Navigation Links
MIT, BU team combats antibiotic resistance with engineered viruses
Date:3/2/2009

CAMBRIDGE, Mass.--A new approach to fighting bacterial infections, developed at MIT and Boston University, could help prevent bacteria from developing antibiotic resistance and help kill those that have already become resistant.

Researchers from both schools have engineered a virus that knocks out bacterial defense systems, enhancing the effectiveness of antibiotics. The work is reported in the March 2 online issue of the Proceedings of the National Academy of Sciences.

Antibiotic-resistant bacteria pose a serious and growing health risk. The Centers for Disease Control and Prevention estimates that the antibiotic-resistant bacterium MRSA, or methicillin-resistant Staphylococcus aureus, causes approximately 94,000 infections and contributes to 19,000 deaths annually in the United States, through contact that can occur in a variety of locations, including schools, hospitals and homes.

New drugs are needed to combat these superbugs, but very few new antibiotics have been developed in the past few decades. "There are a lot of targets to go after, but people haven't been able to find the drugs," said Timothy Lu, lead author of the paper and an MD candidate in the Harvard-MIT Division of Health Sciences and Technology (HST).

Lu and James Collins, Howard Hughes Medical Institute investigator and professor of biomedical engineering at BU, took a new approach: engineering existing bacteriophages (viruses that infect bacteria) to attack specific targets. "It's much easier to modify phages than to invent a new drug," said Lu.

Lu, who completed his PhD at HST last year, won the $30,000 Lemelson-MIT Student Prize and the grand prize in the National Collegiate Inventors Competition in 2008 for his work with engineered bacteriophages.

The engineered viruses described in the PNAS paper attack the SOS system, a bacterial DNA repair system enlisted when bacteria are exposed to antibiotics that damage DNA, and other gene networks. Used in conjunction with traditional antibiotics, the viruses undermine bacterial defense systems and prevent resistance from developing.

The researchers tested their phages with three major classes of antibiotics (quinolones, beta-lactams and aminoglyclosides) and had good results with all three. In mice infected with bacteria, those treated with both engineered bacteriophage and antibiotics had an 80 percent survival rate, compared with 50 percent for mice treated with natural bacteriophages and antibiotics, 20 percent for mice treated only with antibiotics, and 10 percent for untreated mice.

"This work lays the groundwork for the development of a library of bacteriophages, each designed to attack different bacterial targets," said Lu.

In 2007, Lu and Collins demonstrated the successful creation of an engineered virus that could attack and destroy surface "biofilms" of harmful bacteria that can form on industrial and medical devices. Such viruses could be used in food processing plants, hospitals or other settings where dangerous bacteria can accumulate.


'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Related biology technology :

1. Quick microchip test for dangerous antibiotic resistant bacteria
2. New Licence for Cubicin(R) (daptomycin), the First in a Novel Class of Antibiotic, is Announced Today for the Treatment of Serious Bloodstream and Heart Infections Caused by the Most Problematic UK Organisms, Including MRSA
3. Arpida Invited to Present Preclinical Data on Novel Topical Antibiotic AR-2474 at ICAAC
4. GlaxoSmithKline and Anacor Pharmaceuticals Form Alliance to Develop Systemic Antivirals and Antibiotics Based on Boron Chemistry
5. Drugs from Johnson & Johnson/Basilea and Forest Are the Most Promising Antibiotics in the Community-Acquired Pneumonia Pipeline
6. Rib-X Pharmaceuticals Initiates Two Phase 2 Studies for Novel Antibiotic Compound RX-1741
7. Solving the Z rings mysteries may lead to new antibiotics
8. Paratek Pharmaceuticals Completes $40 Million Private Placement to Finance Clinical Programs Including Oral Antibiotic to Combat MRSA and Other Infections
9. Skin & Aging Article Finds Derma Sciences MEDIHONEY(TM) Helps to Promote Healing Where Antibiotics Fail
10. Nektar Receives Patent Covering Pulmonary Targeted Antibiotics
11. Number of Patients Treated with an Antibiotic for MRSA Within U.S. Acute Care Hospitals Increased 8 Percent from 2006 to 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a ... eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research ... by providing practical tips, tools, and strategies for clinical researchers. , “The landscape ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)... June 23, 2016 A person commits a crime, ... scene to track the criminal down. An outbreak ... and Drug Administration (FDA) uses DNA evidence to track down ... Sound far-fetched? It,s not. The FDA has increasingly used ... investigations of foodborne illnesses. Put as simply as possible, whole ...
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
Breaking Biology Technology:
(Date:6/9/2016)... an innovation leader in attendance control systems is proud to announce the introduction of ... make sure the right employees are actually signing in, and to even control the ... ... ... ...
(Date:6/7/2016)... 7, 2016  Syngrafii Inc. and San Antonio ... that includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" ... collaboration will result in greater convenience for SACU ... while maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
Breaking Biology News(10 mins):