timothy B. Lowinger, Ph.D.
7. Cell Therapeutics, Inc. (CTI) Projects Zevalin(R) Sales of $15 Million With Cash Flow Breakeven for Commercial Operations in 2008
8. Cell Therapeutics, Inc. (CTI) to Present at 10th Annual BIO CEO & Investor Conference
9. Nile Therapeutics, Inc. to Present at Upcoming BIO CEO & Investor Conference
10. Velcura Therapeutics, Inc. Teams with International Discovery Sourcing Consultants to Develop New Therapeutic Molecules for Cancer and Bone Disease
11. Sonexa Therapeutics, Inc., Raises $30 Million in Series A Financing to Focus on Alzheimers Treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... , A major pan-European survey into the ... care has revealed changing trends in many important GI ... of healthcare services across the continent. The results of ... (UEG), have been announced today and led to calls ... of GI disorders across Europe ...
(Date:10/20/2014)... N.J. (PRWEB) October 20, 2014 ... the Sidney Kimmel Cancer Center at Thomas Jefferson ... , Through the Strategic Alliance Partnership program, ... OncLive will collaborate to raise awareness of the ... treatment, and other projects. Clinicians and other health ...
(Date:10/19/2014)... The Latin American hardware encryption display market ... with analysis and forecast of revenue. This market was ... to reach $2,366.8 million by 2018, at a CAGR ... the TOC of the Latin American hardware encryption market ... provided. It also provides a glimpse of the segmentation ...
(Date:10/19/2014)... October 19, 2014 The Asia-Pacific ... market in Asia-Pacific with analysis and forecast of ... Asia Pacific Bromine Market report, to get an ... provides a glimpse of the segmentation in the ... tables and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html ...
Breaking Biology Technology:Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
... - The legal wheels still have some spinning to do, ... Foundation not owning three key stem cell patents, or ... decision by United States Patent and Trademark Office ... or modified, but for the first time since University ...
... - What's the penalty for software piracy? Six men who ... Automation software will soon find out as they await sentencing ... for illegally copying the software and selling it on the Internet ... article in the Milwaukee Journal Sentinel . , ,The ...
... presidential primaries less than a year away, campaigns are ... their party's voters. Interestingly, voters are using every available ... reach the polls. , ,This election cycle may be ... and other consumer-generated content. But sifting through all that ...
Cached Biology Technology:Is Wisconsin's stem cell standing diminished? 2Is Wisconsin's stem cell standing diminished? 3Is Wisconsin's stem cell standing diminished? 4Tired of the spin? ExpertVoter website makes candidate selection easier 2Tired of the spin? ExpertVoter website makes candidate selection easier 3
(Date:10/19/2014)... household electricity access in India over the last ... total carbon emissions growth during that time, according ... Nature Climate Change ., "Energy access is ... aspects of life, including education, communication, and health," ... study. , While increased energy access is widely ...
(Date:10/17/2014)... knowledge regarding Ebola is critical and pertinent for practicing ... global outbreak and epidemic. The Journal, Disaster Medicine ... issue, Ebola Virus and Public Health, to surround the ... this critical societal moment. , On October 17, ... Clinicians . The primer was prepared by Dr. Eric ...
(Date:10/16/2014)... constantly wages war on the human body. Battles ... stalemate. In pancreatic cancer, this stalemate—known as tumor ... aggressively malignant, a phenomena that is poorly understood. ... the laboratory of Salvatore Torquato, a Professor of ... conditions surrounding tumor dormancy and the switch to ...
Breaking Biology News(10 mins):Improved electricity access has little impact on climate change 2Modeling tumor dormancy 2
... For the first time in nearly 50 years, ... rediscovered in the San Bernardino National Forest,s San Jacinto ... suitability of sites to re-establish frogs and scientists from ... natural history expedition both rediscovered the rare mountain yellow-legged ...
... , VILNIUS, Lithuania, July 27 ... identification technologies provider, announced today their inclusion as the core ... Issuance System. MegaMatcher SDK multi-biometric technology ... PT. Berca Hardayaperkasa, to develop a distributed passport ...
... - Temperature explains much of why cold-blooded organisms ... at higher latitudes than at lower latitudes, according to ... the National Academy of Sciences ( PNAS ) ... Santiago Salinas, both of Stony Brook University,s School of ...
Cached Biology News:Biologists rediscover endangered frog population 2Biologists rediscover endangered frog population 3Biologists rediscover endangered frog population 4Indonesia Now Using MegaMatcher Biometric Technology in Integrated Passport Issuance System 2Indonesia Now Using MegaMatcher Biometric Technology in Integrated Passport Issuance System 3Indonesia Now Using MegaMatcher Biometric Technology in Integrated Passport Issuance System 4Warmer environment means shorter lives for cold-blooded animals 2