Navigation Links
Malaria discovery gives hope for new drugs and vaccines
Date:9/1/2011

An investigation into the mysterious inner workings of the malaria parasite has revealed that it survives and proliferates in the human bloodstream thanks in part to a single, crucial chemical that the parasite produces internally.

According to scientists at the University of California, San Francisco (UCSF) and Stanford Medical School, reporting today in the journal PLoS Biology, this insight immediately provides a powerful new tool for discovering and designing drugs to treat malaria, which infects hundreds of millions of people around the world each year and claims about a million lives mostly children.

The work also gives researchers a hypothetical new vaccine to test: a weakened version of the parasite, which the scientists grew in the test tube by supplying it with the chemical it needed to live while at the same time treating it with drugs to eliminate its ability to produce that chemical on its own.

"It's as if we designed a ticking time bomb inside the parasite that's ready to go off and when it does, the parasite dies," said Joseph DeRisi, PhD, a Howard Hughes Investigator at UCSF and vice-chair of the Department of Biochemistry and Biophysics, who led the work.

In theory, health officials could inoculate people living in areas where malaria is common with a similar "attenuated" form of the parasite. If it works, the modified parasite would not make those people sick but would give them resistance to the pathogen if they were later exposed to it although that approach would need to be tested in clinical trials to determine whether it would work.

"It is an intriguing possibility that must be explored," said Ellen Yeh, MD, PhD, the co-author of the study. Yeh is a postdoctoral researcher at UCSF and also on the faculty of the Pathology Department at Stanford University.

Slow, Brutish and Incomplete: A Short History of Malaria Control

Few diseases in history have been as
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-4608
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology technology :

1. Malaria Parasite and Mosquito Products and Assay Services Available for Sale by Sanaria
2. New Biomarkers Study Could Lead to Better Malaria Vaccine Design
3. Malaria parasite caught red-handed invading blood cells
4. Advanced Life Sciences Announces US Army Collaboration to Research and Develop Restanza for the Treatment of Malaria
5. The first malaria-proof mosquito
6. Advanced Life Sciences Announces Restanza(TM) Shows Efficacy Against Malaria
7. Sanaria Inc. Receives Multi-Year U.S. NIH Phase II Small Business Innovation Research Grant to Develop a Genetically Attenuated Whole Parasite Malaria Vaccine
8. Scientists transplant nose of mosquito, advance fight against malaria
9. Discovery provides new drug targets for malaria cure
10. First genetically engineered malaria vaccine to enter human trials
11. GenVec Expands Contract Supporting Malaria Vaccine Program
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Malaria discovery gives hope for new drugs and vaccines
(Date:9/19/2014)... Barnhardt Manufacturing Company has earned ... Organic Cotton . The USDA Certified Biobased Product Label ... meets or exceeds levels set by USDA. Biobased products ... in significant part of agricultural, forestry, or marine ingredients. ... to be immediately identified as a USDA certified BioPreferred ...
(Date:9/18/2014)... Bipartisan passage this week by the ... stimulate development and commercialization of new technologies and promote ... of SPIE, the international society for optics and ... Innovation (RAMI) Act, now moves to the full Senate ... are optimistic that it will win passage there as ...
(Date:9/18/2014)...  Health Enhancement Products, Inc. (OTCQB: HEPI), a ... and metabolic processes, is pleased to announce the addition of ... Nola E. Masterson , a California ... September 17, 2014. "We,re very pleased and ... states Andrew Dahl , President and CEO. "She joins ...
(Date:9/18/2014)... -- Research and Markets has announced ... Report 2014" report to their offering. ... is a professional and in-depth study on the ... The report provides a basic overview of ... chain structure. The N-acetylcysteine market analysis is provided ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Global N-acetylcysteine Industry Report 2014 2
... LIBREVILLE, Gabon, December 2 ... Africa: Everyone,s Problem and Heritage" , ... June 2010 the,Gabonese Republic is hosting an international conference ... in Africa. The,conference will be attended by government and ...
... , ... an event bringing together the leaders in technology development ... announced the December 11th deadline for technology abstracts and ... World, in association with the Nano Science and Technology ...
... , SINGAPORE, Dec. 2 S*BIO Pte Ltd today ... at The American Society of Hematology 51st Annual Meeting and ... the clinical results from the Phase 1 dose-escalation trial of ... dose levels ranging from 100 to 600 mg. These doses ...
Cached Biology Technology:Libreville International Conference 2-3 June 2010 2Deadline Approaching for Largest Commercialization Event for Nanotech & Clean Technologies 2Deadline Approaching for Largest Commercialization Event for Nanotech & Clean Technologies 3S*BIO Novel Oral JAK2 Inhibitor SB1518 Demonstrates Safety and Tolerability in Phase 1 Studies for the Treatment of Myeloproliferative and Other Hematological Disorders 2S*BIO Novel Oral JAK2 Inhibitor SB1518 Demonstrates Safety and Tolerability in Phase 1 Studies for the Treatment of Myeloproliferative and Other Hematological Disorders 3S*BIO Novel Oral JAK2 Inhibitor SB1518 Demonstrates Safety and Tolerability in Phase 1 Studies for the Treatment of Myeloproliferative and Other Hematological Disorders 4S*BIO Novel Oral JAK2 Inhibitor SB1518 Demonstrates Safety and Tolerability in Phase 1 Studies for the Treatment of Myeloproliferative and Other Hematological Disorders 5
(Date:9/18/2014)... tonight at the third annual Golden Goose Award ceremony ... infants and in paving the way for the telecommunications ... by the National Science Foundation, the National Institutes of ... honored at a ceremony at the Library of Congress ... Congress will be on hand to help present their ...
(Date:9/18/2014)... are too stressed they are often grouchy, grumpy, nasty, ... (BMI) at EPFL have just highlighted a fundamental synaptic ... the loss of social skills and cognitive impairment. When ... molecule in the brain. This was revealed by a ... Carmen Sandi,s team went to look for answers in ...
(Date:9/18/2014)... their entire lives nestling in the protective tentacles of ... they sometimes travel hundreds of kilometres across the open ... fish has been predicted, this is the first time ... populations has been observed. , Dr Steve Simpson, Senior ... University of Exeter, and colleagues from the Australian Research ...
Breaking Biology News(10 mins):3rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2How stress tears us apart 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3
... the human gut adaptively shifts more than a quarter ... diet changes from sugar to complex carbohydrates. , This ... survive rapidly changing nutrient conditions but also helps maintain ... microbial society, according to researchers at Washington University School ...
... Inc. (Nasdaq: NGEN), developer of advanced diagnostic products, announced ... "Multiplexed Active Biologic Array" by the U.S. Patent and ... of addressing one or more electrodes (or "test sites") ... patent also covers a method for storing the value ...
... owners because of their vibrant colors. But those colors may ... For more than a century, biochemists have known that parrots ... of plumage colors, but their biochemical identity has remained elusive. ... behind the colors of parrots, describing on a molecular level ...
Cached Biology News:Highly adaptable genome in gut bacterium key to intestinal health 2Highly adaptable genome in gut bacterium key to intestinal health 3Nanogen Issued Patent for Electronic Microarray With Memory 2Transport System Smuggles Medicines Into Brain 2Transport System Smuggles Medicines Into Brain 3
... Odyssey images are easily imported for data analysis , ... ... Extensive background and signal options to optimize, ... results , ...
... UltraPure Agarose and SYBR Safe DNA Gel Stain ... Saves money versus buying these same products separately ... alternative to ethidium bromide ... Agarose resolves DNA and RNA fragments from 100 bp ...
... E.Coli glycerol stocks contained in standard 96-well ... clones with approximately 5,000 clones per plate. ... plate well, the corresponding subplate is screened ... the positive well(s). Cells from a positive ...
... ml per liter of urine will give a ... BMD dipstick. ,Certification: The Donors are of ... to be NEGATIVE for HbsAg, HCV, HIV-1 & ... FDA methods. THIS MATERIAL IS SOLD FOR IN-VITRO ...
Biology Products: