Navigation Links
Medivation Presents New Data on Dimebon's Novel Mechanism of Action
Date:12/9/2008

pment and progression. Similarly, mitochondrial dysfunction has been linked in the published literature to the progression of Huntington's disease.

Preclinical Study Results

As synapse formation is dependent on mitochondrial function and synapse loss is a major characteristic observed in the brain tissue of individuals with Alzheimer's disease, researchers evaluated the effects of Dimebon on neurite outgrowth, an important aspect of synapse formation.

Results of the study showed that Dimebon induced a statistically significant increase in neurite outgrowth from cortical, hippocampal and spinal cord neurons. Dimebon's potent effect on neurite outgrowth was seen at low concentrations and was comparable to that achieved with maximally effective concentrations of a potent growth factor (Brain Derived Neurotrophic Factor). Study results also showed that Dimebon reduced mitochondrial impairment in the setting of cellular stress. Specifically, Dimebon treatment mitigated mitochondrial impairment induced by beta amyloid.

Dimebon's effect on improving mitochondrial dysfunction has been confirmed previously in the independent laboratory of Maria Ankarcrona, Ph.D., associate professor at the Karolinska Institutet in Sweden. Additional data about Dimebon's potential novel mechanism of action were presented in November at the Society for Neuroscience's "Neuroscience 2008" conference in Washington, D.C.

Preclinical data also have been presented that suggest that Dimebon works through a different mechanism of action than other drugs that focus on targets implicated in cognition and memory loss, such as cholinesterase inhibition. In these experiments, Dimebon was shown to be a weak cholinesterase inhibitor, and additional data from binding assays showed that Dimebon did not have strong affinity to other standard targets. This suggests that Dimebon's potential novel mitochondri
'/>"/>

SOURCE Medivation, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Medivation Announces Participation in RBC Capital Markets 2008 Healthcare Conference
2. Medivation Reports Third Quarter 2008 Financial Results and Provides Corporate Update
3. Medivation Announces Third Quarter 2008 Teleconference and Webcast on November 10, 2008
4. Medivation Announces Expiration of Hart-Scott-Rodino Waiting Period for Collaboration With Pfizer
5. Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients
6. Medivation Receives Corporate Achievement Award From Huntingtons Disease Society of America
7. Medivation to Host Conference Call at 8:30 a.m. Eastern Time Tomorrow to Discuss Partnering Plans for Dimebon
8. Medivation Announces Participation in Upcoming Conferences
9. Medivation Reports Second Quarter 2008 Financial Results and Provides Corporate Update
10. Medivation Announces Second Quarter 2008 Teleconference and Webcast on August 11, 2008
11. Medivation Announces Presentation at the BMO Capital Markets 2008 Focus on Healthcare Conference on August 5
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... and Hershey, PA (PRWEB) December 19, 2014 ... BJCT), a leading developer and manufacturer of needle-free ... into an agreement with Immunomic Therapeutics, Inc. (“ITI”) ... needle-free injection device with its LAMP™ vaccine platform. ... option for an exclusive Worldwide license to the ...
(Date:12/19/2014)... 19, 2014 Charm Sciences is pleased ... the Detection of Aflatoxin M1 in raw commingled milk ... third party validation. The peer reviewed report of the ... Institute for Agricultural and Fisheries Research (ILVO-T&V) has been ... Aflatoxin B1, the most toxic aflatoxin and a known ...
(Date:12/19/2014)... 19, 2014 BioPlus Specialty Pharmacy ... announces the promotion of Nick Maroulis, Pharm.D. to the ... Services. , In this position, Dr. Maroulis will ... managing the directors of our multi-site pharmacies as the ... 1997 and during that time he has served in ...
(Date:12/19/2014)... 19, 2014 Naurex Inc., a biopharmaceutical company ... diseases of the central nervous system, today announced that ... officer, will present at the 33 rd annual ... place at 3:00 p.m. PST on Tuesday, January 13, ... San Francisco, Calif. About ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... (R) (lacosamide) C-V, a new antiepileptic drug (AED), ... week of June 2009. Vimpat was approved by ... the use as an add-on therapy for the treatment ... with epilepsy.(Photo: http://www.newscom.com/cgi-bin/prnh/20090526/NY22555 )Vimpat approval is ...
... Inc. (Nasdaq: MEDX ) is scheduled to host ... Time on Tuesday, June 2, 2009. Geoffrey M. Nichol, M.B.Ch.B., ... an update and recent highlights from Medarex,s pipeline.The webcast of ... Investor Relations section of Medarex,s website at www.medarex.com ...
... advancements in producing cellulosic ethanol and the fuel,s promise for the future ... Sao Paulo, Brazil. , ... Sioux Falls, S.D. (Vocus) May 26, 2009-- ... future will be highlighted by POET next week at Ethanol Summit 2009 ...
Cached Biology Technology:Vimpat(R) (lacosamide) C-V, a New Antiepileptic Drug (AED), To Be Available in U.S. Pharmacies 2Vimpat(R) (lacosamide) C-V, a New Antiepileptic Drug (AED), To Be Available in U.S. Pharmacies 3Medarex to Host Clinical Program Update Conference Call on Tuesday, June 2, 2009 2POET to Outline Cellulosic Ethanol's Present, Future at Brazil's Ethanol Summit 2009 2
(Date:12/10/2014)... , December 9, 2014 ... BCARD Platform   ... meeting scheduling solutions for business-to-business (B2B) events, today ... leader in mobile near-field communication (NFC), Bluetooth low ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will ...
(Date:12/3/2014)... , Dec. 2, 2014 As part of ... Inception Technologies is pleased to announce the release of ... customers to collect the workforce data that they need. ... have been left by existing readers. Many such devices ... connectivity and modern technology. Older models force users to ...
(Date:11/21/2014)... JOSE, Calif. , Nov. 20, 2014   ... global leader in microcontroller (MCU) and touch technology solutions, ... digital temperature sensors with the widest V cc ... delivers higher temperature accuracy and faster I 2 C ... registers and serial EEPROM memory making them ideal for ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Inception Technologies to Release New Biometric Reader 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... and research centers from across the country came together ... it to hazardous materials experts and public health officials. ... North Carolina at Chapel Hill's Marine Sciences Program and ... for Supercomputing Applications (NCSA), played a key role in ...
... The world's three leading public repositories for DNA and ... the 'letters' of the genetic code] of sequence. Thanks ... way for the global exchange of many types of ... Sequence Database Collaboration [INSDC, http://www.insdc.org ] - EMBL ...
... A team of scientists at the University of Chicago has ... map when genes are switching off and on in a ... changes in its environment. , The technique, which is announced ... the National Academy of Sciences, could help scientists discover new ...
Cached Biology News:UNC computer, marine scientists collaborate to predict flow of toxic waters from Katrina 2UNC computer, marine scientists collaborate to predict flow of toxic waters from Katrina 3Public collections of DNA and RNA sequence reach 100 gigabases 2Public collections of DNA and RNA sequence reach 100 gigabases 3Scientists devise way to measure RNA synthesis on the fly in a live cell 2
Immulon 2 HB 1x8 Strip assembled, C-bottom; high binding irradiated surface to provide increased binding affinity for hydrophilic proteins and complexes....
... Vapor Trap is specifically designed for ... such as DMSO and DMF in ... temperature refrigeration system set at -5 ... for DMSO, while completely eliminating the ...
96 Well Plate EB, RE bottom; high binding irradiated surface to provide increased binding affinity for hydrophilic proteins and complexes. Guaranteed coefficient of variation (CVs)....
The Holten mini vertical flow workbench provides a particle-free environment for sample protection against airborne contaminants....
Biology Products: