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Medarex And PharmAthene Announce New Therapeutic Data for Anthrax Anti-Toxin, Valortim(R)
Date:10/28/2008

and we look forward to working collaboratively with the Department of Health and Human Services to fulfill a critical need in the Nation's arsenal to combat the threat of anthrax."

"We are pleased to have been able to refine this model for therapeutic intervention in anthrax infection, further defining the potential efficacy of Valortim in anthrax disease," commented Dr. Lowy. "Animal modeling for therapeutic intervention in anthrax infection (in contrast to post-exposure prophylaxis) has been challenging because of the variability in onset time to disease after exposure and the rapidity of disease progression once symptoms are manifest. We used a rapid approach to identify animals with active disease, and our results showed that the animals designated for treatment proved to have bacteria circulating in their blood, supporting the accuracy of the approach and that Valortim had impressive activity in this setting. This study, along with others being conducted by our partner PharmAthene, may help to define an optimal and reproducible approach to evaluate therapeutic agents for anthrax disease in general, as well as Valortim in particular."

Details of the study

The pilot study, funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health (NIH), was designed to attempt to refine the New Zealand White (NZW) rabbit model as a predictive therapeutic model for anthrax inhalation disease, and to assess the efficacy of Valortim in this model. In the study, 32 adult NZW rabbits were exposed by aerosol to Ames anthrax spores. Beginning 12 hours post-exposure, animals were evaluated hourly for changes in temperature, and every 6 hours blood samples were collected to assess bacteremia and protective antigen in blood. Samples were analyzed for protective antigen via a rapid electrochemiluminescent immunoassay (ECL), and bacteremia was evaluated by 24- hour culture. A significant increase in body temperature an
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SOURCE Medarex, Inc.
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