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Lotus Pharmaceuticals Announces New Patent for Controlled-Release Diabetes Drug
Date:10/19/2010

BEIJING, Oct. 19 /PRNewswire-Asia-FirstCall/ -- Lotus Pharmaceuticals, Inc. (OTC Bulletin Board: LTUS) ("Lotus" or the "Company"), a fast-growing, profitable developer, manufacturer and seller of medicine and drugs in the People's Republic of China ("PRC"), announced today that its wholly owned subsidiary, En Ze Jia Shi Pharmaceuticals, has been issued a patent by the State Intellectual Property Office of the People's Republic of China for controlled-release oral gliclazide. The patent covers the composition and preparation methods for the drug through 2030.

Gliclazide is commonly used to control mild to moderate adult-onset Type 2 diabetes. The drug belongs to the second generation of sulfonylureas, a class of anti-diabetic drugs that stimulate the pancreas to release more insulin. Lotus' novel controlled-release gliclazide tablet is formulated using osmotic pump technology, which encases the drug in a semi-permeable framework for a gradual, sustained release. The drug release is designed to be minimally affected by pH, gastric acid and food intake. In preclinical studies, the tablets demonstrated a similar rate of drug release in both in vitro and in vivo models.According to the Company's proprietary market research, the worldwide diabetic population is expected to reach 239 million people by 2010. China currently has about 40 million diabetic patients, with an additional 1.5 to 2 million patients diagnosed each year. China's diabetes drug market is estimated at RMB 7 billion (US $1.1 billion) annually and is expected to surpass RMB 10 billion (US $1.5 billion) in four years. Gliclazide accounts for approximately 28%, or RMB 1.25 billion (US $188.1 million), of the sulfonylurea market in China.

Chairman and Chief Executive Officer Mr. Zhongyi Liu stated, "We believe our controlled-release gliclazide tablet will have a meaningful impact on the clinical treatment
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SOURCE Lotus Pharmaceuticals, Inc.
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