Navigation Links
MacroGenics Announces Margetuximab (MGAH22) Phase 1 Data Presentation at ASCO; Initiates Phase 2 Clinical Study to Evaluate Activity of Margetuximab in Patients with Metastatic Breast Cancer
Date:5/21/2013

ROCKVILLE, Md., May 21, 2013 /PRNewswire/ -- MacroGenics, Inc. today announced that an abstract titled, "Phase 1 study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody (MAb), in patients with advanced solid tumors expressing the HER2 oncoprotein," will be presented at the 2013 Annual Meeting of the American Society of Clinical Oncology during the Developmental Therapeutics - Immunotherapy Oral Abstract Session on Monday, June 3 at 4:15 – 4:30 PM.  The presentation will describe the results of a first-in-human study of MacroGenics' next-generation anti-HER2 monoclonal antibody, margetuximab, which is being developed to treat HER2-expressing tumors.  

MacroGenics has optimized the Fc region of margetuximab to increase cancer cell killing via Antibody-Dependent Cell-mediated Cytotoxicity (ADCC).  Margetuximab also has shown improved control of tumor growth in human tumor xenograft models in mice as compared to that of anti-HER2 antibodies with a wild type Fc region.  A development goal for margetuximab is to enable the treatment of a broader population of patients than those eligible for treatment with current HER2-targeted therapies.

MacroGenics also announced that the first patient has received study drug in a Phase 2 clinical study evaluating margetuximab in patients with metastatic breast cancer.  This study is designed to evaluate the activity of margetuximab in up to 41 patients with metastatic breast cancer whose tumors express a moderate level of the oncoprotein, HER2, represented by a 2+ score by immunohistochemistry.  These tumors must also lack evidence of HER2 gene amplification as determined by FISH testing.  The trial is being conducted at six sites across the United States.  For more information on the clinical trial, please see www.clinicaltrials.gov.

"To date, the results of our Phase 1 s
'/>"/>

SOURCE MacroGenics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. MacroGenics Receives Milestone Payment as Part of Its Global DART™ Alliance with Boehringer Ingelheim
2. Revolutionary Science Announces New Automatic and Manual Colony Counting Products
3. Nanonex Announces the Shipment and Installation of an Innovative Nanoimprint Lithography System for Fully Automated Manufacturing
4. SoundConnect Announces Microsoft Lync Release in Canada
5. GLM Displays Announces All-in-One Formulate Fusion Fabric Display Kit
6. Rhythm Announces Phase 1b Results for Ghrelin Prokinetic RM-131 for Gastroparesis in Patients with Type 1 Diabetes
7. YouTube Channel on SEO Tips Surpasses 175,000 Views, Announces JM Internet Group
8. Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech
9. DNA Genotek Inc. Announces Spit for Africa Program
10. Metabolic Solutions Development Company announces publication of data describing a new drug target for diabetes
11. Discovery Labs Announces Completion of $14.25 Million Public Offering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... MINNEAPOLIS , July 23, 2014 /PRNewswire/ - ... industrial biotechnology company producing sustainable chemicals, today announced that ... in full their option to purchase an additional ... offering price of $12.00 per share, less underwriting ... announced underwritten public offering of 2,800,000 shares of ...
(Date:7/23/2014)... MENLO PARK, Calif. , July 23, 2014 /PRNewswire/ ... based investment firm, today announced the closing of Sofinnova ... $500 million and in excess of the initial fund ... on helping entrepreneurs build successful biotechnology companies. Consistent with ... companies with promising later stage clinical programs, along with ...
(Date:7/23/2014)... Columbia, MD (PRWEB) July 23, 2014 ... Booth and ChirpE Mobile App, AACC Pathfinder, in its ... event offerings. AACC’s annual meeting is planned for July ... is the place to be to connect with global ... medicine, lab management, and other areas of breaking science ...
(Date:7/22/2014)... LAKES, N.J. , July 22, 2014 The ... BDX ) has declared a quarterly dividend of ... to holders of record on September 9, 2014. The indicated ... About BD BD is a leading medical technology ... of the world,s most pressing and evolving health needs. Our ...
Breaking Biology Technology:BioAmber announces exercise in full of underwriters' option in connection with previously priced follow-on offering 2BioAmber announces exercise in full of underwriters' option in connection with previously priced follow-on offering 3Sofinnova Raises $500 Million Biotech Venture Fund 2AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 2AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 3
... today announced that Pat Basu, M.D., M.B.A. , ... as Chief Medical Officer. Dr. Basu has just completed ... a White House Fellow, America,s most prestigious and selective ... will play a critical role in advancing vRad,s efforts, ...
... Sequenom, Inc. (NASDAQ: SQNM ), a life ... the launch of its iPLEX ADME PGx panel developed ... distribution, metabolism, and excretion (ADME). This Research Use Only ... polymorphisms (SNP), insertions and deletions (INDELS) and copy number ...
... HILL, MA -- Boston College researchers have discovered two ... chemical vapor deposition, finding a disorderly tangle of tube ... nanoscopic tubes, according to a report in the latest ... using a thin layer of catalyst, Professor of Physics ...
Cached Biology Technology:vRad Adds White House Fellow, Dr. Pat Basu, to Its Leadership Teams 2Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 2Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 3Boston College Researchers discover 2 early stages of carbon nanotube growth 2
(Date:7/23/2014)... Genetic analysis of Antarctic fur seals, alongside decades ... the effect of climate change on a population ... week, the findings show that the seals have ... availability that are associated with climate conditions. Despite ... this fitness is not passing down through generations, ...
(Date:7/23/2014)... issued a high health risk warning for Yellowknife and ... due to forest fires. In the image taken ... along normal wind patterns. Fire is an obvious ... is not quite so obvious and its effects are ... fire (forest, brush, crop, structure, tires, waste or wood ...
(Date:7/23/2014)... people around the world have no access to clean ... 3.4 million people die from water-related diseases every year. ... making a contribution to solving this problem. Working with ... of the Functional Materials Laboratory, the 23-year-old spent a ... , "What makes our DrinkPure filter unique is that ...
Breaking Biology News(10 mins):Genetic study shows major impact of climate change on Antarctic fur seals 2Genetic study shows major impact of climate change on Antarctic fur seals 3ETH student develops filter for clean water around the world 2
... of the world,s most widely used pesticides, wreaks havoc ... three-quarters of them and turning one in 10 into ... California, Berkeley, biologists. The 75 percent that are ... to reproduce in the wild, reports UC Berkeley,s Tyrone ...
... HARBOR, N.Y. (Mon., Mar. 1, 2010) -- The ... acids as affinity reagents is a simple yet powerful ... processes. Analysis via mass spectrometry rather than western blotting ... thousands of proteins from complex mixtures. But this ...
... Rice University researchers have found a way to ... two-dimensional quilt that offers new paths of exploration for ... of graphene materials in microelectronics that scale well below ... New research from the lab of Pulickel Ajayan, Rice,s ...
Cached Biology News:Pesticide atrazine can turn male frogs into females 2Pesticide atrazine can turn male frogs into females 3Pesticide atrazine can turn male frogs into females 4Protein-bait interactions, display libraries featured in Cold Spring Harbor Protocols 2Rice researchers make graphene hybrid 2Rice researchers make graphene hybrid 3
... enterprise microarray informatics platform for microarray data storage, ... and use it forever without paying ongoing license ... Acuity has all the analysis tools you need ... quality control statistics and normalization, all the way ...
... industry standard microarray image analysis software because ... analysis tools, visualizations, automation capabilities, performance and ... with every GenePix scanner, and it also ... all types of arrays. A wide range ...
A univariate (peak height or area) quantitative multi-component analysis package....
... H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH 2 (Disulfide ... peptide and 1 ... I-labelled peptide, please see ... ([ 1 2 ...
Biology Products: