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MannKind Corporation Response to Recent Market Events
Date:3/10/2008

cursions,

approaching the levels seen in normal people, which are believed to be

an important risk factor in the development of complications from the

disease.

-- The ability to achieve comparable levels of overall glucose control

compared with present "state of the art" treatment, as measured by

HbA1c, which is considered the standard measure of a treatment's

effectiveness in diabetes.

-- A lower risk of hypoglycemia, which is considered to be a major problem

for patients using presently available insulins and many oral

treatments, limiting their ability to optimally treat their disease.

-- No weight gain and even weight loss in patients treated with

Technosphere(R) Insulin, in contrast to the weight gain that is usually

considered a major downside of insulin therapy for many patients.

-- No need for complex meal titration, as utilized in our studies to date,

significantly simplifying treatment and reducing the training typically

needed for insulin therapy.

-- No adverse effect on the measures of pulmonary function that have been

reported to occur with other inhaled insulins.

Even with these advantages over existing insulin therapy, MannKind understands that physicians and regulatory agencies are cautious about a new route of administration. For this reason, MannKind is conducting a very robust clinical trial program involving more than 5,000 patients with diabetes, which it determined is consistent with the FDA's recently released guidance for the development of drugs to treat diabetes. As part of this program, a 2,050-patient, two-year pulmonary safety trial will conclude later this year; this trial was recently recognized by the American Association of Respiratory Care as setting new quality standards in the conduct of clinical studies. In the interim, all of MannKind's clinical trials are monitored by an indep
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SOURCE MannKind Corporation
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