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Memory Pharmaceuticals Initiates Phase 2a Trial of MEM 3454 in Cognitive Impairment Associated with Schizophrenia
Date:12/20/2007

MONTVALE, N.J., Dec. 20 /PRNewswire-FirstCall/ -- Memory Pharmaceuticals Corp. (Nasdaq: MEMY) today announced dosing of the first subject in a randomized, double-blind, placebo-controlled Phase 2a clinical trial of MEM 3454, the Company's lead nicotinic alpha-7 receptor partial agonist, in cognitive impairment associated with schizophrenia (CIAS). The trial is designed to assess the safety, tolerability and cognitive effects of three doses of MEM 3454 in patients with CIAS. There are currently no drugs approved to treat CIAS.

"Cognitive impairment is a major component of schizophrenia that contributes to patients' inability to function," stated Stephen R. Murray, M.D., Ph.D., Chief Medical Officer of Memory Pharmaceuticals. "There is a strong rationale supporting the utility of MEM 3454 in CIAS, including the efficacy findings from our recently completed positive Phase 2a clinical trial of MEM 3454 in Alzheimer's disease. Given these findings, we are excited to assess the potential of MEM 3454 to improve cognitive impairments experienced by patients with schizophrenia. We currently expect to complete this trial in the fourth quarter of 2008."

The trial will enroll approximately 160 patients with stable schizophrenia who are receiving atypical antipsychotic therapy. Subjects will be randomized to receive 5 mg, 15 mg or 50 mg of MEM 3454 or placebo once daily for a period of eight weeks. The primary objective of the trial is to assess the effectiveness of MEM 3454 in CIAS using the MATRICS Consensus Cognitive Battery (MCCB). Secondary objectives include measures of other symptoms of schizophrenia and functional capacity.

Roche has an option to secure a worldwide, exclusive license to develop and commercialize MEM 3454 u
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SOURCE Memory Pharmaceuticals Corp.
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