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Lorus Therapeutics Provides an Update on Progress in Virulizin(R) Development Program
Date:7/9/2008

ates, to protect the use of IL-17E in the treatment of these cancers, both alone and in combination with other chemotherapies.

Virulizin(R) stimulates production of the antitumor protein TNFalpha

The article titled "Virulizin(R), a novel immunotherapy agent, stimulates TNFalpha expression in monocytes/macrophages in vitro and in vivo." was published in the journal International Immunopharmacology (volume 7, issue 10, pages 1350-9).

The study revealed that treatment with Virulizin(R) resulted in a significant induction of the cytokine TNFalpha in tumors in a mouse model of malignant melanoma. Virulizin(R) also stimulated production of TNFalpha in human macrophages in vitro. Importantly, a direct relationship between TNFalpha production by Virulizin(R) and cytotoxic activity towards cancer cells was demonstrated.

TNFalpha is a protein that is produced by cells of the immune system, particularly macrophages, which then activate other immune cells to attack tumor cells. The anticancer properties of TNFalpha are well known, and have been studied in both preclinical and clinical settings. These new findings confirm initial studies indicating that TNFalpha can contribute to the antitumor mechanism of Virulizin(R).

About Virulizin(R)

Virulizin(R) is a novel biological response modifier (or immunotherapeutic agent) that stimulates a patient's immune system through several mechanisms, including the activation of macrophages and the infiltration of natural killer cells into tumors. In preclinical studies, Virulizin(R) has demonstrated potential high levels of antitumor activity against a number of cancer indications including pancreatic cancer. Virulizin(R) has been granted orphan drug status and fast track status from the United States FDA and orphan designation from the Marketing Authorization Application with the European Medical Evaluation Agency (EMEA). A drug that receives fast track designation must demonstrate that it is intend
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