Navigation Links
MacroGenics Receives NIH Grant Funding of $9.8M for Three Projects; Funding Further Advances DART Platform and Infectious Disease Portfolio
Date:7/15/2010

ue of Arthritis & Rheumatism(1) and the June 2010 issue of Journal of Molecular Biology(2).  In addition, progress with respect to the company's DART platform has been presented at several recent scientific conferences.

This platform has broad potential applications for developing novel therapeutics.  These include approaches to signaling immune-mediated cells to treat autoimmune disorders, the redirecting of immune cells to kill tumors and inhibition of different signaling pathways required for tumor growth.  Furthermore, this technology is especially promising for treating certain infectious diseases, as it enables the targeting of two serotypes of a pathogen with a single molecule.

"We have made tremendous progress on our DART platform," said Dr. Scott Koenig, President and CEO.  "We believe we have the ability to create highly potent DART-based therapeutics and the funding from NIH will help us move forward two product candidates based on our proprietary platform."

Background on DART

MacroGenics' DART technology is focused on dual specificity antibody-based therapeutic proteins, which enables the creation of highly stable, recombinant molecules that can simultaneously target two different antigens. DART therapeutics can accommodate virtually any variable region sequence in a "plug-and-play" fashion, are potent, and have very favorable manufacturing properties.  To date, the company has engineered over 60 different DART molecules and has completed multiple in vitro and in vivo proof-of-concept studies with several prototypes.  The company has been able to produce DART molecules in both bacterial and mammalian expression systems. DARTs also have been engineered with an Fc domain, which confers them with additional pr
'/>"/>

SOURCE MacroGenics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. MacroGenics Raises $25M in Series D-2 Financing
2. MacroGenics Appoints New Vice President of Business Development
3. Paulo F. Costa Joins MacroGenics Board of Directors
4. MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus
5. Medicsight Receives Brazilian State Food and Drug Administration Approval for ColonCAD Software
6. Angiotech receives CE Mark approval of HemoStream(TM) Chronic Dialysis Catheter
7. SGX - Lilly Merger Offer Receives Positive Opinions From Proxy Advisory Firms
8. CV Therapeutics Receives European Approval for the Brand Name Ranexa(R)
9. XTL Biopharmaceuticals Receives Notice of Non-Compliance with Nasdaq Marketplace Rule Due to Changes in Board Composition
10. BMP Sunstone Receives Production License from the SFDA to Manufacture and Market Pediatric Multivitamin Granules in the PRC
11. Biotest Diagnostics Receives FDA Clearance for Full Line of Traditional Blood Bank Reagents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2015)... DUBLIN , July 29, 2015 ... ) has announced the addition of the ... to their offering. The Global Biosimilars ... study of the rapidly growing biosimilars market. With ... industry striving to minimize costs, biosimilars are being ...
(Date:7/29/2015)... DIEGO , July 29, 2015  Pfenex Inc. ... 2015 financial results will be released on Thursday, August ... am Eastern Time, Pfenex management will host a conference ... business update.  A press release outlining the financial results ... the call. Please call 1-866-376-8058 (US) or ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - Aeterna Zentaris Inc. ... it has selected an optimized Erk inhibitor molecule ... the development of a new class of potential ... represents a prime target for therapeutic intervention in ... and survival benefits for B-Raf and Mek inhibitors. ...
(Date:7/29/2015)... ... ... Costello served as Lead Levee Design Engineering Manager for a feasibility study of ... future storm surge flooding, such as occurred in Hurricane Ike in 2008. , ... protection, Costello also balanced socio-economic and environmental needs and concerns. The team ...
Breaking Biology Technology:Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 3Preventing Storm Surge Flooding in Houston 2
... for highly specific digestion of purified,proteins or proteins ... Johanna Claycomb * ChaoFeng Zheng * Denise Wyborski,* ... A.K. Bernardino * Peter Vaillancourt ,Stratagene Cloning Systems, ... sitespecific,protease that cleaves at the carboxy terminus of ...
... system provides quality images from,nanogram quantities of RNA , ... ,Stratagene , The SYBR Gold ... II still,video system, allows the integrity of only ... , In Stratagenes Custom Library Department, we often construct cDNA,libraries ...
... TaqPlus Long DNA polymerase to genotype,mice ... ,Cardiovascular Research Center, University of Cincinnati, Cincinnati, OH , ... using,long-distance PCR, whereby genomic DNA is isolated from mouse ... Long DNA,polymerase.* , , PCR is ...
Cached Biology Technology:Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini 2Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini 3Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini 4Improved Sensitivity for Staining RNA with SYBR Gold Stain 2Improved Sensitivity for Staining RNA with SYBR Gold Stain 3Easily Amplify Genomic DNA with Long-Distance PCR 2Easily Amplify Genomic DNA with Long-Distance PCR 3Easily Amplify Genomic DNA with Long-Distance PCR 4Easily Amplify Genomic DNA with Long-Distance PCR 5Easily Amplify Genomic DNA with Long-Distance PCR 6Easily Amplify Genomic DNA with Long-Distance PCR 7
(Date:7/23/2015)... DUBLIN , July 23, 2015 ... the addition of the "Global Outlook of ... their offering. The global biometrics ... both public and commercial applications owing to the ... will witness a transformation that enhances the growth ...
(Date:7/20/2015)... 20, 2015  Acuity Market Intelligence,s latest research ... of Commerce and Privacy" forecasts that between 2014 ... will be downloaded to smart mobile devices by ... market is projected to generate more than $67.9 ... seven-year forecast period.    "Biometrics is ...
(Date:7/9/2015)... July 07, 2015 ... addition of the "Biometrics for Banking; Market ... report to their offering. The ... to this growth and the forecast is that ... revenue for companies involved in delivering biometric systems ...
Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
... and Increases EfficiencyWALL, N.J., May 19 ... a leader in finger-based biometric identification and ... Minnesota counties are deploying BIO-key,s WEB-key(R) biometric ... paperless criminal charging, or eCharging system.(Logo: ...
... have identified two new genes and two new enzymes in ... plants were making monoterpenes, compounds that help give tomato leaves ... face of accepted thought. Such research could help researchers ... on years of research, scientists thought that plants always used ...
... Texas, more than two million homes were without power, ... looking for ways to entertain children, a move that ... The University of Texas Health Science Center at Houston ... monoxide poisoning caused by gasoline-powered electrical generators were playing ...
Cached Biology News:Minnesota Counties Secure New Criminal Charging System With BIO-key(R) Fingerprint Biometrics 2Minnesota Counties Secure New Criminal Charging System With BIO-key(R) Fingerprint Biometrics 3MSU discoveries upend traditional thinking about how plants make certain compounds 2Pediatric carbon monoxide poisoning linked to video games after Hurricane Ike 2
Homo sapiens jumping translocation breakpoint...
One-step, microplate or cuvet, colorimetric 530nm, detection limit 0.16mg/dL in serum or plasma. Procedure: 10 min....
MOUSE ANTI HUMAN NPM...
Edited by D. Rickwood, T.C. Ford and J.T. Steensgaard (1994) Compiles core data required by researchers carrying out any centrifugal separation, whether working with cells, organelles or macromolec...
Biology Products: