Navigation Links
Marriage of microfluidics and optics could advance lab-on-a-chip devices
Date:2/16/2010

tration, a 62 element zone-plate array measured a fluorescence signal from drops traveling down 62 channels of a highly parallel microfluidic device.

The device works by creating a focused excitation spot inside each channel in the array and then collects the resulting fluorescence emission from water drops traveling through the channels, literally taking stop-motion pictures of the drops as they pass.

"Water drops flow through each channel of the device at a rate of several thousand per second," explains lead author Ethan Schonbrun, a graduate student at SEAS. "Each channel is monitored by a single zone plate that both excites and collects fluorescence from the high speed drops. By using large arrays of microfluidic channels and zone plate lenses, we can speed up microfluidic measurements."

The series of images are then recorded by a digital semiconductor (CMOS) camera, allowing high speed observation of all the channels simultaneously. Moreover, the array is designed so that each zone plate collects fluorescence from a well-defined region of the channel, thereby avoiding cross talk between adjacent channels. The end result is a movie of the droplets dancing through the channels.

"Our approach allows us to make measurements over a comparatively large area over the chip. Most microscopes have a relatively limited view and cannot see how the whole system is working. With our device, we can place lenses wherever we want to make a measurement," adds Crozier.

The system can detect nearly 200,000 drops per second, or about four times the existing state-of-the-art detection systems. Further, the lens array is scalable, without any loss in efficiency, and can be peeled on-and-off like a reusable sticker. Ultimately, the integrated design offers the sensitivity of a larger confocal microscope and the ability to measure over a larger area, all in a much smaller, cheaper package.

"Because we have this massively paralle
'/>"/>

Contact: Michael Patrick Rutter
mrutter@seas.harvard.edu
617-496-3815
Harvard University
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Microfluidics Chairman James N. Little, Ph.D., Announces Retirement from Board of Directors
2. Microfluidics International Corporation Announces Third Quarter 2009 Financial Results
3. Microfluidics International Corporation to Report Third Quarter 2009 Financial Results on November 2, 2009
4. Microfluidics International Corporation Announces Second Quarter 2009 Financial Results
5. Microfluidics International Corporation to Report Second Quarter 2009 Financial Results on August 11, 2009
6. Particle Sciences and Microfluidics Collaborate to Share Formulation and Nanotechnology Expertise for Pharmaceutical Drug Product Development, Analysis and Commercialization
7. Nanopoint Applies CE Mark to Its cellTRAY(R) Imaging and Microfluidics Systems
8. Microfluidics Expands Distributorship in Japan with Exclusive POWREX Partnership to Meet Increased Demand in Pharmaceutical, Biotechnology and Energy Industries
9. GEN Reports on Growing Reliance on Microfluidics Technology
10. RainDance Technologies to Present Sequence Enrichment Using Droplet-Based Microfluidics Workshop at ASHG 2008
11. Optics made to measure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Marriage of microfluidics and optics could advance lab-on-a-chip devices
(Date:3/25/2015)... BLOOMINGTON, MN (PRWEB) March 25, 2015 ... a breakthrough in nanoparticle technology that will enable ... and many other diseases with a simple breath ... ahead on the U.S. Food and Drug Administration ... 2016 launch of the innovative Nanoparticle Biomarker Tagging ...
(Date:3/25/2015)... /CNW/ - The Gairdner Foundation is pleased to ... recognizing some of the most significant medical discoveries ... the world,s most esteemed medical research prizes, the ... a $100,000 (CDN) prize to each scientist for their work. ... and innovation across the country, inspiring the next ...
(Date:3/25/2015)... 2015 Proove Biosciences , a ... to announce the success of their commercially supported symposium, ... to Optimize the Management of Pain, at the 31st ... Harbor, Maryland on Thursday, March 19th, 2015. ... President Lynn Webster , M.D., former Florida Society ...
(Date:3/25/2015)... 25, 2015 Oxis International, Inc. (OXIS) (OXI.PA) ... commercialization, announced today Oxis CEO Tony Cataldo ... 2015 at 4:15pm EST to update shareholders and other ...     Oxis Chairman and CEO Tony ... been very exciting for Oxis and our shareholders. There ...
Breaking Biology Technology:Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 42015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 52015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 72015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 8Proove Biosciences Hosts Symposium on Incorporating Genetic Testing to Optimize the Management of Pain 2Oxis Biotech Inc. Announces Corporate Update Conference Call for March 31 2
... 7 Endocare, Inc. (Nasdaq: ENDO ) ... have entered into a settlement agreement stipulating to termination ... Galil Medical pursuant to which Endocare would have acquired ... in Delaware Chancery Court. , , ...
... Covance Inc. today ... company as vice president and chief scientific officer of ... industry experience, including bioanalytical research, translational research, and talent ... development strategy for Covance,s bioanalytical services. , ...
... advanced energy research , , MONTREAL, July 7 ... technology company, today announced that it will jointly form ... Edmonton and the Alberta Energy Research Institute (AERI). , ... demonstration of novel catalytic conversion processes to produce advanced ...
Cached Biology Technology:Endocare and Galil Medical Announce Settlement of Litigation 2Covance Appoints Dr. Steven M. Michael as Vice President and Chief Scientific Officer of Global Bioanalytical Services 2Enerkem Announces World-Class Advanced Energy Research Center in Edmonton, Alberta, Canada 2Enerkem Announces World-Class Advanced Energy Research Center in Edmonton, Alberta, Canada 3
(Date:3/12/2015)... Va. , March 12, 2015 IriTech, ... and a member of the Texas Instruments Design Network, ... Naidu has demonstrated its IriShield USB MK2120U device ... scanning facility for pension distribution. The ... assembled to be marketed in India ...
(Date:3/12/2015)... -- Beta Systems today announced Fast ... (IAM) solution for a fixed price and with ... IAM package, customers benefit from the 30 years, ... implementations across different industries. The new fixed-price IAM ... necessary services and consulting. It spans the implementation ...
(Date:3/11/2015)... DUBLIN , Mar. 11, 2015 Research and ... addition of the "Access Control Market by Product, ... to 2020" report to their offering. , ... is expected to reach $10.4 billion by 2020, with ... control market report covers the products types such as ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2
... December 1, 2008 Although naturally occurring smallpox was ... obtain smallpox from a laboratory and release it into ... vaccine may be insufficient for universal administration. In a ... The American Journal of Medicine , researchers found that ...
... induce major differentiations in the metabolic make-up of ... November 28 in the open-access journal PLoS ... led by Karsten Suhre, has conducted a genome-wide ... genes involved in the breakdown of fats. The ...
... through DNA but also through the millions of proteins and ... known as "epigenetic marks," act both as a switch and ... turned on or off, and how much message an "on" ... information is known to be passed from parent to offspring ...
Cached Biology News:New study indicates smallpox vaccination effective for decades 2Study identifies genetic variants giving rise to differences in metabolism 2CSHL scientists discover a new way in which epigenetic information is inherited 2CSHL scientists discover a new way in which epigenetic information is inherited 3
... to siRNA library screening, optimal ... identified and verified for each ... CellReady siRNA Transfection Optimization Kit, ... optimizing transfection conditions in 96 ...
... positioning slides offers multiple drive technologies ... and manual. With this series, users ... systems. These slides also offer anti-cage ... to 10 nanometers, integrated home/ limit ...
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
Kit Components: Anti-PARP LumiGLO Chemiluminescent Substrate Immunoblot Blocking Reagent Pyronin Y Reagent Goat Anti-Rabbit IgG, HRP conjugate Double-It Reagent Film Exposure Folders Autor...
Biology Products: