Navigation Links
Making bacteria make useful proteins
Date:9/6/2009

By adapting a single protein on the surface of the bacterium Caulobacter crescentus, researchers at the University of British Columbia have turned it into a protein production factory, making useful proteins that can act as vaccines and drugs. Dr. John Smit presented the findings at the Society for General Microbiology's meeting at Heriot-Watt University, Edinburgh, today (7 September).

C. crescentus is a harmless bacterium that has a single protein layer on its surface. Dr Smit's team adapted the system that secretes this protein, which self-assembles into a structure called the "S-layer", to secrete instead many proteins that are useful for vaccines and other therapeutic purposes. Or, by keeping the S-layer protein intact and genetically inserting new things inside it, they produce a very dense display of useful proteins on the cell surface and then expect to use the entire bacterium in a therapeutic application.

Bacteria are commonly used in biotechnology to produce useful protein products. If the bacteria secrete the protein rather than keep it contained within the cell, purification costs are greatly lowered. The researchers have developed a commercially available kit based on this technology, which could be especially useful in developing countries as it might be used to manufacture HIV-blocking agents very cheaply and with little specialist expertise.

"This S-layer system is very efficient at producing and secreting proteins we can make the bacterium into a protein pump, secreting over half of all the protein it makes as engineered S-layer protein," said Dr Smit, "Applications of S-layer display that we are currently developing include anti-cancer vaccines, an HIV infection blocker and agents to treat Crohn's and colitis, and diarrhoea in malnourished populations".


'/>"/>

Contact: Dianne Stilwell
diannestilwell@me.com
44-795-720-0214
Society for General Microbiology
Source:Eurekalert

Page: 1

Related biology technology :

1. Analysis of Biofuels Indirect Land Use Effects Finds the Science Lacking: Too Diffuse and Subject To Too Many Arbitrary Assumptions To Be Useful for Rule-making.
2. Bioterrorism and disaster preparedness explored in special issue of Medical Decision Making
3. Brain research shows past experience is invaluable for complex decision making
4. Global Financial Crisis Making Biotech Business Model Unsustainable, According to Ernst & Young
5. Physicists discover important step for making light crystals
6. Patent for Making Combination Chemotherapy Work Better
7. Nanonet circuits closer to making flexible electronics reality
8. Controlling the size of nanoclusters: First step in making new catalysts
9. Making a good impression: Nanoimprint lithography tests at NIST
10. Carrington Subsidiary DelSite Starts Making Test Batches of First Bird Flu Vaccine Offering Needle-free Self-Administration
11. DuPont Chief Science & Technology Officer Offers Perspectives on Science and Global Policymaking at Davos World Economic Forum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/11/2017)... ... October 11, 2017 , ... ... today it will be hosting a Webinar titled, “Pathology is going digital. Is ... , on digital pathology adoption best practices and how Proscia improves lab economics ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today ... designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) ... able to cross the cell membrane and bind intracellular STAT3 and inhibit its ...
(Date:10/10/2017)... Parks Associates announced today that Tom Kerber , Director ... , October 11 in Scottsdale, Arizona . Kerber will ... safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the introduction of ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series will feature ... Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ... how to continue to feed a growing nation. At the same time, many of ...
Breaking Biology Technology:
(Date:3/30/2017)... , March 30, 2017 The research team ... for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint ... new realm of speed and accuracy for use in identification, crime ... affordable cost. ... A ...
(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
(Date:3/27/2017)... ROCKVILLE CENTRE, N.Y. , March 27, 2017 ... by Healthcare Information and Management Systems Society (HIMSS) ... Analytics Outpatient EMR Adoption Model sm . In ... top 12% of U.S. hospitals using an electronic ... recognized CHS for its high level of EMR ...
Breaking Biology News(10 mins):