Navigation Links
MIT, BU team combats antibiotic resistance with engineered viruses
Date:3/2/2009

CAMBRIDGE, Mass.--A new approach to fighting bacterial infections, developed at MIT and Boston University, could help prevent bacteria from developing antibiotic resistance and help kill those that have already become resistant.

Researchers from both schools have engineered a virus that knocks out bacterial defense systems, enhancing the effectiveness of antibiotics. The work is reported in the March 2 online issue of the Proceedings of the National Academy of Sciences.

Antibiotic-resistant bacteria pose a serious and growing health risk. The Centers for Disease Control and Prevention estimates that the antibiotic-resistant bacterium MRSA, or methicillin-resistant Staphylococcus aureus, causes approximately 94,000 infections and contributes to 19,000 deaths annually in the United States, through contact that can occur in a variety of locations, including schools, hospitals and homes.

New drugs are needed to combat these superbugs, but very few new antibiotics have been developed in the past few decades. "There are a lot of targets to go after, but people haven't been able to find the drugs," said Timothy Lu, lead author of the paper and an MD candidate in the Harvard-MIT Division of Health Sciences and Technology (HST).

Lu and James Collins, Howard Hughes Medical Institute investigator and professor of biomedical engineering at BU, took a new approach: engineering existing bacteriophages (viruses that infect bacteria) to attack specific targets. "It's much easier to modify phages than to invent a new drug," said Lu.

Lu, who completed his PhD at HST last year, won the $30,000 Lemelson-MIT Student Prize and the grand prize in the National Collegiate Inventors Competition in 2008 for his work with engineered bacteriophages.

The engineered viruses described in the PNAS paper attack the SOS system, a bacterial DNA repair system enlisted when bacteria are exposed to antibiotics that damage DNA, and other ge
'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Quick microchip test for dangerous antibiotic resistant bacteria
2. New Licence for Cubicin(R) (daptomycin), the First in a Novel Class of Antibiotic, is Announced Today for the Treatment of Serious Bloodstream and Heart Infections Caused by the Most Problematic UK Organisms, Including MRSA
3. Arpida Invited to Present Preclinical Data on Novel Topical Antibiotic AR-2474 at ICAAC
4. GlaxoSmithKline and Anacor Pharmaceuticals Form Alliance to Develop Systemic Antivirals and Antibiotics Based on Boron Chemistry
5. Drugs from Johnson & Johnson/Basilea and Forest Are the Most Promising Antibiotics in the Community-Acquired Pneumonia Pipeline
6. Rib-X Pharmaceuticals Initiates Two Phase 2 Studies for Novel Antibiotic Compound RX-1741
7. Solving the Z rings mysteries may lead to new antibiotics
8. Paratek Pharmaceuticals Completes $40 Million Private Placement to Finance Clinical Programs Including Oral Antibiotic to Combat MRSA and Other Infections
9. Skin & Aging Article Finds Derma Sciences MEDIHONEY(TM) Helps to Promote Healing Where Antibiotics Fail
10. Nektar Receives Patent Covering Pulmonary Targeted Antibiotics
11. Number of Patients Treated with an Antibiotic for MRSA Within U.S. Acute Care Hospitals Increased 8 Percent from 2006 to 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
(Date:12/24/2014)... 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... clinical grade hypothermic storage and cryopreservation freeze ... cells and tissues  ("BioLife" or the "Company"), today announced that ... May 4, 2015 (the "Annual Meeting"). Because the ...
(Date:12/24/2014)... December 23, 2014 GMO corn cases filed ... are in the process of being consolidated in a Kansas ... Re: Syngenta AG MIR 162 Corn Litigation, MDL No. 2591 ... , Management of the Syngenta GMO corn multidistrict litigation (MDL) ...
(Date:12/24/2014)... SoundConnect’s 2015 next generation ... communication technology, provide continued education and inform users ... demonstrates online communication features and benefits; empowering users ... innovative and powerful tools. , According to SoundConnect’s ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... – makers of the ground-breaking hemostatic agent, WoundStat™ – today announced ... for its quality system for design, development, production and sales of ... August 2007 , ... BETHESDA, Md. (Business Wire ...
... this family reunion season, African Ancestry, Inc., offers 5 easy tips ... part of a growing trend that's changing the face of family ... ... 2008 -- By summer's end, thousands of Black families will have ...
... Therapy per Patient, Treated with an Antibiotic for MRSA Decreased ... New Data Released by ... Medical Resources,(AMR), a provider of premier market intelligence for the ... treated,with an antibiotic associated with a positive culture for MRSA ...
Cached Biology Technology: TraumaCure Receives Prestigious ISO 13485 Certification 2Families Embrace Science/Technology-based Ancestry Tracing Marking Milestone in Black Family Reunion Celebrations Across the Nation 2Families Embrace Science/Technology-based Ancestry Tracing Marking Milestone in Black Family Reunion Celebrations Across the Nation 3Number of Patients Treated with an Antibiotic for MRSA Within U.S. Acute Care Hospitals Increased 8 Percent from 2006 to 2007 2
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  Since its launch in ... of people to eliminate the pain of trying to remember ... their own biometrics fused to their smartphones. To assist people ... Labs , the company that created 1U and focuses on ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ... Monitor: North America Perimeter Security Systems Market" report to ... The North American perimeter security market is estimated to ... Although the U.S. market holds a larger share in this ...
(Date:12/17/2014)... SM announced today its completion of a Good ... current U.S. Food and Drug Administration (FDA) regulations. This ... smart phone application trials utilizing the highest principles for ... determined to improve global healthcare access, quality, and delivery ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... of externally-shelled cephalopods that thrived in the tropical ... intervening years their modern soft bodied relatives dumped ... which makes Nautilus ideally suited to discover the ... the complex coleoid [soft bodied cephalopod] brains say ...
... Airplanes, submarines and even automobiles of tomorrow ... gyroscopes for navigation and other purposes. The proprietary system ... consisting of Panos Datskos, Slo Rajic and Nickolay Lavrik ... today,s gyroscopes, which are big and costly. Instead, this ...
... with highly developed emotional sensibilities are better at making ... Journal of Consumer Research. "Consumers who understand their ... as health decisions and product choices," explain the authors, ... (University of Kentucky). "A person can know a lot ...
Cached Biology News:Story tips from the Department of Energy's Oak Ridge National Laboratory, June 2008 2Story tips from the Department of Energy's Oak Ridge National Laboratory, June 2008 3
... and 96 well plates. microCLEAN is an extremely ... half spin DNA cleanup reagent. It can be ... of double stranded DNA, efficiently removing reaction buffers, ... unlabelled). It is therefore ideally suited to clean ...
PTC-100 cycler with gold/silver block with Hot Bonnet heated lid, holds one 96-well V-plate or96x0.2ml tubes...
... Versatile stain for staining RNA (bluish-purple), DNA (blue), proteins ... TLC ≥ 90 % Cation traces: Ca ≤ 10 ... Cr ≤ 5 mg/kg Cu ≤ 5 mg/kg Fe ... 5 mg/kg Mn ≤ 5 mg/kg Na ≤ 50 ...
... The DTX Series Multimode Detectors provide ... variety of application and automation needs. ... absorbance measurements on the same instrument, ... standalone instruments or can be integrated ...
Biology Products: