MedImmune Presents Data at AAP National Conference & Exhibition Demonstrating Burden of R...(eater than 10-percent of all specimens t...)

for RSV are positive. Traditionally, widespread activity has been

defined as occurring between November and March, yet there is growing

evidence that RSV outbreaks vary by geographic region and from year to

year. This prospective, multi-center surveillance study examined data

recorded in the high-volume outpatient setting of hospital emergency

departments (in contrast to hospital inpatient data typically used to

demonstrate the burden of RSV-associated illness) to analyze RSV

activity in September and October over two consecutive years.

-- Identifying Residual Risk of Severe RSV Disease Among Unprophylaxed

Preterm Infants (Poster #36) Doris Makari, MD, Friday, October 10,

2008, from 6:00 - 6:30 p.m.

BACKGROUND: The majority of preterm infants are born between 32 and 35

weeks gestation; RSV prophylaxis with Synagis(R) (palivizumab) has

resulted in significant reductions in RSV-associated hospitalizations

(RSVH) among this population. The use of Synagis has been restricted,

however, due to cost concerns associated with prophylaxis. This

retrospective cohort study examined whether risk factors outside of

current AAP Red Book guidelines - young chronological age, smoking and

overcrowding - could identify a subset population of infants born

between 32 and 35 weeks gestation that may be at high risk for RSVH,

but not currently recommended for prophylaxis under the AAP guidelines.

-- Cost Implications of Expanding Risk Factors for RSV Prophylaxis with

Palivizumab for Infants 32-35 Weeks Gestation (Poster #29) - Leonard

Krilov, MD, Friday, October 10, 2008 from 6:00 - 6:30 p.m.

BACKGROUND: AAP Red Book guidelines recommend RSV prophylaxis with

Synagis for infants born between 32
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