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MD Biosciences Publishes the Characterization of a Porcine Model of Post-operative Or Incisional Pain in the European Journal of Pain
Date:9/25/2013

St Paul, MN (PRWEB) September 25, 2013

MD Biosciences article "Characterization of a porcine model of post-operative pain" is published in the September 2013 issue of European Journal of Pain. Dr Sigal Meilin, lead neuroscientist and research director at MD Biosciences along with colleagues developed and published a large in vivo model of post-operative pain (POP) that provides greater translational relevance for the evaluation of local treatments of POP compared with existing rodent models of incisional pain.

The management of acute pain related to surgical intervention, termed post-operative pain, continues to be a major healthcare challenge. Historically the rodent has been the model of choice for developing new analgesic treatments in the study of POP. One of the major disadvantages of the rodent model is its limited use in assessing topical and localized treatments. The anatomy of the rodent skin is also significantly different from human skin and healing occurs primarily by wound contraction rather than re-epithelialization. Porcine skin on the other hand has a higher degree of homology to human skin and heals by epidermal cell migration. There is also a considerable correlation between contracile, metabolic and morphological features in skeletal muscle of humans and pigs. The pigskin is also tightly attached to the muscle and subcutaneous tissue as in humans.

We have developed a model of post-operative pain utilizing full-skin incision or full skin and muscle incision and retraction (SIMR). We pro
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