Navigation Links
Man-made pores mimic important features of natural pores
Date:7/17/2012

BUFFALO, N.Y. -- Inspired by nature, an international research team has created synthetic pores that mimic the activity of cellular ion channels, which play a vital role in human health by severely restricting the types of materials allowed to enter cells.

The pores the scientists built are permeable to potassium ions and water, but not to other ions such as sodium and lithium ions.

This kind of extreme selectivity, while prominent in nature, is unprecedented for a synthetic structure, said University at Buffalo chemistry professor Bing Gong, PhD, who led the study.

The project's success lays the foundation for an array of exciting new technologies. In the future, scientists could use such highly discerning pores to purify water, kill tumors, or otherwise treat disease by regulating the substances inside of cells.

"The idea for this research originated from the biological world, from our hope to mimic biological structures, and we were thrilled by the results," Gong said. "We have created the first quantitatively confirmed synthetic water channel. Few synthetic pores are so highly selective."

The research will appear July 17 in Nature Communications.

The study's lead authors are Xibin Zhou of Beijing Normal University; Guande Liu of Shanghai Jiao Tong University; Kazuhiro Yamato, postdoctoral scientist at UB; and Yi Shen of Shanghai Jiao Tong University and the Shanghai Institute of Applied Physics, Chinese Academy of Sciences. Other institutions that contributed to the work include the University of Nebraska-Lincoln and Argonne National Laboratory. Frank Bright, a SUNY Distinguished Professor of chemistry at UB, assisted with spectroscopic studies.

To create the synthetic pores, the researchers developed a method to force donut-shaped molecules called rigid macrocycles to pile on top of one another. The scientists then stitched these stacks of molecules together using hydrogen bonding. The resulting structure was a nanotube with a pore less than a nanometer in diameter.

"This nanotube can be viewed as a stack of many, many rings," said Xiao Cheng Zeng, University of Nebraska-Lincoln Ameritas University Professor of Chemistry, and one of the study's senior authors. "The rings come together through a process called self-assembly, and it's very precise. It's the first synthetic nanotube that has a very uniform diameter. It's actually a sub-nanometer tube. It's about 8.8 angstroms." (One angstrom is one-10th of a nanometer, which is one-billionth of a meter.)

The next step in the research is to tune the structure of the pores to allow different materials to selectively pass through, and to figure out what qualities govern the transport of materials through the pores, Gong said.


'/>"/>

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo
Source:Eurekalert  

Related biology technology :

1. BioNeutral Group Expands The Testing Of Its Ygiene Sterilant Against Anthrax Spores
2. University of Utah chemists use nanopores to detect DNA damage
3. Building Wireless Solution More Important than Ever with New Tablets
4. Carbon nanotubes can double growth of cell cultures important in industry
5. Spherix Announces Successful Completion of Important Toxicology Study of SPX-106
6. New method for producing precursor of neurons, bone and other important tissues from stem cells
7. Laboratory Equipment Marketplace LabX.com Receives Fresh Look and Updated Features
8. Tri-Valley Dentist Dr. Endre Selmeczy Currently Features Oral Sedation Dentistry
9. Eppendorf Video Features Dr Andrew Holts Work on Bioactive Leachates From Plastic Consumables
10. In Comes the Non-Toxic Rust Remover; Rusterizer Presents Its Rust Removal Product Made With Natural Ingredients
11. Evolution Issue of the Month 2. Natural Selection--Not the Best Idea Anyone Ever Had
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Man-made pores mimic important features of natural pores
(Date:10/12/2017)... ... October 12, 2017 , ... ... multicenter, prospective clinical study that demonstrates the accuracy of the FebriDx® test, ... clinically significant acute bacterial and viral respiratory tract infections by testing the ...
(Date:10/11/2017)... ... 2017 , ... At its national board meeting in North ... the co-founder, CEO and chief research scientist of Minnesota-based Advanced Space Technology and ... ARCS Alumni Hall of Fame . ASTER Labs is a technology development ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., ... a Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. ... best practices and how Proscia improves lab economics and realizes an increase in ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/30/2017)... March 30, 2017 Trends, opportunities and forecast ... behavioral), by technology (fingerprint, AFIS, iris recognition, facial recognition, ... others), by end use industry (government and law enforcement, ... and banking, and others), and by region ( ... Asia Pacific , and the Rest ...
(Date:3/27/2017)... N.Y. , March 27, 2017  Catholic ... Information and Management Systems Society (HIMSS) Analytics for ... EMR Adoption Model sm . In addition, CHS ... of U.S. hospitals using an electronic medical record ... for its high level of EMR usage in ...
Breaking Biology News(10 mins):