Navigation Links
Medarex And PharmAthene Announce New Therapeutic Data for Anthrax Anti-Toxin, Valortim(R)
Date:10/28/2008

d/or a positive ECL were used to identify an active infection that required therapeutic intervention, and animals were then treated with either Valortim or saline (control).

In this study, 94 percent (30/32) of the animals were subsequently shown to be bacteremic at the time of treatment. Twelve of the NZW rabbits were treated with an intravenous (IV) 10 mg/kg dose of Valortim, 8 were treated with a 20 mg/kg IV dose of Valortim, and 12 were treated with IV saline in the control group. Study findings showed that 100 percent (8/8) of the 20 mg/kg Valortim-treated animals survived compared to 83 percent (10/12) in the 10 mg/kg Valortim-treated group and 8 percent (1/12) in the control group.

About Valortim

Valortim (MDX-1303) is a fully human monoclonal antibody designed to protect against and treat anthrax infection, including inhalation anthrax, the most lethal form of illness in humans caused by the Bacillus anthracis bacterium. The investigational antibody is designed to target a protein component known as the anthrax protective antigen (PA) of the lethal toxin complex produced by the bacterium. The anthrax protective antigen is believed to initiate the onset of the illness by attaching to cells in the infected person, and then is believed to facilitate the entry of additional destructive toxins into the cells. Valortim is designed to target anthrax protective antigen and protect the cells from damage by the anthrax toxins.

As previously presented, Valortim has been administered intravenously and intramuscularly to healthy human volunteers in a completed Phase 1 study, was well tolerated at doses as high as 20 mg/kg (IV), and was not immunogenic. Pharmacokinetic analysis suggested that doses as low as 1 mg/kg resulted in circulating levels of antibody after a month, with a similar potency for neutralizing anthrax toxin in vitro as was seen with serum obtained from subjects who had been vaccinated with anthrax vaccine.

Preclinical
'/>"/>

SOURCE Medarex, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Medarex to Present at Thomas Weisel Partners Healthcare Conference 2007
2. Medarex to Present at the Bear Stearns 20th Annual Healthcare Conference
3. Medarex Announces Extension of Broad Antibody Development Relationship with Centocor
4. Medarex to Present at the A.G. Edwards 2nd Annual Emerging Growth Conference
5. Medarex to Present at the UBS Global Life Sciences Conference
6. Medarex Announces Election of Marc Rubin as New Board Member
7. Medarex to Present at the 26th Annual JPMorgan Healthcare Conference
8. Medarex Announces Completion of Sale of Shares in Genmab A/S
9. Medarex to Announce 2007 Fourth Quarter and Year-End Financial Results on Tuesday, February 26, 2008
10. Medarex to Present at the Susquehanna Financial Group Healthcare Conference
11. Medarex Announces Presentations at Annual Meeting of the American Association for Cancer Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 19, 2014  Nektar Therapeutics (NASDAQ: ... characterizing the analgesic profiles of a series of ... agonist molecules. The preclinical research candidates were created ... The analgesic properties of kappa receptor ... 1,2 Kappa opioid receptors are expressed in ...
(Date:9/19/2014)... 19, 2014 ... ) has announced the addition of the  "Micro ... to their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... of the fastest-growing segments in the chromatography market. ... 2013, and expected to reach $2.0 billion by ...
(Date:9/18/2014)... -- About POCT POCT, also ... laboratory. It helps in making fast clinical decisions, ... POCT is gaining popularity due to the increasing ... diabetes, heart disease, and obesity. It is generally ... minimize errors during the diagnosis of patients. POCT ...
(Date:9/18/2014)... 2014 Texas Governor Rick Perry, ... A&M Health Science Center CEO Brett Giroir, M.D., ... and Human Services (HHS), State of Texas and ... influenza vaccine manufacturing facility in Bryan, Texas, which ... the Texas A&M Biocorridor – a rapidly evolving ...
Breaking Biology Technology:Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Micro Market Monitor : Global Pre-packed Chromatography Columns 2POCT Market in China 2014-2018 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4
... ,,, Many different tissue types on ... , Carolyn Thomas ,Stratagene , Stratagenes Complete ... refinement of tissue array technology through optimized,tissue ... morphology,antigenicity of proteins, and nucleic acid reactivity. ...
... Characterize gene distribution in your cDNA , ... introduce six pairs of control RT-PCR primers that ... various expression levels. These,primer sets provide insight into ... classes of transcripts and whether full-length or near ...
... Better temperature uniformity allows for better control of ... Moores Jason Capodanno ,Michael Rahilly ,Stratagene , ... ,produces consistent PCR results in every well. The ... techniques that are optimized for block,temperature uniformity. In ...
Cached Biology Technology:Innovative Tissue Array Technology for High-Throughput Screening of Gene,Expression 2Innovative Tissue Array Technology for High-Throughput Screening of Gene,Expression 3Innovative Tissue Array Technology for High-Throughput Screening of Gene,Expression 4Innovative Tissue Array Technology for High-Throughput Screening of Gene,Expression 5Control RT-PCR Primers for Human Gene Transcripts with Varying Abundance 2Control RT-PCR Primers for Human Gene Transcripts with Varying Abundance 3Control RT-PCR Primers for Human Gene Transcripts with Varying Abundance 4Control RT-PCR Primers for Human Gene Transcripts with Varying Abundance 5Control RT-PCR Primers for Human Gene Transcripts with Varying Abundance 6Effects of Thermal Cycler Well-To-Well Temperature Uniformity on PCR Results 2Effects of Thermal Cycler Well-To-Well Temperature Uniformity on PCR Results 3Effects of Thermal Cycler Well-To-Well Temperature Uniformity on PCR Results 4Effects of Thermal Cycler Well-To-Well Temperature Uniformity on PCR Results 5
(Date:9/19/2014)... dinosaurs a newly discovered hadrosaur with a ... Rhinorex condrupus by paleontologists from North ... in what is now Utah approximately 75 million ... Rhinorex, which translates roughly into "King Nose," was ... Cretaceous hadrosaurs like Parasaurolophus and Edmontosaurus. Hadrosaurs are ...
(Date:9/19/2014)... by researchers from several Harvard University labs in ... and aspiring researchers with the intellectual raw materials ... from soft, flexible materials. , With the advent ... advances in manufacturing technology, soft robotics is emerging ... from conventional rigid robot design, but working with ...
(Date:9/19/2014)... the unique bioelectric signaling system of the electric fish, ... The OU researcher is working to understand how these ... used to map the world around them. Electric ... discharges a second throughout their lives. The energetic ... necessary for survival. , "There is evidence that electric ...
Breaking Biology News(10 mins):New hadrosaur noses into spotlight 2Soft robotics 'toolkit' features everything a robot-maker needs 2
... researchers sometimes need to put on the hip waders, pull ... compares to the real world. According to a Stanford University ... of Science, Mother Nature is more predictable than lab experiments ... stickleback, nature took advantage of the same genetic trick time ...
... scientists report in the journal Nature that the "missing" ... up by splicing together sequences in distant parts of ... Dieter Söll in the Department of Molecular Biophysics and ... with a known genome sequence. Nanoarchaeum equitans, is a ...
... the University of Cincinnati (UC) College of Medicine have ... stroke known as cerebral vasospasm. , A constriction of ... occurs three to 10 days following a massive brain ... who survive the initial stroke develop vasospasm, and 40 ...
Cached Biology News:Same mutation aided evolution in many fish species, Stanford study finds 2Same mutation aided evolution in many fish species, Stanford study finds 3Researchers find missing genes of ancient organism 2Researchers discover molecule that causes secondary stroke 2
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... in plasma from juvenile or male fish is ... chemicals (EDCs) with estrogenic effects in fish. Quantification ... for the estrogenic effects of EDCs in fish. ... double-antibody immunometric (sandwich) EIA for analyzing Vtg in ...
... synthetic peptide whose sequence is from rat SCAMP 5. The ... - N(217) - Q - P - Q - T - ... - N - Y - T - Y - S - ... control experiments with the polyclonal antibody that reacts with this product ...
... a novel target for which no antibody exists? ... custom antibodies for a variety of pharmaceutical, biotech ... to put our technology and expertise in antibody ... to our patented RabMAb development technology , High ...
Biology Products: