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Lupus Research Institute Awards $3.6 Million for Novel Studies Driving Wide-Ranging New Science in Lupus
Date:2/15/2012

onal Academy of Sciences member. "Always challenging scientists to push against the boundaries allows the Institute to achieve consistent breakthrough results."

Laying Groundwork for Better B-cell Targeted Therapies

LRI investigators will explore new theories on why B cells start producing autoantibodies against the body's own cells and tissues and how this could be prevented. They will also ask which type of B cell, of the many types in our immune system, produces harmful autoantibodies and whether this varies from individual to individual – insight that will aid in designing future B cell-targeted therapies and individualized treatment.

  • Dr. Eline Luning Prak, University of Pennsylvania: "We are using cutting-edge DNA- sequencing technology to identify specific B cells that may cause lupus in individual patients.  Different B-cell-targeted lupus therapies such as Benlysta® (belimumab), aim to control the disease by clearing different disease-causing B cells from the immune system. But currently physicians do not know which types of B cells should be eliminated. We hope that our study will take the guesswork out of matching B-cell treatments to patients, improving individualized therapy."
  • Dr. Alexander Tarakhovsky, Rockefeller University: "My team's exploring an entirely novel therapeutic strategy aiming to reverse autoimmunity by targeting proteins that switch on 'bad' genes in lupus B cells through a process called epigenetics."
  • Dr. Thomas L. Rothstein, The Feinstein Institute for Medical Research: "We're studying whether B1 cells, a small B cell population whose identity in humans we recently described, produce harmful autoantibodies in lupus. If so, therapies could be developed targeting B1 cells without damaging healthy B cells that protect against infection."
  • Dr. William Kovacs<
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SOURCE Lupus Research Institute
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2. Human Genome Sciences Reports Positive Long-Term Data for BENLYSTA(TM) (Formerly LymphoStat-B(R)) in Patients With Active Systemic Lupus Erythematosus
3. Human Genome Sciences to Host July 20 Conference Call to Discuss Top-Line Phase 3 Results for Benlysta(TM) (Formerly Lymphostat-B(R)) in Systemic Lupus Erythematosus
4. Biologic Agents Will Drive the Systemic Lupus Erythematosus Drug Market to More Than Quadruple to Nearly $2 Billion in 2018
5. Promise of a New Lupus Treatment Is a Groundbreaking Achievement
6. Lupus Research Institute: Benlysta(TM) Trial Results in an Historic Research Breakthrough and Victory for People With Lupus
7. deCODE Announces Agreement With Pfizer to Search for Variants in the Human Genome That Confer Risk of Systemic Lupus Erythematosis
8. Systemic Lupus Erythematosus Therapeutics (SLE) - Pipeline Assessment and Market Forecasts to 2018
9. Human Genome Sciences Europe Moves to the Cloud With Veeva CRM to Support New Lupus Treatment
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