Navigation Links
MacroGenics Enters Global Research Collaboration and License Agreement with Pfizer
Date:10/26/2010

ground

MacroGenics' DART technology enables the generation of highly stable antibody-based therapeutic molecules that can simultaneously target two different antigens. DART therapeutics can accommodate virtually any variable region sequence in a "plug-and-play" fashion, are potent, and have very favorable manufacturing properties. To date, the company has engineered over 65 different DART proteins and has completed multiple in vitro and in vivo proof-of-concept studies in a variety of disease models. The company has been able to produce DART proteins in both bacterial and mammalian expression systems. DARTs also have been engineered with an Fc domain, which confers them with additional properties, such as Fc receptor binding and extended half-life. This functionality can be further expanded with the inclusion of MacroGenics' proprietary Fc domain portfolio. MacroGenics has established and continues to expand a significant patent estate around its DART technology.

About MacroGenics

MacroGenics is a private, venture-backed biotechnology company that focuses on the discovery, development and delivery to patients of novel biologics for autoimmune disorders, cancer and infectious diseases. Since its founding in 2000, the company has built a fully-integrated set of capabilities in antibody-based product development. The company has generated a proprietary pipeline of innovative product candidates by leveraging its three core technology platforms. These proprietary platforms include: (1) cancer stem-like cells; (2) DART technology, which allows the company to incorporate multiple specificities within a single molecule; and (3) Fc optimization, which enhances antibody-dependent effector functions. The company's lead program, teplizumab, is an anti-CD3 antibody. Teplizumab is being investigated in Phase 3 trials for the treatment of autoimmune diseases in collaboration with Eli Lilly and Company. For more information about MacroGenics, please
'/>"/>

SOURCE MacroGenics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. MacroGenics Receives NIH Grant Funding of $9.8M for Three Projects; Funding Further Advances DART Platform and Infectious Disease Portfolio
2. MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus
3. Paulo F. Costa Joins MacroGenics Board of Directors
4. MacroGenics Appoints New Vice President of Business Development
5. MacroGenics Raises $25M in Series D-2 Financing
6. Shrink Nanotechnologies Enters Into Agreement to Produce High Content Screening Software Called Stemage for its StemDisc Stem Cell Culturing Products
7. HumanTouch Expands Services to the Centers for Disease Control and Prevention as a Prime Contract Holder as Part of $1.0 Billion Contract
8. NSF renews Centers for Nanotechnology in Society
9. Tongjitang Chinese Medicines Company Enters into Share Transfer Agreement
10. ReGear Life Sciences Partners with Life Care Centers of America
11. Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... PLAINSBORO, N.J. (PRWEB) May 21, 2015 ... initial circulation audit and been admitted to BPA ... result, BPA Worldwide will track audience data for ... geographic coverage. , “By becoming a member ... steadfast dedication to providing our clients with the ...
(Date:5/21/2015)... YORK , May 21, 2015  Prima Biomed ... company that is striving to become a leader in ... cancer, recently announced that the final CVac data from ... shown a clear trend for a clinically meaningful improvement ... in second remission patients. In the group ...
(Date:5/21/2015)... Calif. , May 21, 2015  The ... Orrin Hatch (R-UT) and Amy Klobuchar ... Extensions Now Accelerating Cures & Treatments, or OPEN ... rare disease patient advocacy organizations, this bipartisan legislation ... and affordable medicines to rare disease patients by ...
(Date:5/21/2015)... W. R. Grace & Co. (NYSE: ... Germany has received good manufacturing practice (GMP) certification ... Pharmaceutical Excipient Council (IPEC) Foundation. , ... FP brand of pharmaceutical grade excipient silica gels ... Bay, Maryland (USA) and Sorocaba, Brazil locations. The ...
Breaking Biology Technology:Specialty Pharmacy Times Joins BPA Worldwide 2Correction Continues after Big Move - BrokerBank Securities, Inc. 2Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2
... 10 Thoratec,Corporation (Nasdaq: THOR ), a ... today that it will be participating in the,Bear ... Gary Burbach, president and chief executive officer, ... 3 p.m., Eastern Daylight Time (12 p.m.,Pacific Daylight ...
... civil settlement with the U.S. Department of Justice ... federal False Claims Act,relating to Anzemet(R) involving one ... The settlement relates to government claims that API ... increased the cost of,government reimbursements for the drug. ...
... Inc. (Pink,Sheets: BMXSF), is pleased to announce ... Agricultural Developments Pty. Ltd. (http://www.scadev.net ) ... renewable bio-fuels,waste water management and related renewable ... is developing large vertical,integrated Agri-Energy plants worldwide. ...
Cached Biology Technology:Biomaxx Systems Inc. Selected as Technical Consultant By Southern Cross Agricultural Developments 2
(Date:5/7/2015)... Sweden , May 7, 2015 ... touch fingerprint sensors, FPC1022 and FPC1035, FPC,s smallest ... and FPC1035 are mainly considered for integration on ... size gives smartphone OEMs increased possibilities to integrate ... The decreased size also improves possibilities for module ...
(Date:4/27/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... first week of May, 2015 and will be fulfilling ... Gino Pereira , Chief Executive Officer ... as Wocket® enters the consumer market. We would like ...
(Date:4/20/2015)... -- The announcement comes as demand for ... (GRM), Ireland,s foremost records management company, ... up an impressive track record of clients within the first ... records management sector in Dubai . As ... and employ a further eight staff members at its Irish ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... A report published today concludes that the African lion is ... African lion once ranged continuously from Senegal to Nigeria, but ... 250 adult lions restricted to four isolated and severely imperiled ... lions. Led by Panthera,s Lion Program Survey ...
... the Fukushima 1 Nuclear Power Plant in 2011, Japanese plant ... contamination on wild and cultivated plants. In a special issue ... examine the potential adverse effects of radioactivity on nature and ... on the efforts of a research group led by Yoshihiro ...
... Tobacco smoking by pregnant women has long been ... adverse effects on the development of a fetus. ... outcomes, including low birth weight, sudden infant death syndrome, ... and nicotine use in offspring. Despite this extensive literature, ...
Cached Biology News:Lions are critically endangered in West Africa 2Lions are critically endangered in West Africa 3Microalgae and aquatic plants can help to decrease radiopollution in the Fukushima area 2Maternal stress hormones and maternal smoking increase daughter's risk of nicotine dependence 2
... a new generation dispenser combining the most versatile ... performance of the existing Multidrop dispensers. , ... starting from 500 nl up to 2500 l ... ,It is optimized for multiple plate formats (96, ...
... lower consumption of reagents and increased ... Multidrop 384 is an automated dispenser ... dispensing into 384- and 96-well plates.This ... can easily switch from 96- to ...
MBS 384 well satellite block unit with height adjusting heated lid, 384 well block holds 1 x 0.04 ml 384 well plate...
384 well block MBSr. Robot compatible block ejection mechanism. Stackable. (384 well block - holds 384 well plate)...
Biology Products: