Navigation Links
MS Drug Development Agreement Based on WEHI's Medicinal Chemistry
Date:7/2/2008

MELBOURNE, Australia, July 2 /PRNewswire/ -- Research conducted at The Walter and Eliza Hall Institute (WEHI) has contributed significantly to a major licensing agreement signed between Australian biotechnology company, Bionomics, (ASX:BNO) and Germany-based pharmaceutical company, Merck Serono.

Under the Development and Licensing Agreement, Merck Serono will seek to develop new treatments for multiple sclerosis (MS) and other autoimmune conditions. These prospective treatments will be based upon compounds from Bionomics' Kv1.3 program, which WEHI had a fundamental role in developing.

The Kv1.3 program has its origins in the late 1990s, when WEHI's Dr Jonathan Baell and collaborators discovered that certain derivatives of a natural product called khellinone could block a potassium channel called Kv1.3. This potassium channel selectively inhibits autoreactive T cells, such as those that attack the myelin sheath in people with MS.

Dr Baell says, "Our research in this area had a rocky start, but when our first patents were published in 2003, Start-Up Australia approached us with an interest in licensing the intellectual property. This came to fruition in late 2004 through their investee company, Iliad, which was able to resource the medicinal chemistry effort required."

In 2005, Iliad was acquired by Bionomics, which further accelerated progress with the program.

Dr Baell continues, "There was a great meeting of minds between chemists from WEHI and Bionomics, leading to a significant expansion of the patent portfolio. Bionomics also established an in-house biology platform that effectively serviced the whole program."

"During the whole process, every scientist at WEHI and Bionomics maintained a focus upon what we were trying to achieve: a treatment for MS, a debilitating disease that is tragically common among young adults. Our progress and achievements to date demonstrate that with intense tenacity and a collaborative approach, academic drug discovery programs can produce great outcomes."

WEHI's research achievements were recognised on a national basis by the Royal Australian Chemical Institute with the 2004 Biota Award to Dr Baell for medicinal chemistry and the award of an NHMRC Industry Fellowship to Dr Andrew Harvey, who became an important driver of the program, along with Bionomics' medicinal chemistry colleagues, Drs Flynn, Chaplin, Paul and Mould.

For further information, contact

Brad Allan,

WEHI Communications Manager:

tel +61 3 9345 2345;

mobile 0403036116


'/>"/>
SOURCE Walter and Eliza Hall Institute
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Joseph B. Bolen, Ph.D. from Millennium to Conference Chair Cancer Sessions at IBCs Drug Discovery & Development of Innovative Therapeutics Conference
2. Exelixis and GlaxoSmithKline Agree to Successfully Conclude Six-Year Discovery and Development Collaboration
3. Cystic Fibrosis - Axentis Pharma Takes Over Patents and Continues Development of Innovative Platform Technology
4. Lixte Biotechnology Holdings Announces Extension of Its Cooperative Research and Development Agreement With The National Institute of Neurological Disorders and Stroke, National Institutes of Health, for Development of Anti-Brain Cancer Drugs
5. U.S. Commerce Secretary Gutierrez Cuts Ribbon on MaxWell Biocorporations New Pharmaceutical Development Center and Quality Control Laboratory in Ukraine
6. Portola Pharmaceuticals Names William Lis Vice President of Business Development and Commercial Operations
7. Stason Pharmaceuticals, Inc. Appoints Diana Wood as Vice President, Business Development
8. Discovery by UC Riverside physicists could enable development of faster computers
9. Rosetta Genomics Announces Three New Diagnostic Tests to Enter Development
10. EntreMed Appoints Thomas H. Bliss as Senior Vice President of Corporate and Business Development
11. Nuevolution Announces Research and Development Collaboration with Merck & Co. Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... , Dec. 7, 2016  Biocom, the association for the ... statement below following passage of 21 st Century Cures ... November 30 by a 392-26 vote and in the Senate ... be attributed to Joe Panetta , president & CEO ... will give hope to millions of patients around the world. ...
(Date:12/7/2016)...  Vyriad Inc. announced today the appointment of ... Directors. "We are delighted to welcome Al ... develop our oncolytic viruses as the next generation of ... , MD, PhD, CEO of Vyriad. "Al and his ... passion for making a difference for cancer patients—their philanthropy ...
(Date:12/7/2016)... BOULDER, Colo. , Dec. 7, 2016  Muse ... genome engineering technologies, today announced that Dr. Kevin ... member of the Board of Directors. ... , who becomes the company,s Chief Science Officer as ... and Executive Director of the BioDesign Center at the ...
(Date:12/7/2016)... -- Regen BioPharma Inc. (OTCQB: RGBPP) In a ... a team of scientists in Guangzhou, China ... expression of NR2F6 in patients with early cervical cancer correlates ... cervical cancer tissue as well as in the normal tissue ... interesting study and the first that I am aware of ...
Breaking Biology Technology:
(Date:11/30/2016)... , Nov. 30, 2016 Not many of us realize that we ... of recovery so we need to do it well. Inadequate sleep levels have been ... blood pressure, stroke, diabetes, and even cancer. Maybe now is the best ... that could help them to manage their sleep quality? ... ...
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The ... Identification Systems) ... Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of ...
(Date:11/22/2016)... 2016   MedNet Solutions , an innovative SaaS-based ... clinical research, is pleased to announce that the company ... Life Sciences Awards as "Most Outstanding in eClinical ... year of recognition and growth for MedNet, which has ... iMedNet ™ , MedNet,s flagship ...
Breaking Biology News(10 mins):