Navigation Links
Membrane complexes take flight
Date:6/12/2008

began to think of ways of studying these most challenging assemblies.

Dr Nelson Barrera a post-doctoral researcher in Chile, though experienced in membrane biochemistry, was a new recruit to mass spectrometry. He was largely unaware of the difficulties that had previously been encountered and approached the problem in a new way. Rather than trying to remove the detergent (used to keep the protein intact in solution once outside the natural membrane) he maintained the detergent in unusually high amounts. He then deliberately destroyed this protective detergent layer once in the gas phase. This allowed him to liberate the intact assembly. He was also able to remove units from the modular assembly in the gas phase, just as in solution.

Professor Robinson adds: "I am very excited by this finding given the importance of membrane complexes in guarding the entrance and exit to cells. The type of proteins we have been studying, for example, are involved in drug resistance in cancer cells and antibiotic resistance of bacteria.

"I look forward to exploiting this discovery to the full; not only in characterising the many membrane complexes for which controversy exists but also in discovering new assemblies and in investigating the potential of this approach in drug discovery."

Professor Paula Booth, at the University of Bristol added: "This is a major advance that helps us understand how nature constructs cellular life. The membrane wall of cells is a precision-made, complex and highly regulated structure. We are now much better equipped to understand this incredible, natural self-assembly feat."


'/>"/>

Contact: Genevieve Maul
genevieve.maul@admin.cam.ac.uk
44-012-233-32300
University of Cambridge
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Novel Approach to Treat Alzheimers and Other Diseases Offered by Targeting Cell Membrane RAFTS
2. Ames Laboratory researchers solve fuel-cell membrane structure conundrum
3. NASA Goddard Space Flight Centers carbon nanotube manufacturing technology wins Nano 50 Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rcv4lq/gene_therapy ... Therapy Market, 2015 - 2025" report to their ... report provides an extensive study on the marketed and ... carried out in this field for over a decade ... in Asian markets; one approved in the EU). There ...
(Date:3/3/2015)... California (PRWEB) March 03, 2015 Crown ... service company, has launched a new Life Science division ... for preclinical research. , The first products released ... isotype controls, and soon to be released in vivo ... will continue to expand their life science portfolio with ...
(Date:3/3/2015)... March 3, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ... scientific journal, Expert Opinion on Biological Therapy , ... Zhenggang Zhang , at the Henry Ford Hospital ... Thymosin beta 4 (TB4) has the capacity to promote ... or more post-injury, leading to neurological recovery in each ...
(Date:3/3/2015)... Liberty Corner, New Jersey (PRWEB) March 03, 2015 ... in NJ, has announced today that it has ... DE. Terms of the transaction were not ... engineering consulting services to the energy sector including ... gas, alternative energy, and fossil and nuclear power ...
Breaking Biology Technology:Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 2Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 3Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 5Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 6Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 7Crown Bioscience Launches Life Science Product Catalog 2Researchers at Henry Ford Hospital Propose Thymosin Beta 4 as Novel Way to Treat Neural Injury and Neurodegenerative Diseases 2Researchers at Henry Ford Hospital Propose Thymosin Beta 4 as Novel Way to Treat Neural Injury and Neurodegenerative Diseases 3
... Oct. 1 Biomaxx Systems Inc. (Other,OTC: BMXSF), ... our membership,with Bioenergy Australia for 2007. BioMaxx Systems ... in Australia as a result of,our involvement with ... forum established in 1997 to promote renewable,energy solutions. ...
... Boston Scientific,Corporation (NYSE: BSX ) will webcast its ... September 30, 2007 on Friday,October 19, at 8:00 a.m. ... Tobin, President and Chief Executive,Officer, Paul LaViolette, Chief Operating ... Officer. The live webcast and archived replay of ...
... Trubion Pharmaceuticals Inc.,(Nasdaq: TRBN ) ... abstract for TRU-015 for rheumatoid arthritis (RA), ... College of Rheumatology (ACR),Annual Scientific Meeting. This ... Association of Rheumatology Health Professionals (ARHP) Annual,Scientific ...
Cached Biology Technology:Biomaxx Systems Inc. Renews Membership With Bioenergy Australia 2Boston Scientific to Webcast Conference Call Discussing Third Quarter Financial Results 2Trubion Pharmaceuticals Announces Upcoming Presentations at American College of Rheumatology Annual Scientific Meeting 2
(Date:2/24/2015)... NEW YORK , Feb. 24, 2015 This ... Thousands. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... America . Annual estimates and forecasts are provided for ... is provided for these markets. Market data and analytics are ...
(Date:2/23/2015)... Conn. , Feb. 23, 2015 NXT-ID, ... or the "Company"), a biometric authentication company focused on ... has filed provisional patent 62114357 for DISTRIBUTED ... this patent, NXT-ID introduces a new groundbreaking payment method. ... the payment account may only be accessed if both ...
(Date:2/13/2015)... 2015 ACT Genomics Co., Ltd., a ... transform cancer genomic information into precision diagnosis and ... raised US$ 8 million in the its first private ... Taipei, Taiwan , ACT Genomics has developed ... aim to implement next generation sequencing (NGS) and ...
Breaking Biology News(10 mins):World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3ACT Genomics Raises $8 Million in its First Private Funding Round 2
... In an article published in this month,s issue of ... School of Medicine (BUSM) stress the importance of physicians ... in order to make accurate health assessments for both ... existing regulatory guidelines set a standardized risk assessment of ...
... the Society,s highest honor, the 2013 Wallace H. Coulter ... David Weatherall, MD, of the University of Oxford for ... discoveries, visionary translational research leadership, and a passion for ... care for thousands throughout the developing world. ...
... An international research team led by University of Pittsburgh Cancer ... entering a state of cellular sleep, cancer drugs are more ... ,The findings, which will be published in the August 15 ... available online, are the first to show that it is ...
Cached Biology News:Study finds physicians need to better recognize use of herbal supplements while breastfeeding 2Professor Sir David Weatherall, M.D., recieves 2013 Wallace H. Coulter Award 2Professor Sir David Weatherall, M.D., recieves 2013 Wallace H. Coulter Award 3Professor Sir David Weatherall, M.D., recieves 2013 Wallace H. Coulter Award 4UPCI researchers target 'cell sleep' to lower chances of cancer recurrence 2
... instrument can be used as a fully ... Manager Software provides the means to record ... instrument. These data can then be copied ... as Microsoft Excel or Lotus 123, or ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... Oligo Microarray Kit (V2), 2 x ... characterize expression of many thousands of ... during important biological processes. Each microarray ... known ORFs from the S288C strain ...
... an intuitive, easy-to-use operating environment ... data handling, and integration with ... include data acquisition, re-analysis, custom ... both standalone and network environments. ...
Biology Products: