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MDA's Augie's Quest Expands Testing of Potential ALS Therapeutics With New $2 Million Grant to ALS TDI
Date:3/1/2011

been used as the basis for two separate international standards of practice guidelines.  In addition, the partnership has funded the acquisition of nearly a million dollars of capital equipment at the Institute, which has been used to complete major gene expression studies aimed at discovering new molecular pathways related to disease onset and progression.  In addition to funding portions of those efforts at ALS TDI, the MDA grants have also directly supported the Institute's robust preclinical therapeutic screening program.  The Institute is advancing one of these potential therapies, ALS TDI 00846, toward the clinic for evaluation in people living with the disease today.  

"Our relationship with ALS TDI is producing tangible results for the worldwide ALS community.  This fast-track effort is altering the way researchers advance potential treatments for ALS and has helped many labs evaluate candidate therapeutics quicker and more efficiently than before, " said R. Rodney Howell, M.D., Chairman of the MDA Board of Directors.

This new grant from MDA's Augie's Quest will fund several projects at ALS TDI, including the screening of at least three potential therapeutics targeting novel pathways identified by the Institute.  In addition, a portion of the funding received from MDA's Augie's Quest will fund the Institute's efforts to characterize TDP-43 mouse model, an emerging model of neurodegeneration that has been related to ALS and other neurodegenerative diseases. Portions of other technology development projects around gene therapy and RNAi are also funded under the terms of the renewed grant from MDA's Augie's Quest.

"It is humbling to have the MDA continue its support of ALS TDI at such an enormous level.  It is a testament to the efficiency and innovativeness of the multi-disciplinary team working at the Institute today.  This grant will provide crucial new resources that we desperately need t
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SOURCE ALS Therapy Development Foundation
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