Navigation Links
Measuring blood flow to monitor sickle cell disease
Date:2/29/2012

(Cambridge, Mass.) -- More than 60 years ago, scientists discovered the underlying cause of sickle cell disease: People with the disorder produce crescent-shaped red blood cells that clog capillaries instead of flowing smoothly, like ordinary, disc-shaped red blood cells do. This can cause severe pain, major organ damage and a significantly shortened lifespan.

Researchers later found that the disease results from a single mutation in the hemoglobin protein, and realized that the sickle shape seen more often in people from tropical climates is actually an evolutionary adaptation that can help protect against malaria.

However, despite everything scientists have learned about the disease, which affects 13 million people worldwide, there are few treatments available. "We still don't have effective enough therapies and we don't have a good feel for how the disease manifests itself differently in different people," says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science at MIT.

Bhatia, MIT postdoc David Wood, and colleagues at Harvard University, Massachusetts General Hospital (MGH) and Brigham and Women's Hospital have now devised a simple blood test that can predict whether sickle cell patients are at high risk for painful complications of the disease. To perform the test, the researchers measure how well blood samples flow through a microfluidic device.

The device, described March 1 in the journal Science Translational Medicine, could help doctors monitor sickle cell patients and determine the best course of treatment, Bhatia says. It could also aid researchers in developing new drugs for the disease.

Monitoring blood flow

Sickle cell patients often suffer from anemia because their abnormal red blood cells don't last very long in circulation. However, most of the symptoms associated with the disease are caused
'/>"/>

Contact: Kimberly Allen
allenkc@mit.edu
617-253-2702
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Reportlinker Adds Cancer Vaccines: Measuring Market Potential
2. Measuring the electrical properties of nano-crystals
3. Ion armageddon: Measuring the impact energy of highly charged ions
4. New measuring techniques can improve efficiency, safety of nanoparticles
5. FDA Grants Full Approval of PROCLEIX(R) ULTRIO(R) Blood Screening Assay
6. Biotest Diagnostics Receives FDA Clearance for Full Line of Traditional Blood Bank Reagents
7. Limbs saved by menstrual blood stem cells
8. Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes
9. Human Trial Results Show Plant Extract Tops Drug at Regulating Blood Sugar Levels; Huge Market Seen for Newly Developed Food Additive Emulin™
10. No Blood Needed Thanks to Innovative Medical Technology
11. The Modern DeBakey VAD™ To Be Introduced For the First Time in the U.S. : HeartAssist 5™ Pediatric VAD Features Industry Exclusive Direct Blood Flow Measurement System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... MA (PRWEB) December 19, 2014 Charm ... MRLAFMQ test for the Detection of Aflatoxin M1 in ... to receive independent third party validation. The peer reviewed ... Unit of the Institute for Agricultural and Fisheries Research ... Group. , Aflatoxin B1, the most toxic aflatoxin ...
(Date:12/19/2014)... Ill. , Dec. 19, 2014 Naurex ... develop novel drugs for diseases of the central nervous ... president and chief executive officer, will present at the ... Riedel,s presentation will take place at 3:00 p.m. PST ... Francis in San Francisco, Calif. ...
(Date:12/19/2014)... 19, 2014 Bina Technologies, Inc. (Bina, ... they have been acquired by Roche (SIX: RO, ROG; ... held company that provides a big data platform for ... data for the academic and translational research markets.  Bina ... will continue to focus on development of their innovative ...
(Date:12/19/2014)... DUBLIN , Dec. 19, 2014 Research ... announced the addition of the "Technology Innovations ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... Innovations in Smart Fabrics" offers a detailed assessment ... Key Findings: 1. ...
Breaking Biology Technology:Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3Technology Innovations in Smart Fabrics (Technical Insights) 2
... , STOCKHOLM, ... European Investment Fund (EIF) has entered into a,co-investment agreement ... Karolinska Development and used to invest in the company,s,portfolio ... to invest 26.7 M Euros in the co-investment fund. ...
... Most people would like to be able to charge ... not too often. A recent discovery made by UC ... that could do just this. In recent ... Bandaru, a professor in the UCSD Department of Mechanical ...
... , BETHESDA, Md., Nov. 19 ... for diabetes therapy, and a provider of technical and regulatory ... today it closed the previously reported $6.3 million registered direct ... stock and warrants to purchase up to 1,104,348 additional shares ...
Cached Biology Technology:Karolinska Development and EIF Start Landmark Co-Investment Fund for Life Science Innovation 2Karolinska Development and EIF Start Landmark Co-Investment Fund for Life Science Innovation 3Nanotube defects equal better energy and storage systems 2Spherix Announces the Closing of $6.3 Million Registered Direct Offering 2Spherix Announces the Closing of $6.3 Million Registered Direct Offering 3
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... of the "Micro Market Monitor: North America Perimeter ... http://photos.prnewswire.com/prnh/20130307/600769 The ... at a CAGR of 3.6% from 2014 to 2019. ... this market, Canada is expected ...
(Date:12/17/2014)... , Dec. 15, 2014 The Defense ... it easier to detect and prevent counterfeit microcircuits ... Today the agency started performing an in-house microcircuit ... validate the authenticity of purchased microcircuits while increasing ... quality control measures will be conducted at DLA,s ...
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the ... than at international borders. Over the past decade, ... allowed veteran travelers to self process through border ... Kiosks at an increasing number of airports, seaports, ... According to Maxine Most , Principal ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... many cycles of global cooling and warming over the ... varied diet than they do today, according to a ... Institution paleontologists. The researchers, who analyzed California gray ... over the past 120,000 years, also found evidence to ...
... (July 6, 2011) The type of primary insurance ... the United States according to a study in the ... College of Surgeons. As a result, the type ... risk factor during preoperative risk stratification and planning, the ...
... Rochelle, NY, July 6, 2011A policy specialist and a ... $1.32 billion to bring a new drug to market ... Genetic Engineering & Biotechnology News (GEN). The researchers ... the numbers are subject to numerous internal and external ...
Cached Biology News:Gray whales likely survived the Ice Ages by changing their diets 2Gray whales likely survived the Ice Ages by changing their diets 3Gray whales likely survived the Ice Ages by changing their diets 4Gray whales likely survived the Ice Ages by changing their diets 5Outcomes for cardiac valve procedure patients are affected by insurance status 2GEN point of view article questions reported costs of drug R&D 2
... involves the optimization of immunostaining. ... of the primary antibody, selection ... (e.g. Alk. Phos., HRP, fluorescence, ... detection, evaluation by light or ...
... Quality ISO 9001:2000 Certified USDA Research ... Validated, SOP's Training AALAS Certified ... All Procedures GLP Documentation Upon Request ... shopping point for all your custom immunology ...
IC50: 190 pg/ml · Limit of detection: 60 pg/ml...
Request Info...
Biology Products: