Navigation Links
MIT researcher addresses biomedical engineering challenges
Date:2/15/2008

the development of novel ways to introduce DNA strands into human cells, a necessary step in gene therapy to correct genetic abnormalities or predispositions to disease.

Traditionally, such DNA insertions have been carried out using viruses that have a natural ability to penetrate the cell and insert segments of DNA into the nucleus. But these viruses can sometimes have dangerous side effects, and have been responsible for deaths in some early gene-therapy trials.

Were working on polymers that could deliver DNA as efficiently as viruses, that could put a DNA strand wherever you want, without the safety problems of viruses, Langer says. In addition, they could be cheaper and easier to manufacture.

So far, the problem has been that such synthetic vectors have been far less efficient in carrying out the delivery. But in early tests conducted by Jordan Green and Dan Anderson in Langers lab, some polymers have been as effective at delivering the DNA strands to their target as the viruses, but with 100 times less toxicity.

Such new polymers, Langer says, might eventually lead to new treatments for some kinds of cancer. And they may also enable the delivery of small interfering RNA segments (siRNAs), whose discovery led to a Nobel Prize in 2006. These may be used to combat a variety of diseases.

Anderson, Langer and graduate student Michael Goldberg have also been working on the design of chemicals similar to lipids in the body, called lipidoids that could be used to deliver drugs including siRNA to specific tissues in the body and release them in a controlled way. Already more than 50 promising compounds have been found and are undergoing tests. That work is going quite well, Langer says.

Tissue engineering is another important area of ongoing research, Langer says. One key project is growing replacements for damaged tissues such as the neurons damaged by spinal cord injuries that lead to paralysis. Using a neuronal sc
'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Sigma-Aldrich Announces New Prestige Antibodies(TM) Line for Proteomics and Cell Biology Researchers
2. A researcher of UPV/EHU has designed nanomagnets for industry
3. Stanford researchers hear the sound of quantum drums
4. Researchers at Leeds mine the Terahertz gap
5. Researchers create gold aluminum, black platinum, blue silver
6. Leading DHA Expert and Former NIH Researcher, Dr. Norman Salem, Jr., to Join Martek as Chief Scientific Officer
7. Researchers Pinpoint Best Treatment to Reduce Deadly USA300, MRSA Staph Infections
8. Researchers develop darkest manmade material
9. Boost for Malaria Vaccine Development by Combining Strengths of Dutch and American Researchers
10. Researchers use magnetism to target cells to animal arteries
11. Ames Laboratory researchers solve fuel-cell membrane structure conundrum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 23, 2014 Vermillion, Inc. (Nasdaq:   ... disease, announced today that investors including Oracle Investment ... LLC and several Vermillion directors have agreed to ... Vermillion,s common stock and warrants to purchase unregistered ... placement.  Under the terms of ...
(Date:12/22/2014)... Malvern, PA & Brussels (PRWEB) December 22, 2014 ... Education (CfPIE), the global leader of technical training ... Society for Clinical Data Management (SCDM) to ... training and certification programs —providing access to the ... The partnership extends SCDM members with 10% off when ...
(Date:12/22/2014)... 22, 2014  ( www.competitivehealth.com ) — Competitive Health ... bill review and advocacy service, has signed an agreement ... Savings discount health services marketplace. 63% of ... than they expected to pay. As part of an ... WellCard Savings is pleased to offer medical bill review ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Charm Sciences ... test for the Detection of Aflatoxin M1 in raw ... receive independent third party validation. The peer reviewed report ... of the Institute for Agricultural and Fisheries Research (ILVO-T&V) ... , Aflatoxin B1, the most toxic aflatoxin and ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... Technology Drives Ongoing Live-Cell Research, MELVILLE, ... (http://www.nikoninstruments.com ) and Northwestern University,s Feinberg School ... core microscopy imaging,center, establishing a partnership that ... critical feedback for Nikon,product development. One of ...
... with HIV the virus infects cells in the brain ... this causes no immediate problems, during the late-stages of ... of the brain that can cause death). Monkeys infected ... CNS damage and provide a good model of CNS ...
... Energy, manufacturer of Reuter Stokes radiation detection equipment, has ... and software associated with the SNS 8Pack neutron detector ... neutron detectors developed at Oak Ridge National Laboratory. ... system that was developed for the Department of Energy,s ...
Cached Biology Technology:Nikon Instruments Opens New Imaging Center at Northwestern University 2Nikon Instruments Opens New Imaging Center at Northwestern University 3GE Energy to market SNS-developed detector electronics system 2
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
(Date:12/11/2014)... 2014  Data Sciences International (DSI), the global ... new series of digital telemetry implants to meet ... series, part of the PhysioTel™ Digital platform, was ... physiologic data when incorporating functional endpoints into repeat-dose ... toxicology studies has evolved from short ECG strips ...
(Date:12/10/2014)... , Dec. 9, 2014 CIE San ... catalyst that provides the connective tissue that enhances care ... them to easily share client-level information; earned a second ... expand to organizations serving seniors aging in community and; ... partner on December 11 th 4-6p. ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... out on low early bird rates for the premier bone ... (IOF-ECCEO12), from March 21-24, 2012 will be held in in ... early bird rates: register by December 9, 2011 at ... international experts and key thought leaders... Plenary lectures:, ...
... treated with anticoagulants to thin the blood, but this ... have their blood tested regularly. Researchers at the Sahlgrenska ... of Technology have now devised a new method that ... fibrillation, or irregular heartbeat, is a very common heart ...
... available in German . , GLORIA is ... the Atmosphere". This complicated name refers to a novel type ... gases into its spectral colors. This allows for a very ... was developed by Forschungszentrum Jlich and Karlsruhe Institute of Technology ...
Cached Biology News:Register now for the European Congress on Osteoporosis & Osteoarthritis in Bordeaux 2New method for safer dosing of anticoagulants 2GLORIA: Unique climate research experiment worldwide 2GLORIA: Unique climate research experiment worldwide 3
... software has been designed and created in ... biologist friendly genotyping analysis tool. We incorporated ... groups into the software. Their main requirements ... and low acquisition cost. GeneMarker can ...
... the first fully automated proteomics workcell. It ... with complete data tracking. It automates the ... through final protein expression and measurement. The ... a plate to any of its instruments ...
... extraction through columns is a well-known separation ... Typical applications are in DNA/RNA extraction in ... compound purification in chemical or analytical laboratories. ... the Genesis series instruments for smaller scales. ...
... OLIGO is a multi-functional program ... oligonucleotides from a sequence file ... DNA sequencing, site-directed mutagenesis, and ... hybridization temperature and secondary structure ...
Biology Products: