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Medivation Announces Presentation of Positive MDV3100 Clinical Data in Castration-Resistant Prostate Cancer Patients
Date:4/14/2008

- Data Presented at AACR Annual Meeting Late-Breaking Clinical Trials

Session -

SAN FRANCISCO and SAN DIEGO, April 14 /PRNewswire-FirstCall/ -- Medivation, Inc. (Nasdaq: MDVN) today announced that data from an ongoing Phase 1-2 clinical trial showed that the Company's novel androgen receptor antagonist, MDV3100, continued to reduce serum levels of prostate specific antigen (PSA), a marker of tumor growth, in the lowest expanded dose group tested after three months of treatment. Over-expression of the androgen receptor is believed to contribute to the progression of castration-resistant prostate cancer. These observed declines were consistent with the inhibition of androgen receptor signaling. MDV3100 continued to be well-tolerated in all dose groups.

The data were presented as part of a special late-breaker clinical plenary session at the American Association for Cancer Research (AACR) Annual Meeting in San Diego. The oral presentation, entitled "Phase I-II study of the androgen receptor antagonist MDV3100 in castration-resistant prostate cancer," was presented by Howard Scher, M.D., chief of the Genitourinary Oncology Service and the D. Wayne Calloway Chair in Urologic Oncology at Memorial Sloan-Kettering Cancer Center in New York.

"The declines in PSA observed thus far and the general tolerability of this treatment are encouraging, and further data currently being generated will clarify its role as a potential therapy for patients with castration-resistant prostate cancer," said Dr. Scher.

"We continue to be encouraged by the results observed at this low dose of MDV3100. In addition, we are testing higher doses to assess a dose response," said David Hung, M.D., president and
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SOURCE Medivation, Inc.
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