Navigation Links
MDA Supports Development of 'Dissociative Glucocorticoid' for DMD
Date:5/3/2012

TUCSON, Ariz., May 3, 2012 /PRNewswire-USNewswire/ -- The Muscular Dystrophy Association announced today that it has awarded $1,549,725 to ReveraGen BioPharma, a Rockville, Md., biotechnology company, to develop and test a "dissociative glucocorticoid" as a potential treatment for Duchenne muscular dystrophy (DMD).

(Logo: http://photos.prnewswire.com/prnh/20120424/DC93207LOGO)

MDA has partnered with the U.S. National Institutes of Health Therapeutics for Rare and Neglected Diseases (TRND) program in supporting development of this drug. The award was made through MDA Venture Philanthropy (MVP), the drug development arm of MDA's translational research program.

Glucocorticoid (also known as "corticosteroid") medications — such as prednisone and prednisolone — are widely prescribed in DMD, where they slow the progression of the disease, probably by reducing muscle inflammation, as well as other effects. However, glucocorticoids have many side effects, such as weight gain, reduced bone density, hypertension and psychological distress, which limit their usefulness and highlight the need for alternative therapies.

The side effects are believed to be caused mostly by the so-called "genomic" actions of glucocorticoids, while most of their benefits appear to be due to their nongenomic actions.

ReveraGen (formerly known as Validus BioPharma) says its experimental compound VB15 is designed to eliminate the genomic effects of glucocorticoids while retaining their nongenomic effects.

"We're really excited about this project," said Jane Larkindale, MDA's director of translational research. "A medication that provides the benefits of glucocorticoids without the side effects would be most welcome by the Duchenne dystrophy community. S
'/>"/>

SOURCE Muscular Dystrophy Association
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach
2. Elsevier Supports International Crisis Aid Through Pillars of Hope Campaign
3. CTRI Confirms Leading Indian CRO Supports Majority of Hemophilia Trials in India
4. The SimPL Learning Management System Supports Compliance in Healthcare Facilities
5. Adeona Announces Positive Alzheimers Subgroup Analysis that Supports Additional Clinical Study of Proprietary Zinc-Based Therapy
6. Roche Diabetes Care Forms Human Blue Circle, Supports Viral Video for World Diabetes Day
7. LCS Constructors, Inc. Supports the Cure and Breast Cancer Awareness Month
8. Powe Award supports development of nanocomposites to monitor wind turbine blade structure
9. Maryland Biotechnology Center Supports $270,000 in MIPS Projects
10. Web-Based Management Suite Supports Complex Research Consortia
11. Research in Autism Encyclopedia Shows No Link to Children With Autism, Supports Lancet Retraction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... BlueInGreen® , a water ... for delivering dissolved gases into liquids, announced the ... a manufacturer’s representative firm to its sales network. ... municipal water and wastewater applications in the Canadian ... founded in 1992 and serves Quebec and Ontario ...
(Date:9/16/2014)... 16, 2014 Cardioxyl Pharmaceuticals, Inc. ... been shown to be effective in animal models following ... to intravenous infusions that could pave the way for ... presented yesterday at the Heart Failure Society of America,s ... Las Vegas . The research, ...
(Date:9/16/2014)... -- Donald Fresne, President and CEO of Egenix, Inc. is pleased ... to its Scientific Advisory Committee. Dr. Vagner, a ... , performed research at Embl (European Molecular Biology Laboratory) Heidelberg, ... institute of health and medical research. He is a Research ... Orsay, France , and at the Gustave ...
(Date:9/16/2014)... CIRTEC Medical Systems’ Board of Directors has ... CIRTEC. , “I am delighted to be joining ... Brian Highley. “The company has made great strides improving ... over the past two years. The goal now is ... expand the services Cirtec offers its medical device customers.” ...
Breaking Biology Technology:BlueInGreen® Expands into Canada – Signs Representative Agreement with H2Flow Equipment Inc. 2Cardioxyl Presents Oral Heart Failure Treatment Data For Its Experimental HNO Prodrug At HFSA 18th Annual Scientific Meeting 2New Appointment to the Scientific Advisory Committee at Egenix, Inc. 2
... , Key ... • receptor binding assay • LEADseeker • ... The α 2 -adrenergic receptors are G protein-coupled receptors ... as renal Na + re-absorption, insulin secretion, platelet aggregation, and neurotransmitter release ...
... Key words: NK2 • GPCR ... SPA Imaging Beads , ... a family of small neuropeptides. Members of this family include peptides, substance ... hemokinin-1 (1). Neurokinins are widely distributed throughout the central and peripheral nervous ...
... Key words: formalin-fixed ... degenerate oligonucleotideprimed PCR (DOP-PCR),• Cy3/Cy5-dCTP probe labeling • comparative,genomic ... array CGH , ... Human genomic DNA isolated from formalin-fixed paraffin-embedded (FFPE) tissue ...
Cached Biology Technology:Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System 2Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System 3Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System 4Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 2Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 3Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 4GenomiPhi amplification of FFPE tissue DNA for array CGH 2GenomiPhi amplification of FFPE tissue DNA for array CGH 3GenomiPhi amplification of FFPE tissue DNA for array CGH 4GenomiPhi amplification of FFPE tissue DNA for array CGH 5GenomiPhi amplification of FFPE tissue DNA for array CGH 6GenomiPhi amplification of FFPE tissue DNA for array CGH 7GenomiPhi amplification of FFPE tissue DNA for array CGH 8GenomiPhi amplification of FFPE tissue DNA for array CGH 9GenomiPhi amplification of FFPE tissue DNA for array CGH 10
(Date:9/16/2014)... fall marks a new school year, a new football ... Space Station. In September, SpaceX,s Dragon spacecraft is scheduled ... and investigations as part of the company,s fourth contracted ... will be the third suite of research investigations sponsored ... Space (CASIS). With the role of managing the U.S. ...
(Date:9/16/2014)... of interaction between viruses, bacteria, and their environment ... international collaboration between Matthew Sullivan, associate professor in ... Evolutionary Biology and Steven Hallam from the University ... "Bacteria are drivers of nutrient and energy cycles ... climate is changing, so are the environments these ...
(Date:9/16/2014)... pipeline (KXL) would likely increase oil sands extraction, according ... the non-profit organization Near Zero. The results are detailed ... includes both supporters and opponents of the pipeline. ... lead to significantly higher greenhouse gas emissions, with the ... , "This report examines three main scenarios discussed by ...
Breaking Biology News(10 mins):CASIS research set for launch aboard SpaceX mission to space station 2CASIS research set for launch aboard SpaceX mission to space station 3New research decodes virus-host interactions in ocean dead zones 2New research decodes virus-host interactions in ocean dead zones 3Keystone XL would likely raise oil sands production and greenhouse gas emissions 2
... are often seen laughing and smiling, but this cheerful ... and seizures. , ,ew research in mice, ... alleviated. , Edwin Weeber, Ph.D., and colleagues reversed ... syndrome by preventing the inhibition of CaMKII, an enzyme ...
... sea levels in the centuries to come? Are we destroying ... oceans on the rise? Can aquaculture be environmentally sustainable? And ... coastal fisheries? , Most importantly, what can governments, industry and ... media are invited to join leading international researchers and government ...
... winner of the 2006 David Horrobin Prize for medical ... Assumption and No Two Alike, the article, "Parental selection: ... hairlessness and skin color" was judged to best embody ... in 2004, is awarded annually and named in honour ...
Cached Biology News:Angelman syndrome deficits rescued in mice 2Angelman syndrome deficits rescued in mice 3Are we killing the world's oceans? 2Why aren't humans furry? Stone-Age moms could be the answer 2
Mouse monoclonal antibody raised against a partial recombinant TTC3. NCBI Entrez Gene ID = TTC3...
Mouse polyclonal antibody raised against a partial recombinant SYT4. NCBI Entrez Gene ID = 6860...
Mouse monoclonal antibody raised against a partial recombinant IL31RA. NCBI Entrez Gene ID = IL31RA...
...
Biology Products: