Navigation Links
MacroGenics Receives NIH Grant Funding of $9.8M for Three Projects; Funding Further Advances DART Platform and Infectious Disease Portfolio
Date:7/15/2010

ue of Arthritis & Rheumatism(1) and the June 2010 issue of Journal of Molecular Biology(2).  In addition, progress with respect to the company's DART platform has been presented at several recent scientific conferences.

This platform has broad potential applications for developing novel therapeutics.  These include approaches to signaling immune-mediated cells to treat autoimmune disorders, the redirecting of immune cells to kill tumors and inhibition of different signaling pathways required for tumor growth.  Furthermore, this technology is especially promising for treating certain infectious diseases, as it enables the targeting of two serotypes of a pathogen with a single molecule.

"We have made tremendous progress on our DART platform," said Dr. Scott Koenig, President and CEO.  "We believe we have the ability to create highly potent DART-based therapeutics and the funding from NIH will help us move forward two product candidates based on our proprietary platform."

Background on DART

MacroGenics' DART technology is focused on dual specificity antibody-based therapeutic proteins, which enables the creation of highly stable, recombinant molecules that can simultaneously target two different antigens. DART therapeutics can accommodate virtually any variable region sequence in a "plug-and-play" fashion, are potent, and have very favorable manufacturing properties.  To date, the company has engineered over 60 different DART molecules and has completed multiple in vitro and in vivo proof-of-concept studies with several prototypes.  The company has been able to produce DART molecules in both bacterial and mammalian expression systems. DARTs also have been engineered with an Fc domain, which confers them with additional pr
'/>"/>

SOURCE MacroGenics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. MacroGenics Raises $25M in Series D-2 Financing
2. MacroGenics Appoints New Vice President of Business Development
3. Paulo F. Costa Joins MacroGenics Board of Directors
4. MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus
5. Medicsight Receives Brazilian State Food and Drug Administration Approval for ColonCAD Software
6. Angiotech receives CE Mark approval of HemoStream(TM) Chronic Dialysis Catheter
7. SGX - Lilly Merger Offer Receives Positive Opinions From Proxy Advisory Firms
8. CV Therapeutics Receives European Approval for the Brand Name Ranexa(R)
9. XTL Biopharmaceuticals Receives Notice of Non-Compliance with Nasdaq Marketplace Rule Due to Changes in Board Composition
10. BMP Sunstone Receives Production License from the SFDA to Manufacture and Market Pediatric Multivitamin Granules in the PRC
11. Biotest Diagnostics Receives FDA Clearance for Full Line of Traditional Blood Bank Reagents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... May 22 Amsterdam,Molecular Therapeutics (Euronext: AMT), ... gene,therapy, today announced that it obtained a ... to their advanced small nuclear RNA,(snRNA)-based exon-skipping ... (DMD). The combination with AMT,s proprietary,adeno-associated virus ...
... you, but to Hemant Jain they are the first steps ... the University of WisconsinMilwaukees Kenilworth Square Apartments, the appliances operate ... and dryers are available, and can opt to receive an ... that maintains the machines monitors them via the Internet. , ...
... Abstracts Accepted for Presentation at ASCO, SOUTH SAN FRANCISCO, ... today that it will hold an investor and,analyst briefing in ... Clinical Oncology (ASCO) from 6:00 p.m. to 8:00 p.m. CT,on ... A. Scangos, PhD, President and Chief Executive Officer -- ...
Cached Biology Technology:AMT Accesses Technology for Treatment of Duchenne Muscular Dystrophy 2AMT Accesses Technology for Treatment of Duchenne Muscular Dystrophy 3Better business decisions with real-time data 2Better business decisions with real-time data 3Exelixis Announces June 2 Webcast of Its ASCO Investor and Analyst Briefing 2Exelixis Announces June 2 Webcast of Its ASCO Investor and Analyst Briefing 3Exelixis Announces June 2 Webcast of Its ASCO Investor and Analyst Briefing 4
(Date:4/15/2014)... 15, 2014 New research, partially funded by the ... shows that consumers can improve their diets simply by ... daily meals. , In a study ... Nutrition Sciences , lead author Theresa Nicklas, DrPH, of ... Nutrition Examination Survey datasets from 2005-2010 and evaluated the ...
(Date:4/14/2014)... pill to swallow, but if you,re over 24 years ... of your cognitive motor performance, according to a new ... a psychology doctoral student, associate professor Mark Blair, Thompson,s ... science doctoral student, deliver the news in a just-published ... one of the first social science experiments to rest ...
(Date:4/14/2014)... - High levels of the greenhouse gas methane were ... not thought to be an important emissions source, according ... universities. The findings could have implications for the evaluation ... The study, which is one of only a few ... methane gas levels in the air above wells, identified ...
Breaking Biology News(10 mins):Eating rice boosts diet quality, reduces body weight and improves markers for health 2Eating rice boosts diet quality, reduces body weight and improves markers for health 3Study says we're over the hill at 24 2'Problem wells' source of greenhouse gas at unexpected stage of natural gas production 2
... immune system has been shown by study of one of the ... The microRNA acts as a lynchpin to balance the response of ... have a similar vital role. , Cells of the immune system ... cells and the mice develop symptoms similar to those of human ...
... a link between massive volcanic eruptions along the east coast ... million years ago and a period of global warming that ... tropics and more than six degrees in the Arctic. , ... , The study is important, experts say, because it ...
... valley adjacent to the Oak Ridge National Laboratory's Y-12 ... the facility between 1951 and 1983 leaches into groundwater ... contaminated site. , But soon, Florida State University ... team will help clean up the mess. , ...
Cached Biology News:Minuscule molecules pack a powerful punch 2Minuscule molecules pack a powerful punch 3Volcanic eruptions, ancient global warming linked 2Volcanic eruptions, ancient global warming linked 3'Hidden-hero' microbes in soil, water may help naturally clean toxic sites 2
... Combining linear motor and ballscrew ... pre-engineered Cartesian solutions that include ... management, and motors., , ... Pass through high-flex cabling for ...
UGT1A6 (D-20)...
... T Squareds patented high efficiency dynamic valve ... With the most compact, lightweight package in ... use in portable air and gas applications., ... high efficiency. , Includes DC Motor. ...
... designed for moving loads quickly and accurately. ... output while limiting overall size. The P5S-P ... ball bearings guided on two rails., ... provide energy absorption and controlled deceleration , ...
Biology Products: