Navigation Links
McLean Report on nanotechnology that may enhance medication delivery and improve MRI performance
Date:5/1/2012

adolinium contrast agents are often used to improve MRI performance. In one configuration, Vitaliano found that functionalized clathrin nanoparticles performed 8,000 times better than an FDA approved MRI contrast agent (gadopentetate dimeglumine).

"Stated another way, it means 8,000 times less gadolinium might be required for achieving good MRI results. Because very low gadolinium concentrations would be required for MRI, it could significantly decrease gadolinium toxicity, which is an important issue," explained Vitaliano. "Clathrin transported gadolinium is therefore among the most potent, biocompatible contrast agents available."

These results in two different applications showed that clathrin offers substantial functionalization and transport flexibility. Purified clathrin nanoparticles could therefore serve as an appealing alternative to other medical nanoplatforms such as dendrimers, nanogels, solid lipid nanospheres, liposomes, and the like.

Given the critical need for new types of CNS drug transport capabilities, Vitaliano said her work would likely be of interest to researchers involved in neuroimaging and neuroscience, but also to radiologists, bioengineers, chemists, physicists, material scientists, biomedical researchers, and other researchers active at the frontiers of imaging and drug delivery.

Looking ahead, Vitaliano noted that her findings may also facilitate other studies for examining signaling pathways in different diseases that rely in whole or in part on clathrin transport, and thus may have a substantial impact in multiple fields.


'/>"/>

Contact: Adriana Bobinchock
abobinchock@partners.org
617-855-2110
McLean Hospital
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Innophos Holdings, Inc. Reports First Quarter 2012 Results
2. 3SBio Inc. Files Annual Report on Form 20-F for Fiscal Year 2011
3. Cell Therapeutics, Inc. (CTI) Reports First Quarter Financial Results and Milestones
4. Cryo-Cell Reports Financial Results for First Quarter 2012
5. Vermillion Reports Fourth Quarter and Full Year 2011 Results
6. Soligenix Reports Year-End 2011 Financial Results and Highlights Recent Accomplishments
7. Xention Reports Positive Phase 1 Data for New Atrial Fibrillation Drug
8. GenVec Reports Fourth Quarter and 2011 Year-End Financial Results
9. Pharma IQs Compound Management Survey Report
10. EntreMed Reports Fourth Quarter and Year-End 2011 Financial Results
11. Phalanx Biotech Group Reports Robust Revenue Growth in 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... ... August 27, 2015 , ... Inc. Magazine released its annual list of the ... 1,361 in growth for the three years through 2014. Being named to the Inc. ... organizations in the country. , “We are thrilled to make the Inc. 5000 ...
(Date:8/27/2015)... RESEARCH TRIANGLE PARK, N.C. , Aug. 27, ... reports on the decision by FedEx, UPS and ... shipments of certain biological specimens classified as ,select ... expertise and long history of handling these sensitive ... network, knowledge of global transportation regulations, trained and ...
(Date:8/26/2015)... ... August 26, 2015 , ... ... that a second US laboratory is to open in Manhattan, Kansas in early ... partnership and long-term growth of research and development through collaboration with researchers from ...
(Date:8/26/2015)... -- Roka Bioscience, Inc. (NASDAQ: ROKA ), a molecular ... the detection of foodborne pathogens, today announced that Paul ... Company Emerging Growth Conference on September 2 at 9:20am ... York Marriott Marquis. A live webcast ... relations section of Roka Bioscience,s website at http://rokabio.investorroom.com/ ...
Breaking Biology Technology:iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3
... biotechnology,company developing clinical stage treatments for cancer and the ... CEO, is scheduled to present at the UBS Global ... The conference is being held at,the Grand Hyatt New ... BioVex is a privately held biotechnology Company based in ...
... is featured speaker: "Case Study - Screening Ion Channels ... Safety and Efficacy" on Friday, September 26 at 11:30, ... expanding,line of ion channel services and cell lines for ... and Cellular Targets,conference in San Diego, September 24-26. ChanTest ...
... BioTrends Research Group, Inc.,released its third annual ... providing insight into the management of,Rheumatoid Arthritis (RA), ... is based on responses to an online survey,completed ... According to the study, the majority of Rheumatologists ...
Cached Biology Technology:BioVex to Present at the UBS Global Life Sciences Conference 2ChanTest to Highlight the World's Largest Catalog of Ion Channel-Expressing Cell Lines and Discovery Services at Assays & Cellular Targets Conference, Booth 11 2Use of Biologic Agents Continues to Expand Among US Rheumatologists - Can New Agents Shift the Treatment Paradigm in Rheumatoid Arthritis? 2
(Date:7/31/2015)... julio de 2015 La 10 th International ... medio de BGI del 22 al 25 de octubre de 2015 ... Este año, la conferencia celebra su décimo aniversario. Desde su ... una de las reuniones anuales más influyentes del mundo en ... más dinámicas, entusiastas y mejores a nivel científico. ...
(Date:7/31/2015)... China , July 31, 2015 The 10 ... will be held by BGI from October 22-25, 2015, in ... The conference is celebrating its 10 th anniversary ... one of the world,s most influential annual meetings in the ... and enjoyable scientific gatherings. ICG-10 focuses on ...
(Date:7/27/2015)... ANGELES , July 27, 2015   ... evidence- and experience-based clinical improvement solutions, today announced ... solution is now available on Android smartphones and ... inpatient and post-care organizations can use ZynxCarebook to ... same patient,s condition, streamline care transitions to other ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3The 10th International Conference on Genomics (ICG-10) to Open in October 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3
... first workshop on male infertility in Thessaloniki, Greece "Reproductive ... workshop provides a forum for clinicians and scientists to ... Here some of the new research findings that fertility ... Nature versus Nurture: Male reproductive disorders ...
... State University is being honored for one of its ... K-State institute,s intern program has received the roundtable group,s ... MVP2 award, as the best pollution prevention project/program. The ... D.C. The award is presented based on a ...
... b3c newswire / - NiKem Research is pleased ... of Health, GLP certification of its bioanalysis facilities to further ... provided for many years high quality cost-effective bioanalytical support both ... in vivo PK services associated to various drug discovery ...
Cached Biology News:K-State Pollution Prevention Institute's intern program named best 2NiKem Research receives certification for GLP Bioanalysis 2
96 Well Plate UB, RE bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
96 Well Plate EB, RE bottom; high binding irradiated surface to provide increased binding affinity for hydrophilic proteins and complexes. Guaranteed coefficient of variation (CVs)....
Immulon 1 B 1x12 Strip, flat bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
...
Biology Products: