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Medgenics Announces Encouraging Preliminary Data For Phase I/II Clinical Trial of EPODURE In Renal Anemia

lobin levels seen in the 2 subjects currently participating in the trial suggest that immunogenicity issues have not been encountered thus far. Immunogenicity is the triggering of a natural immune response by the human body which could halt the protein production of the Biopump and which is thought to have curtailed the duration of EPO delivery in the Company's previous Phase I Clinical Trials, in 2003. In the previous trial, elevated hemoglobin levels were not seen despite dosage levels at least three times higher than those used thus far in the current trial. The Directors believe that the elevated hemoglobin levels and the apparent immune acceptance of the implanted EPODURE Biopumps, should be viewed positively, although more definitive conclusions can only be drawn once more subjects have been tested for a longer period.

Medgenics' Biopump is a unique tissue-based platform technology that processes a toothpick sized sliver of the inner layer of the subject's skin and is designed to provide sustained-action protein therapy for the treatment of a range of chronic diseases. As stated in the Company's Admission Document London AIM Exchange, the Directors believes that the Biopump platform technology will provide a wide range of advantages over existing protein therapies that will appeal and offer benefits to doctors, patients and third party payers (e.g. medical insurers). These advantages include:

-- Increased efficacy

-- Improved safety

-- Reversible treatment

-- Reduced side effects

-- Lower costs

-- Elimination of frequent injections

-- Extended treatment to undertreated populations

Additional subjects are being actively recruited for this study taking place at Hadassah Hebrew University Hospital in Jerusalem, Israel, which aims to test the technology on up to 30 subjects by the end of 2009.

These initial results will be presented at Renal Week 2008, the American Society of Nephrologist

SOURCE Medgenics, Inc.
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