Navigation Links
Malaria parasite caught red-handed invading blood cells
Date:1/19/2011

es unfolding at nanometer scales. The team worked closely with Associate Professor Cynthia Whitchurch and Dr Lynne Turnbull from the i3 institute at UTS to capture these images.

"This is just the beginning of an exciting new era of discoveries enabled by this technology that will lead to a better understanding of how microbes such as malaria, bacteria and viruses cause infectious disease," Associate Professor Whitchurch said.

Dr Baum said the methodology would be integral to the development of new malaria drugs and vaccines. "If, for example, you wanted to test a particular drug or vaccine, or investigate how a particular human antibody works to protect you from malaria, this imaging approach now gives us a window to see the actual effects that each reagent or antibody has on the precise steps of invasion," he said.

Malaria is caused by the Plasmodium parasite, which is transmitted by the bite of infected mosquitoes. Each year more than 400 million people contract malaria, and as many as a million, mostly children, die.

"Historically it has been very difficult to both isolate live and viable parasites for infection of red blood cells and to employ imaging technologies sensitive enough to capture snapshots of the invasion process with these parasites, which are only one micron (one millionth of a metre) in diameter," Dr Baum said.

He said one of the most interesting discoveries the imaging approach revealed was that once the parasite has attached to the red blood cell and formed a tight bond with the cell, a master switch for invasion is initiated and invasion will continue unabated without any further checkpoints.

"The parasite actually inserts its own window into the cell, which it then opens and uses to walk into the cell, which is quite extraordinary," Dr Baum said. "Visually tracking the invasion of Plasmodium falciparum into a red blood cell is something I've been aiming at ever since I began at
'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-417-125-700
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Advanced Life Sciences Announces US Army Collaboration to Research and Develop Restanza for the Treatment of Malaria
2. The first malaria-proof mosquito
3. Advanced Life Sciences Announces Restanza(TM) Shows Efficacy Against Malaria
4. Sanaria Inc. Receives Multi-Year U.S. NIH Phase II Small Business Innovation Research Grant to Develop a Genetically Attenuated Whole Parasite Malaria Vaccine
5. Scientists transplant nose of mosquito, advance fight against malaria
6. Discovery provides new drug targets for malaria cure
7. First genetically engineered malaria vaccine to enter human trials
8. GenVec Expands Contract Supporting Malaria Vaccine Program
9. Fincor (FINC) Makes a Share Transfer and Enters the Market With ACTRx a New Malaria and Dengue Fever Treatment
10. Chimerix Joins International Network of Organizations to Cure Malaria
11. ImmunoVaccine Technologies Signs Agreement with National Institutes of Health to Explore Vaccines for HIV and Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Malaria parasite caught red-handed invading blood cells
(Date:12/24/2014)... 2014 Earlier this year in a ... director of the Adult Stem Cell Technology Center, LLC ... and under appreciated unique property of adult tissue stem ... Cells: Misunderstood in the Past, Important for the Future,” ... He gave the address at the 4th World ...
(Date:12/24/2014)... 23, 2014 The report ... as its definition, classification, application and industry ... manufacturing process, and product cost structure. Production ... The analysis also covers upstream raw materials, ... development trend and proposals. In the end, ...
(Date:12/24/2014)... , Dec. 23, 2014 China ... the "Company"), a leading fully integrated plasma-based biopharmaceutical ... announced that its majority-owned subsidiary, Shandong Taibang Biological ... ("GMP") certification from the China Food and Drug ... production facility. As previously disclosed in the Company,s ...
(Date:12/24/2014)... 2014  Rock Creek Pharmaceuticals, Inc., (NASDAQ: ... Clinical Trial Application (CTA) with the United ... seeking regulatory approval to initiate clinical trials for the ... Contingent on the Company receiving CTA regulatory approval, ... to assess the safety, tolerability and dose escalation of ...
Breaking Biology Technology:Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3
... Gene arrays are solid supports upon which a , ... have been placed at , ... array analysis, a nucleic acid-containing sample is labeled , ... on the array. (In the literature, the term ...
... Ambion has developed a system for , ... on in vitro , transcription, ... (patent pending). This kit produces transfection-ready siRNA , ... researchers at the Salk Institute describe the successful , ...
... The Silencer siRNA , ... column purification to prepare transfection-ready siRNAs. With , ... is one example of how siRNAs prepared by the , ... in gene silencing studies. , ...
Cached Biology Technology:Array Analysis: The Basics 2Array Analysis: The Basics 3Array Analysis: The Basics 4Array Analysis: The Basics 5Your Data: Silencing Neural Cell Adhesion Genes with In Vitro Transcribed siRNAs 2Your Data: Silencing Hepatitis C Virus Replication With In Vitro Transcribed siRNAs 2
(Date:12/10/2014)... 2014 You,ve been here before: you desperately need ... your password, site key or the answer to your secret ... teacher? Today, Hoyos Labs , a ... will finally put an end to the frustration that comes ... . 1U leverages a user,s smartphone to acquire his or ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Wake Forest Baptist ... education building for its School of Medicine. Funding for ... larger capital campaign that will be publicly launched next ... be located in the former 60 series R.J. Reynolds ... Innovation Quarter. Construction will begin immediately with plans to ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and ... the addition of the "Biometrics Market in ... http://photos.prnewswire.com/prnh/20130307/600769 ... projects such as rural banking and upgradation of ... trends witnessed in the market. Besides the aforementioned ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... This release is available in German . ... and know-how in micro- and nanotechnologies for users from ... by KIT is starting operation: Ten leading institutions from ... available a total of 36 high-tech installations along with ...
... most invasive plants introduced to the U.S. from Europe and ... the natives. A new study indicates that eventually, however, its ... becomes less potent. The study, in Proceedings ... the first to show that evolutionary forces can alter the ...
... Institute at Oregon State University suggests that some natural food ... prevent cancer, may be able to play a more significant ... drugs that are now used in chemotherapy. A new ... examined the activity of chlorophyllin and found that, on ...
Cached Biology News:Scientific pathways into the nanoworld 2Scientific pathways into the nanoworld 3Over time, an invasive plant loses its toxic edge 2Over time, an invasive plant loses its toxic edge 3Natural compounds, chemotherapeutic drugs may become partners in cancer therapy 2Natural compounds, chemotherapeutic drugs may become partners in cancer therapy 3