Navigation Links
MIABE standard opens up new opportunities in drug discovery
Date:9/1/2011

AUDIO: This audio file is a brief interview with MIABE coauthors Sandra Orchard, John Overington, Dominic Clark and Christoph Steinbeck of the EMBL-European Bioinformatics Institute. They briefly discuss the potential impact...

Click here for more information.

An international consortium of pharmaceutical companies, public and commercial data providers and academic groups has agreed on a new standard for describing the effect of a compound on a biological entity. Published in Nature Reviews Drug Discovery, the Minimum Information about a Bioactive Entity (MIABE) standard makes it possible to enhance the interchange of public data on drug discovery success and attrition.

Every day, pharma, biotech and academic groups generate enormous quantities of data about the biological properties of molecules such as drugs, pesticides and food additives. However, not all useful data are reported. This can lead to fruitless repetition of work, wasting time, energy and resources.

A deeper understanding of what makes successful drugs work can be gained by putting together data from a large number of drug discovery programmes. But to analyse these data properly, they need to be comparable. At present, crucial data are often missing from the published literature or are reported in an unstructured format.

MIABE reporting guidelines will allow the scientific community to capture more information about bioactive compounds, and to use that information for better design.

"We hope that MIABE will make possible an order-of-magnitude increase in the amount of data available for analysis," explained Dr John Overington, who heads the ChEMBL group at the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI). "Experience with other standards has shown that as more groups come to adopt them, the amount of useable data available to researchers snowballs."

"The increased availability of standards-compliant data will help companies to streamline their decision-making processes," said Dr Dominic Clark, who coordinates the Industry Programme at EMBL-EBI. "Industry is becoming increasingly reliant on data in the public domain. Having a set of principles and standards will make data integration simpler and help to control costs."

"This new standard will bring us a wealth of well curated data about the biological targets of bioactive molecules a very timely initiative for the EMBL-EBI's current expansion in the area of metabolism and metabolomics," added Dr Christoph Steinbeck, who heads the cheminformatics team at EMBL-EBI.

MIABE is the result of a precompetitive project that originated in the EMBL-EBI Industry Programme. The ideas were originally developed in a series of drug-discovery research workshops, and the outcome will benefit industrial and academic communities alike.


'/>"/>

Contact: Mary Bergman
mary@ebi.ac.uk
44-122-349-4665
European Molecular Biology Laboratory
Source:Eurekalert

Related biology technology :

1. Randomized Study Comparing Cell Therapeutics OPAXIO (Paclitaxel Poliglumex) and Radiotherapy to Standard of Care Temozolomide and Radiotherapy Treatment Open for Enrollment
2. International Isotopes Inc. Announces Successful International Standards Certification for Manufacture of Its Nuclear Medicine Products and Devices
3. SGS Certified for ISTA Standard 20 Insulated Shipping Container Testing
4. Transgenomic Announces Discovery of a Novel Technique Which Enhances Analytic Sensitivity of Standard Sanger Sequencing to 1%
5. RadQual, LLC Announces a New Industry Leading Dose Calibrator Reference Standard
6. Dynamic Ventures Corporations Information To Be Available Through Standard & Poors Market Access Program
7. IGEN Networks Corp. obtains Blue Sky Statutory Compliance in 38 States with Approval of Standard & Poors
8. CRAiLAR® Organic Fibers is Approved for Global Organic Textile Standard Chemical Input Certification
9. OriGene Technologies Launches Over 5,000 Heavy Isotope Labeled Full-Length Human Proteins as Quantitative Internal Standards for SRM/MRM Mass Spectrometry
10. US Oncology Continues to Set the Standard as a VAWD(CM) Accredited Wholesale Distributor
11. InterTech Service to Counter Widely Reported Problems in Automotive, Medical Device and Other Industries Requiring Rigorous Quality Standards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... Research and Markets has announced the addition of the ... The global biomarkers market has ... The market is expected to grow at a five-year compound annual ... $50.6 billion in 2015 to $96.6 billion in 2020. ... to 2020) are discussed. As well, new products approved in 2013 ...
(Date:6/22/2016)... 2016   StockNewsNow.com , The Official MicroCap News ... Nader Pourhassan , President & CEO of CytoDyn ... clinical development and potential commercialization of humanized monoclonal antibodies ... to the company,s website (see here: www.CytoDyn.com ). ... th , 2016, at the LD Micro Invitational in ...
(Date:6/22/2016)... --  ViaCyte, Inc. , a privately-held regenerative medicine company ... for the treatment of diabetes in clinical-stage development, today ... 2016, the Global Stem Cell Event, is taking place ... Francisco.    ... Focus Session: Tools for Basic and Applied Stem Cell ...
(Date:6/22/2016)... ... June 22, 2016 , ... ... spotlight on immigrant achievements and contributions to North Texas and the nation, recently ... from the immigrant community to the civic and economic vitality of North Texas. ...
Breaking Biology Technology:
(Date:6/3/2016)... , June 3, 2016 ... Management) von Nepal ... und Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, ... führend in der Produktion und Implementierung von ... der Ausschreibung im Januar teilgenommen, aber Decatur ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
Breaking Biology News(10 mins):