Navigation Links
MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus
Date:7/13/2009

ROCKVILLE, Md., July 13 /PRNewswire/ -- MacroGenics, Inc. today announced the initiation of the PARADIGM trial, a Phase 2 clinical study evaluating MGAWN1, a humanized monoclonal antibody, for the treatment of individuals with suspected central nervous system infection due to West Nile Virus (WNV). MacroGenics, a privately held biotechnology company that develops immunotherapeutics to treat autoimmune disorders, cancer and infectious diseases, was awarded a $50 million contract in September 2006 from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to support the development of MGAWN1.

The PARADIGM trial is a randomized, double-blind, multicenter, placebo-controlled study that is designed to evaluate the safety and efficacy of MGAWN1 in patients greater than or equal to 18 years of age with signs and symptoms of acute West Nile Neuroinvasive Disease. Approximately 20 sites in North America will be utilized for the conduct of the PARADIGM trial. For more information on the PARADIGM trial, please see www.clinicaltrials.gov.

MacroGenics also announced today the completion ofa Phase 1 study of MGAWN1 in healthy volunteers, with the last patient having completed treatment in late 2008. This randomized, double-blind, dose-escalation cohort study was designed to evaluate the safety, tolerability, and pharmacokinetics of a single infusion of MGAWN1 in healthy adults. The study demonstrated the drug to be safe and well tolerated at all doses tested.

"We are delighted with the initiation of the PARADIGM trial as well as the completion of the Phase 1 trial," stated Scott Koenig, M.D., Ph.D., President and CEO of MacroGenics. "Currently, there are no approved treatments for individuals with severe West Nile Virus infection. These patients are hospitalized and receive
'/>"/>

SOURCE MacroGenics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Paulo F. Costa Joins MacroGenics Board of Directors
2. MacroGenics Appoints New Vice President of Business Development
3. MacroGenics Raises $25M in Series D-2 Financing
4. MacroGenics Acquires Raven Biotechnologies
5. Jeffrey H. Buchalter Joins MacroGenics Board of Directors as Chairman
6. China-Biotics, Inc. Announces Conference Call to Discuss Fourth Quarter and Full Year 2009 Financial Results
7. Mirixa Corporation Announces Key New Hires
8. Harvest Technologies Announces Completion of Patient Enrollment in its 60 Patient Clinical Trial in India Using Autologous Adult Stem Cells to Treat Patients With Non-Reconstructable Critical Limb Ischemia
9. Amylin Pharmaceuticals Announces Positive Results from Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment for Obesity
10. Cornerstone Therapeutics Inc. Announces Record Date and Meeting Date for Special Meeting of Stockholders for Vote with Respect to Charter Amendments
11. DOR BioPharma Announces Issuance of European Patent for its LPM(TM) Oral Drug Delivery Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... Spartan Bioscience announced today that Health Canada ... It detects CYP2C19 genetic mutations in less than 60 ... RX CYP2C19 System is the first near-patient DNA test ... Due to the system’s ease of use, Health Canada ... professionals such as doctors, nurses, pharmacists, and laboratory technicians, ...
(Date:10/30/2014)... Grace Century portfolio project, Provia Laboratories ... of the Board, to the National Stem Cell Ethics ... made by the Ministry of Health on behalf of the ... , More than a year after Bahamian Parliament passed the ... Perry Christie said the government has completed the accompanying regulations ...
(Date:10/30/2014)...  Regado Biosciences, Inc. (Nasdaq: RGDO ), ... and live audio webcast on Thursday, November 6, 2014, ... 2014 financial results. Interested participants and investors ... for domestic callers or (412) 902-4276 for international callers. ... investor relations section of the Regado website at ...
(Date:10/27/2014)... Ryan Carfley , Managing Partner at Personify ... Bryan Hamilton, the publisher of the Triangle Business Journal, and ... Research Triangle region of North Carolina. , Just a few ... include the role of social media in recruitment, recruiting ... the unique role that Millennials play in the workplace today. ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3Regado Biosciences to Provide Third Quarter 2014 Financial Results 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3
... FRANCISCO, Aug. 30 BioSpace, the leading ... along with BayBio unveiled this,morning the 11th ... The,campaign features both a regional promotional Hotbed ... conjunction with the economic and,workforce development initiatives ...
... ICx Technologies, a developer of,advanced technology solutions for ... detection business unit, based in Albuquerque, has been,awarded ... of Homeland Security,(DHS) to continue development of a ... granted the award to commence Phase II activities ...
... PRINCETON, N.J., Aug. 30 Medarex, Inc.,(Nasdaq: MEDX ... at the,Thomas Weisel Partners Healthcare Conference at 11:30 AM ... being held at the Four,Seasons Hotel in Boston, Massachusetts. ... for replay through the Webcast page in,the Investor Relations ...
Cached Biology Technology:BioSpace and BayBio Launch 11th Edition of Biotech Bay(TM) Hotbed Map Campaign 2ICx Awarded $1.5 M Contract by Department of Homeland Security for Development of Next Generation Bio Aerosol Systems 2Medarex to Present at Thomas Weisel Partners Healthcare Conference 2007 2
(Date:10/29/2014)... kind of stem cell, those referred to as ,facultative, ... is apparently nothing that differentiates these cells from the ... they retain the capacity to become stem cells again. ... an organ that hosts cells that stimulate tissue growth, ... case of a transplant. Knowledge of the underlying ...
(Date:10/29/2014)... October 27, 2014 — Cambridge, MA and Hebei, China ... the complete, high quality sequencing of the Jujube genome. ... Rhamnaceae family, and the Jujube genome is particularly difficult ... other complicating factors. It is the first time that ... sequenced. This study has been recently published in ...
(Date:10/29/2014)... PA, October 29, 2014 – Ghrelin is a hormone ... food intake. Alcohol is commonly viewed as a psychoactive ... also a highly caloric food. , This knowledge, ... the hypothesis that ghrelin has the potential to stimulate ... tested this in humans and found that, as they ...
Breaking Biology News(10 mins):A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2BGI Tech and Hebei Agricultural University complete the genome sequencing of the jujube tree 2Ghrelin stimulates an appetite for drinking alcohol 2
... Then it was Jeopardy. Now computers are at ... automate the scientific process itself. An interdisciplinary team ... Research Corporation, Inc., has taken a major step toward ... raw experimental data from a biological system and derive ...
... -- An eight-year study has concluded that increasingly frequent ... have pushed some aquatic desert ecosystems into "catastrophic regime ... The findings, just published in the journal Freshwater ... aquifers for urban water use, and land management may ...
... of Naval Research scientist Dr. Roshdy George S. Barsoum ... for the development of a revolutionary coating material that ... HybridSil Fire/Blast, acts like a force field that surrounds ... ballistic- and fire-resistant. "You can take an existing ...
Cached Biology News:Robot biologist solves complex problem from scratch 2Robot biologist solves complex problem from scratch 3Severe drought, other changes can cause permanent ecosystem disruption 2Severe drought, other changes can cause permanent ecosystem disruption 3Spray-on protective coating wins 'R&D 100' Award 2
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
MAb to HLA, Class II-DR+DP Dry Ice: No Preservative: NaN3 Availability When Not in Inventory: 14-21 Business Days...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
... Disposable. Virgin, optically clear polystyrene with ... alphanumeric coordinates for cell counting. 100% ... is a new product number, created ... If showing no availability yet, please ...
Biology Products: