Navigation Links
Machine Preservation Significantly Improves Kidney Transplant Survival Over 3 Years Compared to Traditional box of ice

CHICAGO, February 22, 2012 /PRNewswire/ --

Study results published today in the New-England-Journal of Medicine  show that 3-year graft survival is significantly greater in all transplanted kidneys machine perfused in the LifePort® Kidney Transporter compared to those stored in a traditional box of ice (static cold storage) (91% vs. 87%, p=0.04).[1] The graft survival difference at three years was most pronounced for kidneys from expanded criteria donors (86% vs. 76%, p=0.01). Expanded criteria donors are those over the age of 60 or those over 50 with health conditions such as high blood pressure, stroke or poor kidney function. Over the past decade, kidney donations from expanded criteria donors have increased considerably and today comprise nearly half of the deceased donor kidneys transplanted in the US and EU.[2,3]

When the results are analysed by donor type, they show that 3-year graft survival after machine perfusion compared to static cold storage was also significantly superior for kidneys donated after brain death (91% vs. 86%, p=0.02).

Machine-perfused kidneys with delayed graft function (DGF) - a delay in the recovery of renal function that requires dialysis within the first week after transplantation[2] - had better 3-year graft survival (77%) than cold stored kidneys with DGF (62%).

"It is very interesting to see that the benefits in graft survival seen in this landmark study at 1 year[3] with machine perfusion persist after 3 years compared to traditional cold storage methods," said lead author Cyril Moers, University Medical Center Groningen, The Netherlands. "Since a growing number of organs available for transplantation come from older donors or from people with more complex medical conditions, it is particularly welcome that machine perfusion offers significant improvements for 3-year graft survival in kidneys from these donors and is a real step forward in kidney transplantation."

About the trial

  • The Machine Preservation Trial was a landmark, investigator-driven study, run by an independent scientific steering committee across the Netherlands, Belgium and the German federal state of North Rhine Westphalia, in collaboration with the Deutsche Stiftung Organtransplantation and Eurotransplant International Foundation (the international organ exchange organisation for Austria, Belgium, Croatia, Germany, Luxembourg, The Netherlands and Slovenia) as the central trial assistance desk. Principal investigators were Rutger Ploeg (Oxford, United Kingdom and Groningen, The Netherlands), Andreas Paul (Essen, Germany) and Jacques Pirenne (Leuven, Belgium).
  • The study was the first large randomised, prospective trial to compare machine perfusion with traditional cold static storage.
  • Three-year follow-up data were collected on all 672 recipients of consecutive kidneys donated after brain death or after cardiocirculatory death in the main data set, as well as 164 recipients of kidneys donated after cardiocirculatory death in the extended data set. One kidney from each of the 336 pairs included was randomly assigned to machine perfusion, and the contralateral organ to cold storage.
  • Earlier 12 month results from the Machine Preservation Trial, also published in the New England Journal of Medicine, showed that in transplanted kidneys preserved and transported in the LifePort Kidney Transporter, the odds of experiencing a delay in recovery of kidney function were 43% lower, and that these kidneys were 48% less likely to fail within a year compared to those stored in the traditional box of ice.[5]

About the LifePortKidney Transporter

LifePort is a device that preserves a donated kidney before it is transplanted. Designed to provide a sealed and sterile environment from the time of recovery until transplantation, LifePort gently pumps a specifically formulated solution through the kidney. This is referred to as 'machine perfusion' and is an important contrast to the traditional method of storing and transporting donated kidneys - packed in a box of ice (static cold storage).

About Organ Recovery Systems

Organ Recovery Systems ( is the world's leading provider of machine perfusion products to the transplant community, supporting over 120 transplant programs worldwide with its LifePortKidney Transporter and organ preservation and flush solutions.

1. Moers C, Pirenne J, Paul, A, Ploeg RJ. Machine perfusion or cold storage in deceased-donor kidney transplantation. N.Eng J Med 2012;366:770-1.

2. Eurotransplant data provided on request.

3. OPTN. Available at

4. Johnston TD, Thacker LR, Jeon H et al. Sensitivity of expanded-criteria donor kidneys to cold ischaemia time. Clin Trans 2004;18:28-32.

5. Moers C, Smits JM, Maathuis, MJ et al. Machine perfusion or cold storage in deceased-donor kidney transplantation .N Engl J Med 2009;360:7-19.

SOURCE Organ Recovery Systems
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Hemodialysis Machine Industry 2012 Global & China Market Research Report - ReportsnReports
2. Life Technologies Ion Personal Genome Machine Receives San Diegos CONNECT Most Innovative New Product Award
3. NIST polishes method for creating tiny diamond machines
4. Queens University professor uses nanotechnology to prolong machine and engine life
5. Reportlinker Adds Strategic Analysis of European Human Machine Interface (HMI) Market
6. The 20th Century Reanalysis Project: A time machine for climate scientists
7. Study measures single-molecule machines in action
8. Inspired by a cotton candy machine, engineers put a new spin on creating tiny nanofibers
9. New Mobile Blister Packing Technology Launched by Packaging Machinery Manufacturer, Sepha Ltd
10. UK Based Machinery Manufacturer, SEPHA, Thrives Despite Downturn
11. Argonne Scientists Use Bacteria to Power Simple Machines
Post Your Comments:
(Date:11/24/2015)... 24, 2015  Asia-Pacific (APAC) holds the third-largest ... market. The trend of outsourcing to low-cost locations ... higher volume share for the region in the ... margins in the CRO industry will improve. ... ( ), finds that the market earned ...
(Date:11/24/2015)... , Nov. 24, 2015 /CNW/ - iCo Therapeutics ... today reported financial results for the quarter ended ... expressed in Canadian dollars and presented under International ... United States ," said Andrew Rae ... advancements regarding iCo-008 are not only value enriching ...
(Date:11/24/2015)... -- Clintrax Global, Inc., a worldwide provider of clinical research services headquartered ... the company has set a new quarterly earnings record in Q3 ... posted for Q3 of 2014 to Q3 of 2015.   ... , with the establishment of an Asia-Pacific ... United Kingdom and Mexico , with ...
(Date:11/24/2015)... -- SHPG ) announced today that Jeff Poulton ... th Annual Healthcare Conference in New York City ... EST (1:30 p.m. GMT). --> SHPG ) announced today ... the Piper Jaffray 27 th Annual Healthcare Conference in ... 2015, at 8:30 a.m. EST (1:30 p.m. GMT). --> ...
Breaking Biology Technology:
(Date:10/29/2015)... 2015  The J. Craig Venter Institute (JCVI) policy ... and Biosecurity: Lessons Learned and Options for the Future," ... Human Services guidance for synthetic biology providers has worked ... --> --> Synthetic biology promises ... to pose unique biosecurity threats. It now is easier ...
(Date:10/29/2015)... NXTD ) ("NXT-ID" or ... the growing mobile commerce market and creator of ... leading marketplace to discover and buy innovative technology ... on StackSocial for this holiday season.   ... a biometric authentication company focused on the growing ...
(Date:10/27/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), the ... has adopted the Synaptics ® ClearPad ® ... its newest flagship smartphones, the Nexus 5X by LG ... --> --> Synaptics works closely ... collaboration in the joint development of next generation technologies. ...
Breaking Biology News(10 mins):