Navigation Links
Major disease-vector mosquito reveals the secrets of its immune system
Date:10/1/2010

1st October 2010 - The Culex quinquefasciatus mosquito poses a significant threat to human health as a blood-sucking transmitter of elephantiasis-causing worms and encephalitis-inducing viruses. An international team of scientists, including researchers from the University of Geneva and the SIB Swiss Institute of Bioinformatics sequenced its genome and studied its responses to pathogen infections. Two articles published in today's issue of Science, describe results from comparing the Culex mosquito with the malaria mosquito, Anopheles gambiae, and the dengue mosquito, Aedes aegypti, which offer new insights into the elimination of insect-transmitted diseases that seriously impact on global public health.

Mosquitoes are the most important disease-vectors. Species of Culex, Aedes, and Anopheles mosquitoes are responsible for the transmission of many human pathogens including parasites that cause malaria, viruses that trigger dengue and yellow fever, and West Nile encephalitis, as well as worms that cause lymphatic filariasis (also called elephantiasis). The capacity of different mosquito species to transmit these and other pathogens varies greatly, and much of this variation can be attributed to the mosquito immune system's ability to recognise and eliminate the pathogen. Applying their expertise in comparative evolutionary genomic analyses and insect immunity, Professor Evgeny Zdobnov and Dr Robert Waterhouse, from the University of Geneva Medical School and the SIB Swiss Institute of Bioinformatics, joined forces with scientists from around the world to examine the Culex genome and its encoded genes.

Sequencing of the Culex genome, directed by Peter Atkinson and Peter Arensburger from the University of California Riverside, allowed researchers to perform a thorough comparison among the three disease-vector mosquito species. Focusing on the mosquito immune system, researchers led by Professor Marc Muskavitch from Boston College, the Broad Institute, and Harvard School of Public Health, examined the responses of each mosquito species to different pathogens including parasites, viruses, bacteria, and worms, to identify genes that play a role in mosquito immune defences."Our pathogenomics study took advantage of the sequencing of the Culex quinquefasciatus genome" says Professor Muskavitch, "to bring together data from experiments profiling responses of mosquito genes to pathogen infections, directed by Professor Lyric Bartholomay, with the results of comparative immunogenomics analyses led by Dr Robert Waterhouse". This study revealed many differences among these three mosquito species, and also that Culex, the most geographically widespread, "has an expanded immune gene repertoire, which may enhance its ability to adapt to diverse habitats with different pathogen challenges", explains Dr Waterhouse.

"These important studies" says Professor Zdobnov, "highlight how genome sequencing can greatly facilitate detailed experimental investigations to uncover the complex biology of these major disease-vector mosquitoes". Professor Bartholomay, from Iowa State University, adds that "by comparing numerous combinations of mosquito species infected with different pathogen types, our results indicate that pathogens that successfully develop in, and are transmitted by, disease-vector mosquitoes, have evolved to avoid mosquito immune responses". Improving our understanding of these vector-pathogen relationships significantly advances the long-term objectives of developing strategies to reinforce the mosquitoes' defences, making them immune to infections and breaking the chain of pathogen transmission.


'/>"/>

Contact: Irene Perovsek
irene.perovsek@isb-sib.ch
41-216-924-050
Swiss Institute of Bioinoformatics
Source:Eurekalert

Related biology technology :

1. deCODE Discovers Major Genetic Risk Factor for the Most Common Form of Glaucoma
2. All-New Sermo Brings Major Enhancements to Nations Largest Online Physician Community
3. deCODE Discovers Genetic Risk Factor Linking Susceptibility to Four Major Vascular Diseases
4. Iowa Gains Momentum as Major Provider of Biorenewables
5. Orexigen(R) Therapeutics Announces That Contrave(R) Reduced Depression Scores and Body Weight in Overweight and Obese Patients With Major Depression
6. University of Minnesota researchers clear major hurdle in road to high-efficiency solar cells
7. Lexicon to Present at Two Major Healthcare Investor Conferences
8. Sensient Technologies Corporation Announces Major Investment in Natural Colors
9. Encorium Group, Inc. Announces New Business Contract Wins of $6.8 Million, Including Two Pivotal Phase III Studies for a Major Asian Technology Company
10. Epeius Biotechnologies Reports Major Clinical Advances: Noteworthy Clinical Case Studies in Cancer Gene Therapy
11. Graphene films clear major fabrication hurdle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
(Date:6/23/2016)... YORK , June, 23, 2016  The Biodesign ... to envision new ways to harness living systems and ... Modern Art (MoMA) in New York City ... than 130 participating students, showcased projects at MoMA,s Celeste ... Paola Antonelli , MoMA,s senior curator of architecture ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... announced the launch of the Supplyframe Design Lab . Located in Pasadena, ... explore the future of how hardware projects are designed, built and brought to ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published today ... a patient who developed lymphedema after being treated for breast cancer benefitted from an ... paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
Breaking Biology Technology:
(Date:6/27/2016)... , June 27, 2016 Research and Markets ... America 2016-2020" report to their offering. ... North America to grow at a CAGR of 12.28% ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
(Date:6/22/2016)... American College of Medical Genetics and Genomics was once again ... of the fastest-growing trade shows during the Fastest 50 Awards ... Las Vegas . Winners are ... of the following categories: net square feet of paid exhibit ... 2015 ACMG Annual Meeting was ranked 23 out of 50 ...
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
Breaking Biology News(10 mins):