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Medical College of Wisconsin and Cellular Dynamics Awarded NHLBI Grant Using Human Induced Pluripotent Stem Cells
Date:7/5/2011

pertension.  HyperGEN is unique because it is family-based, includes both Caucasians and African-Americans and is one of the largest genome-wide association studies (GWAS) with extensive clinical data available.  

"This grant builds on years of our research to identify genes for this disease. We now have the wonderful opportunity to capitalize on the latest stem cell technology to study human heart cells in the laboratory," said Ulrich Broeckel, MD, Professor of Pediatrics, Medicine and Physiology at MCW and Associate Director at the Children's Research Institute.  "This technology is truly revolutionary since each cell line stands for an individual patient, and we can now start to study the unique disease mechanisms and test new treatments and drugs based on each individual's unique genetic makeup.  This grant also shows the strength of collaborations between academic investigators and a company which leads to cutting edge research."

"Funding of this grant will enable Cellular Dynamics to generate an unprecedented 250 human iPSC lines as well as heart cells derived from those lines," said Emile Nuwaysir, Chief Operating Officer of CDI.  "Until now, functional studies for left ventricular hypertrophy have been limited because human primary cardiomyocytes, or heart cells taken from living tissue, were not available for functional analysis.  Human iPSC technology provides a solution to this problem.  CDI's human iPSC-derived heart cells, iCell® Cardiomyocytes, exhibit properties highly similar to human primary cells and thus are a relevant model system for the required functional analysis. In addition, CDI is the only company with the capability to manufacture iPSCs and differentiate them in large numbers and at high quality and purity from a typical, standard blood draw, thus enabling MCW to perform this series of experiments. We are particularly
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