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March of Dimes Awards $250,000 Prize to Leaders in Understanding Embryonic Development
Date:5/5/2008

ons within the spinal cord.

Dr. Beachy is the Ernest and Amelia Gallo Professor in the Department of Developmental Biology and in the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University School of Medicine in Stanford, Calif. His research elucidated the processing and structure of the hedgehog protein signal and its attachment to cholesterol, and led to an understanding of malformations caused by deficiencies in hedgehog signaling, including brain and facial malformations associated with holoprosencephaly (when the brain fails to completely develop and divide). His work also produced important insights into the role and treatment of inappropriate hedgehog pathway activity in cancer.

Dr. Tabin is the George Jacob and Jacqueline Hazel Leder Professor and chair of the Department of Genetics at Harvard Medical School in Massachusetts. His research explains how anatomical form and organization emerge during the embryonic development of an organism, and how errors in this process lead to birth defects. His work with the Sonic hedgehog gene led to the first identification of genes differentially expressed on the left and right sides of the early embryo, a major breakthrough in understanding left-right asymmetry; as well as to an understanding of how bones muscles and tendons are placed in their proper orientation in the forming limbs.

The March of Dimes Prize in Developmental Biology has been awarded annually since 1996 to investigators whose research has profoundly advanced the science that underlies the understanding of birth defects. The March of Dimes Foundation created the Prize as a tribute to Dr. Jonas Salk, who received Foundation support for his work to create a polio vaccine.

Also on May 5, Dr. Beachy and Dr. Tabin will deliver the Thirteenth Annual March of Dimes Prize Lectures at the Hawaii Convention Center during the 2008 Annual Meeting of the Pediatric Academic Societies.

The March of D
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SOURCE March of Dimes
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